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178 related items for PubMed ID: 27180285

  • 1. Simvastatin inhibits protein isoprenylation in the brain.
    Ostrowski SM, Johnson K, Siefert M, Shank S, Sironi L, Wolozin B, Landreth GE, Ziady AG.
    Neuroscience; 2016 Aug 04; 329():264-74. PubMed ID: 27180285
    [Abstract] [Full Text] [Related]

  • 2. Statins reduce amyloid-beta production through inhibition of protein isoprenylation.
    Ostrowski SM, Wilkinson BL, Golde TE, Landreth G.
    J Biol Chem; 2007 Sep 14; 282(37):26832-26844. PubMed ID: 17646164
    [Abstract] [Full Text] [Related]

  • 3. Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.
    Zhu Y, Casey PJ, Kumar AP, Pervaiz S.
    Cell Death Dis; 2013 Apr 04; 4(4):e568. PubMed ID: 23559002
    [Abstract] [Full Text] [Related]

  • 4. Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin.
    Takeda N, Kondo M, Ito S, Ito Y, Shimokata K, Kume H.
    Am J Respir Cell Mol Biol; 2006 Dec 04; 35(6):722-9. PubMed ID: 16858009
    [Abstract] [Full Text] [Related]

  • 5. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy.
    Danesh FR, Sadeghi MM, Amro N, Philips C, Zeng L, Lin S, Sahai A, Kanwar YS.
    Proc Natl Acad Sci U S A; 2002 Jun 11; 99(12):8301-5. PubMed ID: 12048257
    [Abstract] [Full Text] [Related]

  • 6. Monitoring the cellular effects of HMG-CoA reductase inhibitors in vitro and ex vivo.
    Cicha I, Schneiderhan-Marra N, Yilmaz A, Garlichs CD, Goppelt-Struebe M.
    Arterioscler Thromb Vasc Biol; 2004 Nov 11; 24(11):2046-50. PubMed ID: 15388523
    [Abstract] [Full Text] [Related]

  • 7. Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation.
    Lee MH, Cho YS, Han YM.
    Stem Cells; 2007 Jul 11; 25(7):1654-63. PubMed ID: 17464088
    [Abstract] [Full Text] [Related]

  • 8. Impact of HMG CoA reductase inhibition on small GTPases in the heart.
    Laufs U, Kilter H, Konkol C, Wassmann S, Böhm M, Nickenig G.
    Cardiovasc Res; 2002 Mar 11; 53(4):911-20. PubMed ID: 11922901
    [Abstract] [Full Text] [Related]

  • 9. Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA.
    Tang D, Park HJ, Georgescu SP, Sebti SM, Hamilton AD, Galper JB.
    Life Sci; 2006 Sep 05; 79(15):1484-92. PubMed ID: 16740276
    [Abstract] [Full Text] [Related]

  • 10. Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases.
    Ghittoni R, Patrussi L, Pirozzi K, Pellegrini M, Lazzerini PE, Capecchi PL, Pasini FL, Baldari CT.
    FASEB J; 2005 Apr 05; 19(6):605-7. PubMed ID: 15677697
    [Abstract] [Full Text] [Related]

  • 11. Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells.
    Rombouts K, Kisanga E, Hellemans K, Wielant A, Schuppan D, Geerts A.
    J Hepatol; 2003 May 05; 38(5):564-72. PubMed ID: 12713866
    [Abstract] [Full Text] [Related]

  • 12. 3-Hydroxymethyl coenzyme A reductase inhibition attenuates spontaneous smooth muscle tone via RhoA/ROCK pathway regulated by RhoA prenylation.
    Rattan S.
    Am J Physiol Gastrointest Liver Physiol; 2010 Jun 05; 298(6):G962-9. PubMed ID: 20378830
    [Abstract] [Full Text] [Related]

  • 13. A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms.
    Nakagami H, Jensen KS, Liao JK.
    Ann Med; 2003 Jun 05; 35(6):398-403. PubMed ID: 14572163
    [Abstract] [Full Text] [Related]

  • 14. Simvastatin enhances chemotherapy in cervical cancer via inhibition of multiple prenylation-dependent GTPases-regulated pathways.
    Pan Q, Xu J, Ma L.
    Fundam Clin Pharmacol; 2020 Feb 05; 34(1):32-40. PubMed ID: 31058344
    [Abstract] [Full Text] [Related]

  • 15. Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway.
    Stamatakis K, Cernuda-Morollón E, Hernández-Perera O, Pérez-Sala D.
    J Biol Chem; 2002 Dec 20; 277(51):49389-96. PubMed ID: 12384510
    [Abstract] [Full Text] [Related]

  • 16. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors up-regulate transforming growth factor-beta signaling in cultured heart cells via inhibition of geranylgeranylation of RhoA GTPase.
    Park HJ, Galper JB.
    Proc Natl Acad Sci U S A; 1999 Sep 28; 96(20):11525-30. PubMed ID: 10500210
    [Abstract] [Full Text] [Related]

  • 17. HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation.
    Zeng L, Xu H, Chew TL, Eng E, Sadeghi MM, Adler S, Kanwar YS, Danesh FR.
    FASEB J; 2005 Nov 28; 19(13):1845-7. PubMed ID: 16160062
    [Abstract] [Full Text] [Related]

  • 18. Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery.
    Shiga N, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H.
    Circ Res; 2005 May 13; 96(9):1014-21. PubMed ID: 15817883
    [Abstract] [Full Text] [Related]

  • 19. Differential effects of simvastatin on mesangial cells.
    Heusinger-Ribeiro J, Fischer B, Goppelt-Struebe M.
    Kidney Int; 2004 Jul 13; 66(1):187-95. PubMed ID: 15200425
    [Abstract] [Full Text] [Related]

  • 20. Statins improve NASH via inhibition of RhoA and Ras.
    Schierwagen R, Maybüchen L, Hittatiya K, Klein S, Uschner FE, Braga TT, Franklin BS, Nickenig G, Strassburg CP, Plat J, Sauerbruch T, Latz E, Lütjohann D, Zimmer S, Trebicka J.
    Am J Physiol Gastrointest Liver Physiol; 2016 Oct 01; 311(4):G724-G733. PubMed ID: 27634010
    [Abstract] [Full Text] [Related]

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