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Journal Abstract Search

153 related items for PubMed ID: 27207509

  • 1. Insulin-Dependent Regulation of mTORC2-Akt-FoxO Suppresses TLR4 Signaling in Human Leukocytes: Relevance to Type 2 Diabetes.
    Zhang Z, Amorosa LF, Coyle SM, Macor MA, Birnbaum MJ, Lee LY, Haimovich B.
    Diabetes; 2016 Aug; 65(8):2224-34. PubMed ID: 27207509
    [Abstract] [Full Text] [Related]

  • 2. Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes.
    Zhang Z, Amorosa LF, Coyle SM, Macor MA, Lubitz SE, Carson JL, Birnbaum MJ, Lee LY, Haimovich B.
    J Immunol; 2015 Sep 01; 195(5):2452-60. PubMed ID: 26232429
    [Abstract] [Full Text] [Related]

  • 3. TLR4 counteracts BVRA signaling in human leukocytes via differential regulation of AMPK, mTORC1 and mTORC2.
    Zhang Z, Amorosa LF, Petrova A, Coyle S, Macor M, Nair M, Lee LY, Haimovich B.
    Sci Rep; 2019 May 07; 9(1):7020. PubMed ID: 31065010
    [Abstract] [Full Text] [Related]

  • 4. Glutamate alleviates muscle protein loss by modulating TLR4, NODs, Akt/FOXO and mTOR signaling pathways in LPS-challenged piglets.
    Kang P, Wang X, Wu H, Zhu H, Hou Y, Wang L, Liu Y.
    PLoS One; 2017 May 07; 12(8):e0182246. PubMed ID: 28783736
    [Abstract] [Full Text] [Related]

  • 5. Asparagine reduces the mRNA expression of muscle atrophy markers via regulating protein kinase B (Akt), AMP-activated protein kinase α, toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling in weaning piglets after lipopolysaccharide challenge.
    Wang X, Liu Y, Wang S, Pi D, Leng W, Zhu H, Zhang J, Shi H, Li S, Lin X, Odle J.
    Br J Nutr; 2016 Oct 07; 116(7):1188-1198. PubMed ID: 27572423
    [Abstract] [Full Text] [Related]

  • 6. Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.
    Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM.
    J Biol Chem; 2016 Jan 01; 291(1):198-214. PubMed ID: 26453307
    [Abstract] [Full Text] [Related]

  • 7. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
    Wang RH, Kim HS, Xiao C, Xu X, Gavrilova O, Deng CX.
    J Clin Invest; 2011 Nov 01; 121(11):4477-90. PubMed ID: 21965330
    [Abstract] [Full Text] [Related]

  • 8. BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans.
    Sajan MP, Ivey RA, Farese RV.
    Metabolism; 2015 Nov 01; 64(11):1454-65. PubMed ID: 26386696
    [Abstract] [Full Text] [Related]

  • 9. Systems-wide Experimental and Modeling Analysis of Insulin Signaling through Forkhead Box Protein O1 (FOXO1) in Human Adipocytes, Normally and in Type 2 Diabetes.
    Rajan MR, Nyman E, Kjølhede P, Cedersund G, Strålfors P.
    J Biol Chem; 2016 Jul 22; 291(30):15806-19. PubMed ID: 27226562
    [Abstract] [Full Text] [Related]

  • 10. Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
    Hagiwara A, Cornu M, Cybulski N, Polak P, Betz C, Trapani F, Terracciano L, Heim MH, Rüegg MA, Hall MN.
    Cell Metab; 2012 May 02; 15(5):725-38. PubMed ID: 22521878
    [Abstract] [Full Text] [Related]

  • 11. Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-κB pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options.
    Quesada AE, Nguyen ND, Rios A, Brown RE.
    Int J Clin Exp Pathol; 2014 May 02; 7(12):8732-9. PubMed ID: 25674239
    [Abstract] [Full Text] [Related]

  • 12. Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response.
    Chan TO, Zhang J, Tiegs BC, Blumhof B, Yan L, Keny N, Penny M, Li X, Pascal JM, Armen RS, Rodeck U, Penn RB.
    Biochem J; 2015 Oct 01; 471(1):37-51. PubMed ID: 26201515
    [Abstract] [Full Text] [Related]

  • 13. The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.
    Kowalsky AH, Namkoong S, Mettetal E, Park HW, Kazyken D, Fingar DC, Lee JH.
    J Biol Chem; 2020 Feb 14; 295(7):1769-1780. PubMed ID: 31915252
    [Abstract] [Full Text] [Related]

  • 14. Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells.
    Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX, Song LH.
    J Pineal Res; 2012 Nov 14; 53(4):325-34. PubMed ID: 22537289
    [Abstract] [Full Text] [Related]

  • 15. Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1.
    Brown J, Wang H, Suttles J, Graves DT, Martin M.
    J Biol Chem; 2011 Dec 30; 286(52):44295-305. PubMed ID: 22045807
    [Abstract] [Full Text] [Related]

  • 16. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
    Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM.
    Dev Cell; 2006 Dec 30; 11(6):859-71. PubMed ID: 17141160
    [Abstract] [Full Text] [Related]

  • 17. Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2).
    Destefano MA, Jacinto E.
    Biochem Soc Trans; 2013 Aug 30; 41(4):896-901. PubMed ID: 23863152
    [Abstract] [Full Text] [Related]

  • 18. Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression.
    Yasuda K, Takahashi M, Mori N.
    PLoS One; 2015 Aug 30; 10(11):e0142943. PubMed ID: 26600389
    [Abstract] [Full Text] [Related]

  • 19. Glycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS.
    Liu Y, Wang X, Wu H, Chen S, Zhu H, Zhang J, Hou Y, Hu CA, Zhang G.
    Am J Physiol Regul Integr Comp Physiol; 2016 Aug 01; 311(2):R365-73. PubMed ID: 27225947
    [Abstract] [Full Text] [Related]

  • 20. BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
    Yao Y, Suraokar M, Darnay BG, Hollier BG, Shaiken TE, Asano T, Chen CH, Chang BH, Lu Y, Mills GB, Sarbassov D, Mani SA, Abbruzzese JL, Reddy SA.
    Sci Signal; 2013 Jan 08; 6(257):ra2. PubMed ID: 23300339
    [Abstract] [Full Text] [Related]

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