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Journal Abstract Search

153 related items for PubMed ID: 27275946

  • 1. Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects.
    Davoren JE, Lee CW, Garnsey M, Brodney MA, Cordes J, Dlugolenski K, Edgerton JR, Harris AR, Helal CJ, Jenkinson S, Kauffman GW, Kenakin TP, Lazzaro JT, Lotarski SM, Mao Y, Nason DM, Northcott C, Nottebaum L, O'Neil SV, Pettersen B, Popiolek M, Reinhart V, Salomon-Ferrer R, Steyn SJ, Webb D, Zhang L, Grimwood S.
    J Med Chem; 2016 Jul 14; 59(13):6313-28. PubMed ID: 27275946
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  • 3. Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.
    Alt A, Pendri A, Bertekap RL, Li G, Benitex Y, Nophsker M, Rockwell KL, Burford NT, Sum CS, Chen J, Herbst JJ, Ferrante M, Hendricson A, Cvijic ME, Westphal RS, O'Connell J, Banks M, Zhang L, Gentles RG, Jenkins S, Loy J, Macor JE.
    J Pharmacol Exp Ther; 2016 Feb 14; 356(2):293-304. PubMed ID: 26582730
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  • 8. Design and optimization of selective azaindole amide M1 positive allosteric modulators.
    Davoren JE, O'Neil SV, Anderson DP, Brodney MA, Chenard L, Dlugolenski K, Edgerton JR, Green M, Garnsey M, Grimwood S, Harris AR, Kauffman GW, LaChapelle E, Lazzaro JT, Lee CW, Lotarski SM, Nason DM, Obach RS, Reinhart V, Salomon-Ferrer R, Steyn SJ, Webb D, Yan J, Zhang L.
    Bioorg Med Chem Lett; 2016 Jan 15; 26(2):650-655. PubMed ID: 26631313
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  • 9. An Approach to Discovering Novel Muscarinic M1 Receptor Positive Allosteric Modulators with Potent Cognitive Improvement and Minimized Gastrointestinal Dysfunction.
    Kurimoto E, Matsuda S, Shimizu Y, Sako Y, Mandai T, Sugimoto T, Sakamoto H, Kimura H.
    J Pharmacol Exp Ther; 2018 Jan 15; 364(1):28-37. PubMed ID: 29025977
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  • 10. M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease?
    Scarpa M, Hesse S, Bradley SJ.
    Adv Pharmacol; 2020 Jan 15; 88():277-310. PubMed ID: 32416870
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  • 14. A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity.
    Rook JM, Bertron JL, Cho HP, Garcia-Barrantes PM, Moran SP, Maksymetz JT, Nance KD, Dickerson JW, Remke DH, Chang S, Harp JM, Blobaum AL, Niswender CM, Jones CK, Stauffer SR, Conn PJ, Lindsley CW.
    ACS Chem Neurosci; 2018 Sep 19; 9(9):2274-2285. PubMed ID: 29701957
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  • 17. Discovery of N-substituted 7-azaindoline derivatives as potent, orally available M1 and M4 muscarinic acetylcholine receptors selective agonists.
    Takai K, Inoue Y, Konishi Y, Suwa A, Uruno Y, Matsuda H, Nakako T, Sakai M, Nishikawa H, Hashimoto G, Enomoto T, Kitamura A, Uematsu Y, Kiyoshi A, Sumiyoshi T.
    Bioorg Med Chem Lett; 2014 Jul 15; 24(14):3189-93. PubMed ID: 24856064
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  • 18. PF-06827443 Displays Robust Allosteric Agonist and Positive Allosteric Modulator Activity in High Receptor Reserve and Native Systems.
    Moran SP, Cho HP, Maksymetz J, Remke DH, Hanson RM, Niswender CM, Lindsley CW, Rook JM, Conn PJ.
    ACS Chem Neurosci; 2018 Sep 19; 9(9):2218-2224. PubMed ID: 29683646
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  • 19. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site.
    Jacobson MA, Kreatsoulas C, Pascarella DM, O'Brien JA, Sur C.
    Mol Pharmacol; 2010 Oct 19; 78(4):648-57. PubMed ID: 20660086
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