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Journal Abstract Search

153 related items for PubMed ID: 27275946

  • 21. Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors.
    Broad LM, Sanger HE, Mogg AJ, Colvin EM, Zwart R, Evans DA, Pasqui F, Sher E, Wishart GN, Barth VN, Felder CC, Goldsmith PJ.
    Br J Pharmacol; 2019 Jan; 176(1):110-126. PubMed ID: 30276808
    [Abstract] [Full Text] [Related]

  • 22. Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M1.
    Spearing PK, Cho HP, Luscombe VB, Blobaum AL, Boutaud O, Engers DW, Rodriguez AL, Niswender CM, Jeffrey Conn P, Lindsley CW, Bender AM.
    Bioorg Med Chem Lett; 2021 Sep 01; 47():128193. PubMed ID: 34118412
    [Abstract] [Full Text] [Related]

  • 23. Discovery of VU6007496: Challenges in the Development of an M1 Positive Allosteric Modulator Backup Candidate.
    Engers JL, Bollinger KA, Capstick RA, Long MF, Bender AM, Dickerson JW, Peng W, Presley CC, Cho HP, Rodriguez AL, Niswender CM, Moran SP, Xiang Z, Blobaum AL, Boutaud O, Rook JM, Engers DW, Conn PJ, Lindsley CW.
    ACS Chem Neurosci; 2024 Sep 18; 15(18):3421-3433. PubMed ID: 39197083
    [Abstract] [Full Text] [Related]

  • 24. Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M1 Positive Allosteric Modulators.
    Engers JL, Bender AM, Kalbfleisch JJ, Cho HP, Lingenfelter KS, Luscombe VB, Han C, Melancon BJ, Blobaum AL, Dickerson JW, Rook JM, Niswender CM, Emmitte KA, Conn PJ, Lindsley CW.
    ACS Chem Neurosci; 2019 Mar 20; 10(3):1035-1042. PubMed ID: 30086237
    [Abstract] [Full Text] [Related]

  • 25. 2' biaryl amides as novel and subtype selective M1 agonists. Part II: Further optimization and profiling.
    Budzik B, Garzya V, Shi D, Walker G, Lauchart Y, Lucas AJ, Rivero RA, Langmead CJ, Watson J, Wu Z, Forbes IT, Jin J.
    Bioorg Med Chem Lett; 2010 Jun 15; 20(12):3545-9. PubMed ID: 20483599
    [Abstract] [Full Text] [Related]

  • 26.
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  • 27. Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M1 Receptor Activation.
    Popiolek M, Nguyen DP, Reinhart V, Edgerton JR, Harms J, Lotarski SM, Steyn SJ, Davoren JE, Grimwood S.
    Biochemistry; 2016 Dec 27; 55(51):7073-7085. PubMed ID: 27958713
    [Abstract] [Full Text] [Related]

  • 28. Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.
    Han C, Chatterjee A, Noetzel MJ, Panarese JD, Smith E, Chase P, Hodder P, Niswender C, Conn PJ, Lindsley CW, Stauffer SR.
    Bioorg Med Chem Lett; 2015 Jan 15; 25(2):384-8. PubMed ID: 25435150
    [Abstract] [Full Text] [Related]

  • 29. Synthesis and biological evaluation of isoxazoline derivatives as potent M₁ muscarinic acetylcholine receptor agonists.
    Huang M, Suk DH, Cho NC, Bhattarai D, Kang SB, Kim Y, Pae AN, Rhim H, Keum G.
    Bioorg Med Chem Lett; 2015 Apr 01; 25(7):1546-51. PubMed ID: 25765911
    [Abstract] [Full Text] [Related]

  • 30. Stereoselective synthesis of oxazolidinonyl-fused piperidines of interest as selective muscarinic (M1) receptor agonists: a novel M1 allosteric modulator.
    Broadley KJ, Buffat MG, Burnell E, Davies RH, Moreau X, Snee S, Thomas EJ.
    Org Biomol Chem; 2016 Feb 14; 14(6):2057-89. PubMed ID: 26768599
    [Abstract] [Full Text] [Related]

  • 31. Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists.
    Vu HN, Kim JY, Hassan AH, Choi K, Park JH, Park KD, Lee JK, Pae AN, Choo H, Min SJ, Cho YS.
    Bioorg Med Chem Lett; 2016 Jan 01; 26(1):140-4. PubMed ID: 26598462
    [Abstract] [Full Text] [Related]

  • 32. Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration.
    Panarese JD, Cho HP, Adams JJ, Nance KD, Garcia-Barrantes PM, Chang S, Morrison RD, Blobaum AL, Niswender CM, Stauffer SR, Conn PJ, Lindsley CW.
    Bioorg Med Chem Lett; 2016 Aug 01; 26(15):3822-5. PubMed ID: 27173801
    [Abstract] [Full Text] [Related]

  • 33. Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.
    Kuduk SD, Chang RK, Di Marco CN, Pitts DR, Greshock TJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT, Ray WJ.
    J Med Chem; 2011 Jul 14; 54(13):4773-80. PubMed ID: 21682298
    [Abstract] [Full Text] [Related]

  • 34. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.
    Bridges TM, Kennedy JP, Cho HP, Breininger ML, Gentry PR, Hopkins CR, Conn PJ, Lindsley CW.
    Bioorg Med Chem Lett; 2010 Jan 15; 20(2):558-62. PubMed ID: 20004578
    [Abstract] [Full Text] [Related]

  • 35. Discovery of dihydroquinazolinone derivatives as potent, selective, and CNS-penetrant M(1) and M(4) muscarinic acetylcholine receptors agonists.
    Uruno Y, Konishi Y, Suwa A, Takai K, Tojo K, Nakako T, Sakai M, Enomoto T, Matsuda H, Kitamura A, Sumiyoshi T.
    Bioorg Med Chem Lett; 2015 Nov 15; 25(22):5357-61. PubMed ID: 26428869
    [Abstract] [Full Text] [Related]

  • 36. Muscarinic receptor 1 agonist activity of novel N-aryl carboxamide substituted 3-morpholino arecoline derivatives in Alzheimer's presenile dementia models.
    Malviya M, Kumar YC, Mythri RB, Venkateshappa C, Subhash MN, Rangappa KS.
    Bioorg Med Chem; 2009 Aug 01; 17(15):5526-34. PubMed ID: 19595599
    [Abstract] [Full Text] [Related]

  • 37. 2' biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR.
    Budzik B, Garzya V, Shi D, Foley JJ, Rivero RA, Langmead CJ, Watson J, Wu Z, Forbes IT, Jin J.
    Bioorg Med Chem Lett; 2010 Jun 15; 20(12):3540-4. PubMed ID: 20483611
    [Abstract] [Full Text] [Related]

  • 38. Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.
    Wood MR, Noetzel MJ, Tarr JC, Rodriguez AL, Lamsal A, Chang S, Foster JJ, Smith E, Chase P, Hodder PS, Engers DW, Niswender CM, Brandon NJ, Wood MW, Duggan ME, Conn PJ, Bridges TM, Lindsley CW.
    Bioorg Med Chem Lett; 2016 Sep 01; 26(17):4282-6. PubMed ID: 27476142
    [Abstract] [Full Text] [Related]

  • 39. Novel M(1) allosteric ligands: a patent review.
    Kuduk SD, Beshore DC.
    Expert Opin Ther Pat; 2012 Dec 01; 22(12):1385-98. PubMed ID: 23092292
    [Abstract] [Full Text] [Related]

  • 40. The discovery of VU0486846: steep SAR from a series of M1 PAMs based on a novel benzomorpholine core.
    Bertron JL, Cho HP, Garcia-Barrantes PM, Panarese JD, Salovich JM, Nance KD, Engers DW, Rook JM, Blobaum AL, Niswender CM, Stauffer SR, Conn PJ, Lindsley CW.
    Bioorg Med Chem Lett; 2018 Jul 01; 28(12):2175-2179. PubMed ID: 29754948
    [Abstract] [Full Text] [Related]

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