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130 related items for PubMed ID: 27313224

  • 1. Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1.
    Mahrhold S, Bergström T, Stern D, Dorner BG, Åstot C, Rummel A.
    Biochem J; 2016 Sep 01; 473(17):2645-54. PubMed ID: 27313224
    [Abstract] [Full Text] [Related]

  • 2. Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin.
    Weisemann J, Stern D, Mahrhold S, Dorner BG, Rummel A.
    Toxins (Basel); 2016 May 17; 8(5):. PubMed ID: 27196927
    [Abstract] [Full Text] [Related]

  • 3. Two Feet on the Membrane: Uptake of Clostridial Neurotoxins.
    Rummel A.
    Curr Top Microbiol Immunol; 2017 May 17; 406():1-37. PubMed ID: 27921176
    [Abstract] [Full Text] [Related]

  • 4. Structural basis of botulinum neurotoxin serotype A1 binding to human SV2A or SV2C receptors.
    Azzaz F, Hilaire D, Fantini J.
    Chem Biol Interact; 2023 Mar 01; 373():110384. PubMed ID: 36754227
    [Abstract] [Full Text] [Related]

  • 5. Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity.
    Rummel A.
    Curr Top Microbiol Immunol; 2013 Mar 01; 364():61-90. PubMed ID: 23239349
    [Abstract] [Full Text] [Related]

  • 6. Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F.
    Fu Z, Chen C, Barbieri JT, Kim JJ, Baldwin MR.
    Biochemistry; 2009 Jun 23; 48(24):5631-41. PubMed ID: 19476346
    [Abstract] [Full Text] [Related]

  • 7. Structural insights into the interaction of botulinum neurotoxin a with its neuronal receptor SV2C.
    Li X, Brunner C, Wu Y, Leka O, Schneider G, Kammerer RA.
    Toxicon; 2020 Feb 23; 175():36-43. PubMed ID: 31783045
    [Abstract] [Full Text] [Related]

  • 8. Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.
    Gustafsson R, Zhang S, Masuyer G, Dong M, Stenmark P.
    Toxins (Basel); 2018 Apr 12; 10(4):. PubMed ID: 29649119
    [Abstract] [Full Text] [Related]

  • 9. Understanding peptide competitive inhibition of botulinum neurotoxin A binding to SV2 protein via molecular dynamics simulations.
    Chang S, He HQ, Shen L, Wan H.
    Biopolymers; 2015 Oct 12; 103(10):597-608. PubMed ID: 26178648
    [Abstract] [Full Text] [Related]

  • 10. Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes.
    Baldwin MR, Barbieri JT.
    Biochemistry; 2007 Mar 20; 46(11):3200-10. PubMed ID: 17311420
    [Abstract] [Full Text] [Related]

  • 11. Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A.
    Benoit RM, Frey D, Hilbert M, Kevenaar JT, Wieser MM, Stirnimann CU, McMillan D, Ceska T, Lebon F, Jaussi R, Steinmetz MO, Schertler GF, Hoogenraad CC, Capitani G, Kammerer RA.
    Nature; 2014 Jan 02; 505(7481):108-11. PubMed ID: 24240280
    [Abstract] [Full Text] [Related]

  • 12. SV2 is the protein receptor for botulinum neurotoxin A.
    Dong M, Yeh F, Tepp WH, Dean C, Johnson EA, Janz R, Chapman ER.
    Science; 2006 Apr 28; 312(5773):592-6. PubMed ID: 16543415
    [Abstract] [Full Text] [Related]

  • 13. Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2.
    Liu Z, Lee PG, Krez N, Lam KH, Liu H, Przykopanski A, Chen P, Yao G, Zhang S, Tremblay JM, Perry K, Shoemaker CB, Rummel A, Dong M, Jin R.
    Nat Commun; 2023 Apr 24; 14(1):2338. PubMed ID: 37095076
    [Abstract] [Full Text] [Related]

  • 14. Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E.
    Mahrhold S, Strotmeier J, Garcia-Rodriguez C, Lou J, Marks JD, Rummel A, Binz T.
    Biochem J; 2013 Jul 01; 453(1):37-47. PubMed ID: 23621114
    [Abstract] [Full Text] [Related]

  • 15. The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves.
    Mahrhold S, Rummel A, Bigalke H, Davletov B, Binz T.
    FEBS Lett; 2006 Apr 03; 580(8):2011-4. PubMed ID: 16545378
    [Abstract] [Full Text] [Related]

  • 16. Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors.
    Peng L, Tepp WH, Johnson EA, Dong M.
    PLoS Pathog; 2011 Mar 03; 7(3):e1002008. PubMed ID: 21483489
    [Abstract] [Full Text] [Related]

  • 17. Botulinum Neurotoxin A4 Has a 1000-Fold Reduced Potency Due to Three Single Amino Acid Alterations in the Protein Receptor Binding Domain.
    Tepp WH, Bradshaw M, Gardner AP, Kaufman RL, Barbieri JT, Pellett S.
    Int J Mol Sci; 2023 Mar 16; 24(6):. PubMed ID: 36982762
    [Abstract] [Full Text] [Related]

  • 18. N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.
    Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R.
    Nat Struct Mol Biol; 2016 Jul 16; 23(7):656-62. PubMed ID: 27294781
    [Abstract] [Full Text] [Related]

  • 19. Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry.
    Joensuu M, Syed P, Saber SH, Lanoue V, Wallis TP, Rae J, Blum A, Gormal RS, Small C, Sanders S, Jiang A, Mahrhold S, Krez N, Cousin MA, Cooper-White R, Cooper-White JJ, Collins BM, Parton RG, Balistreri G, Rummel A, Meunier FA.
    EMBO J; 2023 Jul 03; 42(13):e112095. PubMed ID: 37226896
    [Abstract] [Full Text] [Related]

  • 20. Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor.
    Rummel A, Häfner K, Mahrhold S, Darashchonak N, Holt M, Jahn R, Beermann S, Karnath T, Bigalke H, Binz T.
    J Neurochem; 2009 Sep 03; 110(6):1942-54. PubMed ID: 19650874
    [Abstract] [Full Text] [Related]

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