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332 related items for PubMed ID: 27342779

  • 1. β2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function.
    Kim D, Pauer SH, Yong HM, An SS, Liggett SB.
    J Biol Chem; 2016 Aug 19; 291(34):17616-28. PubMed ID: 27342779
    [Abstract] [Full Text] [Related]

  • 2. Mechanism regulating proasthmatic effects of prolonged homologous beta2-adrenergic receptor desensitization in airway smooth muscle.
    Nino G, Hu A, Grunstein JS, Grunstein MM.
    Am J Physiol Lung Cell Mol Physiol; 2009 Oct 19; 297(4):L746-57. PubMed ID: 19666775
    [Abstract] [Full Text] [Related]

  • 3. A CREB-mediated increase in miRNA let-7f during prolonged β-agonist exposure: a novel mechanism of β2-adrenergic receptor down-regulation in airway smooth muscle.
    Kim D, Cho S, Woo JA, Liggett SB.
    FASEB J; 2018 Jul 19; 32(7):3680-3688. PubMed ID: 29455573
    [Abstract] [Full Text] [Related]

  • 4. Prolonged heterologous beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction.
    Hu A, Nino G, Grunstein JS, Fatma S, Grunstein MM.
    Am J Physiol Lung Cell Mol Physiol; 2008 Jun 19; 294(6):L1055-67. PubMed ID: 18359889
    [Abstract] [Full Text] [Related]

  • 5. Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signaling.
    Wang WC, Mihlbachler KA, Brunnett AC, Liggett SB.
    Proc Natl Acad Sci U S A; 2009 Sep 01; 106(35):15007-12. PubMed ID: 19706446
    [Abstract] [Full Text] [Related]

  • 6. Development and characterization of pepducins as Gs-biased allosteric agonists.
    Carr R, Du Y, Quoyer J, Panettieri RA, Janz JM, Bouvier M, Kobilka BK, Benovic JL.
    J Biol Chem; 2014 Dec 26; 289(52):35668-84. PubMed ID: 25395624
    [Abstract] [Full Text] [Related]

  • 7. The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14.
    Kim D, Castaño M, Lujan LK, Woo JA, Liggett SB.
    J Biol Chem; 2021 Dec 26; 296():100216. PubMed ID: 33465377
    [Abstract] [Full Text] [Related]

  • 8. Membrane-permeable tastants amplify β2-adrenergic receptor signaling and delay receptor desensitization via intracellular inhibition of GRK2's kinase activity.
    Malach E, Shaul ME, Peri I, Huang L, Spielman AI, Seger R, Naim M.
    Biochim Biophys Acta; 2015 Jul 26; 1850(7):1375-88. PubMed ID: 25857770
    [Abstract] [Full Text] [Related]

  • 9. Targeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle.
    Wang WC, Pauer SH, Smith DC, Dixon MA, Disimile DJ, Panebra A, An SS, Camoretti-Mercado B, Liggett SB.
    Am J Physiol Lung Cell Mol Physiol; 2014 Nov 15; 307(10):L775-80. PubMed ID: 25260754
    [Abstract] [Full Text] [Related]

  • 10. Mechanisms of acute desensitization of the beta2AR-adenylyl cyclase pathway in human airway smooth muscle.
    Penn RB, Panettieri RA, Benovic JL.
    Am J Respir Cell Mol Biol; 1998 Aug 15; 19(2):338-48. PubMed ID: 9698608
    [Abstract] [Full Text] [Related]

  • 11. Heterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes.
    Shi Q, Li M, Mika D, Fu Q, Kim S, Phan J, Shen A, Vandecasteele G, Xiang YK.
    Cardiovasc Res; 2017 May 01; 113(6):656-670. PubMed ID: 28339772
    [Abstract] [Full Text] [Related]

  • 12. Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via Gαi1,2,3.
    Kim D, Woo JA, Geffken E, An SS, Liggett SB.
    Am J Respir Cell Mol Biol; 2017 Jun 01; 56(6):762-771. PubMed ID: 28145731
    [Abstract] [Full Text] [Related]

  • 13. TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis.
    An SS, Wang WC, Koziol-White CJ, Ahn K, Lee DY, Kurten RC, Panettieri RA, Liggett SB.
    Am J Physiol Lung Cell Mol Physiol; 2012 Aug 15; 303(4):L304-11. PubMed ID: 22683571
    [Abstract] [Full Text] [Related]

  • 14. Salmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of β2-Adrenergic Receptors.
    Gimenez LE, Baameur F, Vayttaden SJ, Clark RB.
    Mol Pharmacol; 2015 Jun 15; 87(6):954-64. PubMed ID: 25784721
    [Abstract] [Full Text] [Related]

  • 15. Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies.
    Tran TM, Friedman J, Qunaibi E, Baameur F, Moore RH, Clark RB.
    Mol Pharmacol; 2004 Jan 15; 65(1):196-206. PubMed ID: 14722251
    [Abstract] [Full Text] [Related]

  • 16. β2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway.
    Galaz-Montoya M, Wright SJ, Rodriguez GJ, Lichtarge O, Wensel TG.
    J Biol Chem; 2017 Jun 16; 292(24):9967-9974. PubMed ID: 28442571
    [Abstract] [Full Text] [Related]

  • 17. Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitization of the beta2-adrenergic receptor.
    McGraw DW, Liggett SB.
    J Biol Chem; 1997 Mar 14; 272(11):7338-44. PubMed ID: 9054432
    [Abstract] [Full Text] [Related]

  • 18. Differential long-term regulation of TAS2R14 by structurally distinct agonists.
    Woo JA, Castaño M, Goss A, Kim D, Lewandowski EM, Chen Y, Liggett SB.
    FASEB J; 2019 Nov 14; 33(11):12213-12225. PubMed ID: 31430434
    [Abstract] [Full Text] [Related]

  • 19. Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors.
    Robinett KS, Deshpande DA, Malone MM, Liggett SB.
    Am J Respir Cell Mol Biol; 2011 Nov 14; 45(5):1069-74. PubMed ID: 21642585
    [Abstract] [Full Text] [Related]

  • 20. Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes.
    Fu Q, Xu B, Parikh D, Cervantes D, Xiang YK.
    Cell Signal; 2015 Mar 14; 27(3):707-15. PubMed ID: 25460042
    [Abstract] [Full Text] [Related]

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