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328 related items for PubMed ID: 27395786

  • 1. Metabotropic glutamate receptor, mGlu5, regulates hippocampal synaptic plasticity and is required for tetanisation-triggered changes in theta and gamma oscillations.
    Bikbaev A, Manahan-Vaughan D.
    Neuropharmacology; 2017 Mar 15; 115():20-29. PubMed ID: 27395786
    [Abstract] [Full Text] [Related]

  • 2. Metabotropic glutamate receptor, mGlu5, mediates enhancements of hippocampal long-term potentiation after environmental enrichment in young and old mice.
    Buschler A, Manahan-Vaughan D.
    Neuropharmacology; 2017 Mar 15; 115():42-50. PubMed ID: 27267685
    [Abstract] [Full Text] [Related]

  • 3. mGlu5 acts as a switch for opposing forms of synaptic plasticity at mossy fiber-CA3 and commissural associational-CA3 synapses.
    Hagena H, Manahan-Vaughan D.
    J Neurosci; 2015 Mar 25; 35(12):4999-5006. PubMed ID: 25810529
    [Abstract] [Full Text] [Related]

  • 4. ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities.
    Liu F, Grauer S, Kelley C, Navarra R, Graf R, Zhang G, Atkinson PJ, Popiolek M, Wantuch C, Khawaja X, Smith D, Olsen M, Kouranova E, Lai M, Pruthi F, Pulicicchio C, Day M, Gilbert A, Pausch MH, Brandon NJ, Beyer CE, Comery TA, Logue S, Rosenzweig-Lipson S, Marquis KL.
    J Pharmacol Exp Ther; 2008 Dec 25; 327(3):827-39. PubMed ID: 18753411
    [Abstract] [Full Text] [Related]

  • 5. Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation.
    Naie K, Manahan-Vaughan D.
    Cereb Cortex; 2004 Feb 25; 14(2):189-98. PubMed ID: 14704216
    [Abstract] [Full Text] [Related]

  • 6. MGluR5 mediates the interaction between late-LTP, network activity, and learning.
    Bikbaev A, Neyman S, Ngomba RT, Conn PJ, Nicoletti F, Manahan-Vaughan D.
    PLoS One; 2008 May 14; 3(5):e2155. PubMed ID: 18478073
    [Abstract] [Full Text] [Related]

  • 7. Negative versus positive allosteric modulation of metabotropic glutamate receptors (mGluR5): indices for potential pro-cognitive drug properties based on EEG network oscillations and sleep-wake organization in rats.
    Ahnaou A, Langlois X, Steckler T, Bartolome-Nebreda JM, Drinkenburg WH.
    Psychopharmacology (Berl); 2015 Mar 14; 232(6):1107-22. PubMed ID: 25323624
    [Abstract] [Full Text] [Related]

  • 8. Differential effect of the mGlu5 receptor positive allosteric modulator ADX-47273 on early and late hippocampal LTP.
    Kroker KS, Rast G, Rosenbrock H.
    Neuropharmacology; 2011 Sep 14; 61(4):707-14. PubMed ID: 21640734
    [Abstract] [Full Text] [Related]

  • 9. ADX-47273, a mGlu5 receptor positive allosteric modulator, attenuates deficits in cognitive flexibility induced by withdrawal from 'binge-like' ethanol exposure in rats.
    Marszalek-Grabska M, Gibula-Bruzda E, Bodzon-Kulakowska A, Suder P, Gawel K, Talarek S, Listos J, Kedzierska E, Danysz W, Kotlinska JH.
    Behav Brain Res; 2018 Feb 15; 338():9-16. PubMed ID: 29030082
    [Abstract] [Full Text] [Related]

  • 10. The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors.
    Bortolotto ZA, Collett VJ, Conquet F, Jia Z, van der Putten H, Collingridge GL.
    Neuropharmacology; 2005 Feb 15; 49 Suppl 1():13-25. PubMed ID: 16024054
    [Abstract] [Full Text] [Related]

  • 11. An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats.
    Manahan-Vaughan D, Ngomba RT, Storto M, Kulla A, Catania MV, Chiechio S, Rampello L, Passarelli F, Capece A, Reymann KG, Nicoletti F.
    Neuropharmacology; 2003 Jan 15; 44(1):17-25. PubMed ID: 12559118
    [Abstract] [Full Text] [Related]

  • 12. Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery.
    Sengmany K, Singh J, Stewart GD, Conn PJ, Christopoulos A, Gregory KJ.
    Neuropharmacology; 2017 Mar 15; 115():60-72. PubMed ID: 27392634
    [Abstract] [Full Text] [Related]

  • 13. Synaptic strength at the temporoammonic input to the hippocampal CA1 region in vivo is regulated by NMDA receptors, metabotropic glutamate receptors and voltage-gated calcium channels.
    Aksoy-Aksel A, Manahan-Vaughan D.
    Neuroscience; 2015 Nov 19; 309():191-9. PubMed ID: 25791230
    [Abstract] [Full Text] [Related]

  • 14. Stimulation on the positive phase of hippocampal theta rhythm induces long-term potentiation that can Be depotentiated by stimulation on the negative phase in area CA1 in vivo.
    Hölscher C, Anwyl R, Rowan MJ.
    J Neurosci; 1997 Aug 15; 17(16):6470-7. PubMed ID: 9236254
    [Abstract] [Full Text] [Related]

  • 15. Hippocampal network activity is transiently altered by induction of long-term potentiation in the dentate gyrus of freely behaving rats.
    Bikbaev A, Manahan-Vaughan D.
    Front Behav Neurosci; 2007 Aug 15; 1():7. PubMed ID: 18958189
    [Abstract] [Full Text] [Related]

  • 16. Place field stability requires the metabotropic glutamate receptor, mGlu5.
    Zhang S, Manahan-Vaughan D.
    Hippocampus; 2014 Nov 15; 24(11):1330-40. PubMed ID: 24910241
    [Abstract] [Full Text] [Related]

  • 17. Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices.
    Rammes G, Hasenjäger A, Sroka-Saidi K, Deussing JM, Parsons CG.
    Neuropharmacology; 2011 May 15; 60(6):982-90. PubMed ID: 21310164
    [Abstract] [Full Text] [Related]

  • 18. Hippocampal long-term depression is facilitated by the acquisition and updating of memory of spatial auditory content and requires mGlu5 activation.
    Dietz B, Manahan-Vaughan D.
    Neuropharmacology; 2017 Mar 15; 115():30-41. PubMed ID: 27055771
    [Abstract] [Full Text] [Related]

  • 19. Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator.
    Rosenbrock H, Kramer G, Hobson S, Koros E, Grundl M, Grauert M, Reymann KG, Schröder UH.
    Eur J Pharmacol; 2010 Aug 10; 639(1-3):40-6. PubMed ID: 20371241
    [Abstract] [Full Text] [Related]

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