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Journal Abstract Search

308 related items for PubMed ID: 27448651

  • 1. Potential for the Rational Design of Allosteric Modulators of Class C GPCRs.
    Christopher JA, Doré AS, Tehan BG.
    Curr Top Med Chem; 2017; 17(1):71-78. PubMed ID: 27448651
    [Abstract] [Full Text] [Related]

  • 2. "Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands.
    Hellyer SD, Albold S, Wang T, Chen ANY, May LT, Leach K, Gregory KJ.
    Mol Pharmacol; 2018 May; 93(5):504-514. PubMed ID: 29514854
    [Abstract] [Full Text] [Related]

  • 3. Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.
    Lindsley CW, Emmitte KA, Hopkins CR, Bridges TM, Gregory KJ, Niswender CM, Conn PJ.
    Chem Rev; 2016 Jun 08; 116(11):6707-41. PubMed ID: 26882314
    [Abstract] [Full Text] [Related]

  • 4. Small Molecule Allosteric Modulators of G-Protein-Coupled Receptors: Drug-Target Interactions.
    Lu S, Zhang J.
    J Med Chem; 2019 Jan 10; 62(1):24-45. PubMed ID: 29457894
    [Abstract] [Full Text] [Related]

  • 5. Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5.
    Bian Y, Feng Z, Yang P, Xie XQ.
    AAPS J; 2017 Jul 10; 19(4):1235-1248. PubMed ID: 28560482
    [Abstract] [Full Text] [Related]

  • 6. Recent advances in drug discovery of GPCR allosteric modulators for neurodegenerative disorders.
    Lütjens R, Rocher JP.
    Curr Opin Pharmacol; 2017 Feb 10; 32():91-95. PubMed ID: 28135635
    [Abstract] [Full Text] [Related]

  • 7. Molecular insights into allosteric modulation of Class C G protein-coupled receptors.
    Leach K, Gregory KJ.
    Pharmacol Res; 2017 Feb 10; 116():105-118. PubMed ID: 27965032
    [Abstract] [Full Text] [Related]

  • 8. [Recent advances in the structural biology of the class C G protein-coupled receptors: The metabotropic Glutamate receptor 5].
    Berto L, Dumazer A, Malhaire F, Cannone G, Kutti Ragunath V, Goudet C, Lebon G.
    Biol Aujourdhui; 2021 Feb 10; 215(3-4):85-94. PubMed ID: 35275053
    [Abstract] [Full Text] [Related]

  • 9. The role of water and protein flexibility in the structure-based virtual screening of allosteric GPCR modulators: an mGlu5 receptor case study.
    Orgován Z, Ferenczy GG, Keserű GM.
    J Comput Aided Mol Des; 2019 Sep 10; 33(9):787-797. PubMed ID: 31542869
    [Abstract] [Full Text] [Related]

  • 10. Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators.
    Bennett KA, Christopher JA, Tehan BG.
    Adv Pharmacol; 2020 Sep 10; 88():35-58. PubMed ID: 32416871
    [Abstract] [Full Text] [Related]

  • 11. The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors.
    Zhang L, Mobbs JI, May LT, Glukhova A, Thal DM.
    Curr Opin Struct Biol; 2023 Apr 10; 79():102560. PubMed ID: 36848776
    [Abstract] [Full Text] [Related]

  • 12. The use of conformationally thermostabilised GPCRs in drug discovery: application to fragment, structure and biophysical techniques.
    Tehan BG, Christopher JA.
    Curr Opin Pharmacol; 2016 Oct 10; 30():8-13. PubMed ID: 27400445
    [Abstract] [Full Text] [Related]

  • 13. Applying Structure-Based Drug Design Approaches to Allosteric Modulators of GPCRs.
    Congreve M, Oswald C, Marshall FH.
    Trends Pharmacol Sci; 2017 Sep 10; 38(9):837-847. PubMed ID: 28648526
    [Abstract] [Full Text] [Related]

  • 14. Computational Drug Design Applied to the Study of Metabotropic Glutamate Receptors.
    Llinas Del Torrent C, Pérez-Benito L, Tresadern G.
    Molecules; 2019 Mar 20; 24(6):. PubMed ID: 30897742
    [Abstract] [Full Text] [Related]

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  • 16. Photoswitchable allosteric modulators for metabotropic glutamate receptors.
    Gómez-Santacana X, Panarello S, Rovira X, Llebaria A.
    Curr Opin Pharmacol; 2022 Oct 20; 66():102266. PubMed ID: 35870289
    [Abstract] [Full Text] [Related]

  • 17. Structures of class B G protein-coupled receptors: prospects for drug discovery.
    Hausch F.
    Angew Chem Int Ed Engl; 2013 Dec 02; 52(49):12783-5. PubMed ID: 24127232
    [Abstract] [Full Text] [Related]

  • 18. Allosteric modulators of metabotropic glutamate receptors: lessons learnt from mGlu1, mGlu2 and mGlu5 potentiators and antagonists.
    Johnson MP, Nisenbaum ES, Large TH, Emkey R, Baez M, Kingston AE.
    Biochem Soc Trans; 2004 Nov 02; 32(Pt 5):881-7. PubMed ID: 15494040
    [Abstract] [Full Text] [Related]

  • 19. Allosteric modulators of G-protein-coupled receptors.
    May LT, Christopoulos A.
    Curr Opin Pharmacol; 2003 Oct 02; 3(5):551-6. PubMed ID: 14559102
    [Abstract] [Full Text] [Related]

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