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Journal Abstract Search

248 related items for PubMed ID: 27482906

  • 1. Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity.
    Pedersen NM, Thorvaldsen TE, Schultz SW, Wenzel EM, Stenmark H.
    PLoS One; 2016; 11(8):e0160507. PubMed ID: 27482906
    [Abstract] [Full Text] [Related]

  • 2. Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation.
    Thorvaldsen TE, Pedersen NM, Wenzel EM, Stenmark H.
    PLoS One; 2017; 12(1):e0170508. PubMed ID: 28107521
    [Abstract] [Full Text] [Related]

  • 3. Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes.
    Thorvaldsen TE, Pedersen NM, Wenzel EM, Schultz SW, Brech A, Liestøl K, Waaler J, Krauss S, Stenmark H.
    Mol Cancer Res; 2015 Nov; 13(11):1487-501. PubMed ID: 26124443
    [Abstract] [Full Text] [Related]

  • 4. Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta.
    Martino-Echarri E, Brocardo MG, Mills KM, Henderson BR.
    PLoS One; 2016 Nov; 11(3):e0150484. PubMed ID: 26930278
    [Abstract] [Full Text] [Related]

  • 5. Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.
    Ma L, Wang X, Jia T, Wei W, Chua MS, So S.
    Oncotarget; 2015 Sep 22; 6(28):25390-401. PubMed ID: 26246473
    [Abstract] [Full Text] [Related]

  • 6. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.
    Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S.
    Cancer Res; 2012 Jun 01; 72(11):2822-32. PubMed ID: 22440753
    [Abstract] [Full Text] [Related]

  • 7. The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2.
    Croy HE, Fuller CN, Giannotti J, Robinson P, Foley AVA, Yamulla RJ, Cosgriff S, Greaves BD, von Kleeck RA, An HH, Powers CM, Tran JK, Tocker AM, Jacob KD, Davis BK, Roberts DM.
    J Biol Chem; 2016 Jun 10; 291(24):12747-12760. PubMed ID: 27068743
    [Abstract] [Full Text] [Related]

  • 8. The Discovery and Characterization of K-756, a Novel Wnt/β-Catenin Pathway Inhibitor Targeting Tankyrase.
    Okada-Iwasaki R, Takahashi Y, Watanabe Y, Ishida H, Saito J, Nakai R, Asai A.
    Mol Cancer Ther; 2016 Jul 10; 15(7):1525-34. PubMed ID: 27196752
    [Abstract] [Full Text] [Related]

  • 9. Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.
    Callow MG, Tran H, Phu L, Lau T, Lee J, Sandoval WN, Liu PS, Bheddah S, Tao J, Lill JR, Hongo JA, Davis D, Kirkpatrick DS, Polakis P, Costa M.
    PLoS One; 2011 Jul 10; 6(7):e22595. PubMed ID: 21799911
    [Abstract] [Full Text] [Related]

  • 10. A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.
    Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M.
    Cancer Res; 2013 May 15; 73(10):3132-44. PubMed ID: 23539443
    [Abstract] [Full Text] [Related]

  • 11. APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer.
    Tanaka N, Mashima T, Mizutani A, Sato A, Aoyama A, Gong B, Yoshida H, Muramatsu Y, Nakata K, Matsuura M, Katayama R, Nagayama S, Fujita N, Sugimoto Y, Seimiya H.
    Mol Cancer Ther; 2017 Apr 15; 16(4):752-762. PubMed ID: 28179481
    [Abstract] [Full Text] [Related]

  • 12. Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.
    Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, Mohammed S, Heck AJ, Maurice MM, Mahmoudi T, Clevers H.
    Cell; 2012 Jun 08; 149(6):1245-56. PubMed ID: 22682247
    [Abstract] [Full Text] [Related]

  • 13. Evidence for tankyrases as antineoplastic targets in lung cancer.
    Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ.
    BMC Cancer; 2013 Apr 28; 13():211. PubMed ID: 23621985
    [Abstract] [Full Text] [Related]

  • 14. Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling.
    Wang Z, Tacchelly-Benites O, Yang E, Ahmed Y.
    PLoS Genet; 2016 Dec 28; 12(12):e1006494. PubMed ID: 27959917
    [Abstract] [Full Text] [Related]

  • 15. Thr160 of Axin1 is critical for the formation and function of the β-catenin destruction complex.
    Koyama-Nasu R, Hayashi T, Nasu-Nishimura Y, Akiyama T, Yamanaka R.
    Biochem Biophys Res Commun; 2015 Apr 10; 459(3):411-5. PubMed ID: 25735981
    [Abstract] [Full Text] [Related]

  • 16. Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines.
    Wang W, Liu P, Lavrijsen M, Li S, Zhang R, Li S, van de Geer WS, van de Werken HJG, Peppelenbosch MP, Smits R.
    Sci Rep; 2021 Apr 02; 11(1):7470. PubMed ID: 33811251
    [Abstract] [Full Text] [Related]

  • 17. RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
    Mizutani A, Yashiroda Y, Muramatsu Y, Yoshida H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
    Cancer Sci; 2018 Dec 02; 109(12):4003-4014. PubMed ID: 30238564
    [Abstract] [Full Text] [Related]

  • 18. The Anti-Tumor Activity of Succinyl Macrolactin A Is Mediated through the β-Catenin Destruction Complex via the Suppression of Tankyrase and PI3K/Akt.
    Regmi SC, Park SY, Kim SJ, Banskota S, Shah S, Kim DH, Kim JA.
    PLoS One; 2015 Dec 02; 10(11):e0141753. PubMed ID: 26544726
    [Abstract] [Full Text] [Related]

  • 19. Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.
    Bao R, Christova T, Song S, Angers S, Yan X, Attisano L.
    PLoS One; 2012 Dec 02; 7(11):e48670. PubMed ID: 23144924
    [Abstract] [Full Text] [Related]

  • 20. Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling.
    Riccio AA, McCauley M, Langelier MF, Pascal JM.
    Structure; 2016 Sep 06; 24(9):1573-81. PubMed ID: 27499439
    [Abstract] [Full Text] [Related]

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