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194 related items for PubMed ID: 27494235

  • 1. Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action.
    Huang X, Huang R, Gou S, Wang Z, Liao Z, Wang H.
    Bioconjug Chem; 2016 Sep 21; 27(9):2132-48. PubMed ID: 27494235
    [Abstract] [Full Text] [Related]

  • 2. Dual-targeting antitumor conjugates derived from platinum(IV) prodrugs and microtubule inhibitor CA-4 significantly exhibited potent ability to overcome cisplatin resistance.
    Huang X, Wang M, Wang C, Hu W, You Q, Yang Y, Yu C, Liao Z, Gou S, Wang H.
    Bioorg Chem; 2019 Nov 21; 92():103236. PubMed ID: 31494328
    [Abstract] [Full Text] [Related]

  • 3. Platinum(IV) complexes conjugated with phenstatin analogue as inhibitors of microtubule polymerization and reverser of multidrug resistance.
    Huang X, Huang R, Gou S, Wang Z, Liao Z, Wang H.
    Bioorg Med Chem; 2017 Sep 01; 25(17):4686-4700. PubMed ID: 28728896
    [Abstract] [Full Text] [Related]

  • 4. Pt(IV) prodrugs containing microtubule inhibitors displayed potent antitumor activity and ability to overcome cisplatin resistance.
    Li L, Huang X, Huang R, Gou S, Wang Z, Wang H.
    Eur J Med Chem; 2018 Aug 05; 156():666-679. PubMed ID: 30031977
    [Abstract] [Full Text] [Related]

  • 5. 4,5-Diaryl-3H-1,2-dithiole-3-thiones and related compounds as combretastatin A-4/oltipraz hybrids: Synthesis, molecular modelling and evaluation as antiproliferative agents and inhibitors of tubulin.
    Wang Z, Qi H, Shen Q, Lu G, Li M, Bao K, Wu Y, Zhang W.
    Eur J Med Chem; 2016 Oct 21; 122():520-529. PubMed ID: 27428395
    [Abstract] [Full Text] [Related]

  • 6. Pyrrolotetrazinones deazaanalogues of temozolomide induce apoptosis in Jurkat cell line: involvement of tubulin polymerization inhibition.
    Viola G, Cecconet L, Leszl A, Basso G, Brun P, Salvador A, Dall'Acqua F, Diana P, Barraja P, Cirrincione G.
    Cancer Chemother Pharmacol; 2009 Nov 21; 64(6):1235-51. PubMed ID: 19363609
    [Abstract] [Full Text] [Related]

  • 7. Targeting RAS-RAF pathway significantly improves antitumor activity of Rigosertib-derived platinum(IV) complexes and overcomes cisplatin resistance.
    Liu Z, Wang M, Wang H, Fang L, Gou S.
    Eur J Med Chem; 2020 May 15; 194():112269. PubMed ID: 32248002
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers.
    Kamal A, Shaik B, Nayak VL, Nagaraju B, Kapure JS, Shaheer Malik M, Shaik TB, Prasad B.
    Bioorg Med Chem; 2014 Oct 01; 22(19):5155-67. PubMed ID: 25192811
    [Abstract] [Full Text] [Related]

  • 9. Combretastatin A-4 derived 5-(1-methyl-4-phenyl-imidazol-5-yl)indoles with superior cytotoxic and anti-vascular effects on chemoresistant cancer cells and tumors.
    Mahal K, Biersack B, Schruefer S, Resch M, Ficner R, Schobert R, Mueller T.
    Eur J Med Chem; 2016 Aug 08; 118():9-20. PubMed ID: 27116710
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and biological evaluation of novel pyrano[3,2-c]carbazole derivatives as anti-tumor agents inducing apoptosis via tubulin polymerization inhibition.
    Padmaja P, Koteswara Rao G, Indrasena A, Subba Reddy BV, Patel N, Shaik AB, Reddy N, Dubey PK, Bhadra MP.
    Org Biomol Chem; 2015 Feb 07; 13(5):1404-14. PubMed ID: 25467166
    [Abstract] [Full Text] [Related]

  • 11. Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues.
    Mustafa M, Abdelhamid D, Abdelhafez EMN, Ibrahim MAA, Gamal-Eldeen AM, Aly OM.
    Eur J Med Chem; 2017 Dec 01; 141():293-305. PubMed ID: 29031074
    [Abstract] [Full Text] [Related]

  • 12. Synthesis of phenstatin/isocombretastatin-chalcone conjugates as potent tubulin polymerization inhibitors and mitochondrial apoptotic inducers.
    Kamal A, Kumar GB, Vishnuvardhan MV, Shaik AB, Reddy VS, Mahesh R, Sayeeda IB, Kapure JS.
    Org Biomol Chem; 2015 Apr 07; 13(13):3963-81. PubMed ID: 25721862
    [Abstract] [Full Text] [Related]

  • 13. Oxazole-Bridged Combretastatin A-4 Derivatives with Tethered Hydroxamic Acids: Structure⁻Activity Relations of New Inhibitors of HDAC and/or Tubulin Function.
    Schmitt F, Gosch LC, Dittmer A, Rothemund M, Mueller T, Schobert R, Biersack B, Volkamer A, Höpfner M.
    Int J Mol Sci; 2019 Jan 17; 20(2):. PubMed ID: 30658435
    [Abstract] [Full Text] [Related]

  • 14. Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety.
    Chaudhary V, Venghateri JB, Dhaked HP, Bhoyar AS, Guchhait SK, Panda D.
    J Med Chem; 2016 Apr 14; 59(7):3439-51. PubMed ID: 26938120
    [Abstract] [Full Text] [Related]

  • 15. Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors.
    Khelifi I, Naret T, Renko D, Hamze A, Bernadat G, Bignon J, Lenoir C, Dubois J, Brion JD, Provot O, Alami M.
    Eur J Med Chem; 2017 Feb 15; 127():1025-1034. PubMed ID: 28166995
    [Abstract] [Full Text] [Related]

  • 16. Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions.
    Savino S, Marzano C, Gandin V, Hoeschele JD, Natile G, Margiotta N.
    Int J Mol Sci; 2018 Jul 14; 19(7):. PubMed ID: 30011897
    [Abstract] [Full Text] [Related]

  • 17. Combretastatin linked 1,3,4-oxadiazole conjugates as a Potent Tubulin Polymerization inhibitors.
    Kamal A, Srikanth PS, Vishnuvardhan MV, Kumar GB, Suresh Babu K, Hussaini SM, Kapure JS, Alarifi A.
    Bioorg Chem; 2016 Apr 14; 65():126-36. PubMed ID: 26943479
    [Abstract] [Full Text] [Related]

  • 18. Dual-targeting antitumor hybrids derived from Pt(IV) species and millepachine analogues.
    Huang X, Hua S, Huang R, Liu Z, Gou S, Wang Z, Liao Z, Wang H.
    Eur J Med Chem; 2018 Mar 25; 148():1-25. PubMed ID: 29448138
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.
    Romagnoli R, Baraldi PG, Cruz-Lopez O, Lopez Cara C, Carrion MD, Brancale A, Hamel E, Chen L, Bortolozzi R, Basso G, Viola G.
    J Med Chem; 2010 May 27; 53(10):4248-58. PubMed ID: 20420439
    [Abstract] [Full Text] [Related]

  • 20. Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.
    Rasolofonjatovo E, Provot O, Hamze A, Rodrigo J, Bignon J, Wdzieczak-Bakala J, Desravines D, Dubois J, Brion JD, Alami M.
    Eur J Med Chem; 2012 Jun 27; 52():22-32. PubMed ID: 22449653
    [Abstract] [Full Text] [Related]

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