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348 related items for PubMed ID: 27506270

  • 1. Mannitol/l-Arginine-Based Formulation Systems for Freeze Drying of Protein Pharmaceuticals: Effect of the l-Arginine Counter Ion and Formulation Composition on the Formulation Properties and the Physical State of Mannitol.
    Stärtzel P, Gieseler H, Gieseler M, Abdul-Fattah AM, Adler M, Mahler HC, Goldbach P.
    J Pharm Sci; 2016 Oct; 105(10):3123-3135. PubMed ID: 27506270
    [Abstract] [Full Text] [Related]

  • 2. Freeze-Drying of L-Arginine/Sucrose-Based Protein Formulations, Part 2: Optimization of Formulation Design and Freeze-Drying Process Conditions for an L-Arginine Chloride-Based Protein Formulation System.
    Stärtzel P, Gieseler H, Gieseler M, Abdul-Fattah AM, Adler M, Mahler HC, Goldbach P.
    J Pharm Sci; 2015 Dec; 104(12):4241-4256. PubMed ID: 26422647
    [Abstract] [Full Text] [Related]

  • 3. Freeze drying of L-arginine/sucrose-based protein formulations, part I: influence of formulation and arginine counter ion on the critical formulation temperature, product performance and protein stability.
    Stärtzel P, Gieseler H, Gieseler M, Abdul-Fattah AM, Adler M, Mahler HC, Goldbach P.
    J Pharm Sci; 2015 Jul; 104(7):2345-58. PubMed ID: 25994980
    [Abstract] [Full Text] [Related]

  • 4. Impact of fast and conservative freeze-drying on product quality of protein-mannitol-sucrose-glycerol lyophilizates.
    Horn J, Schanda J, Friess W.
    Eur J Pharm Biopharm; 2018 Jun; 127():342-354. PubMed ID: 29522899
    [Abstract] [Full Text] [Related]

  • 5. Effect of Arginine on the Aggregation of Protein in Freeze-Dried Formulations Containing Sugars and Polyol: 1-Formulation Development.
    Hackl E, Darkwah J, Smith G, Ermolina I.
    AAPS PharmSciTech; 2018 Feb; 19(2):896-911. PubMed ID: 29047017
    [Abstract] [Full Text] [Related]

  • 6. Crystallizing amino acids as bulking agents in freeze-drying.
    Horn J, Tolardo E, Fissore D, Friess W.
    Eur J Pharm Biopharm; 2018 Nov; 132():70-82. PubMed ID: 30201570
    [Abstract] [Full Text] [Related]

  • 7. Freeze-drying of mannitol-trehalose-sodium chloride-based formulations: the impact of annealing on dry layer resistance to mass transfer and cake structure.
    Lu X, Pikal MJ.
    Pharm Dev Technol; 2004 Nov; 9(1):85-95. PubMed ID: 15000469
    [Abstract] [Full Text] [Related]

  • 8. Mechanisms by which crystalline mannitol improves the reconstitution time of high concentration lyophilized protein formulations.
    Kulkarni SS, Suryanarayanan R, Rinella JV, Bogner RH.
    Eur J Pharm Biopharm; 2018 Oct; 131():70-81. PubMed ID: 30056143
    [Abstract] [Full Text] [Related]

  • 9. The effect of mannitol crystallization in mannitol-sucrose systems on LDH stability during freeze-drying.
    Al-Hussein A, Gieseler H.
    J Pharm Sci; 2012 Jul; 101(7):2534-44. PubMed ID: 22535541
    [Abstract] [Full Text] [Related]

  • 10. Impact of freezing procedure and annealing on the physico-chemical properties and the formation of mannitol hydrate in mannitol-sucrose-NaCl formulations.
    Hawe A, Friess W.
    Eur J Pharm Biopharm; 2006 Nov; 64(3):316-25. PubMed ID: 16875806
    [Abstract] [Full Text] [Related]

  • 11. Formulations of sugars with amino acids or mannitol--influence of concentration ratio on the properties of the freeze-concentrate and the lyophilizate.
    Lueckel B, Bodmer D, Helk B, Leuenberger H.
    Pharm Dev Technol; 1998 Aug; 3(3):325-36. PubMed ID: 9742553
    [Abstract] [Full Text] [Related]

  • 12. The Influence of Mannitol Hemihydrate on the Secondary Drying Dynamics of a Protein Formulation: A Case Study.
    Srinivasan JM, Wegiel LA, Hardwick LM, Nail SL.
    J Pharm Sci; 2017 Dec; 106(12):3583-3590. PubMed ID: 28867201
    [Abstract] [Full Text] [Related]

  • 13. Existence of a mannitol hydrate during freeze-drying and practical implications.
    Yu L, Milton N, Groleau EG, Mishra DS, Vansickle RE.
    J Pharm Sci; 1999 Feb; 88(2):196-8. PubMed ID: 9950638
    [Abstract] [Full Text] [Related]

  • 14. Well-plate freeze-drying: a high throughput platform for screening of physical properties of freeze-dried formulations.
    Trnka H, Rantanen J, Grohganz H.
    Pharm Dev Technol; 2015 Jan; 20(1):65-73. PubMed ID: 24417680
    [Abstract] [Full Text] [Related]

  • 15. Mannitol-sucrose mixtures--versatile formulations for protein lyophilization.
    Johnson RE, Kirchhoff CF, Gaud HT.
    J Pharm Sci; 2002 Apr; 91(4):914-22. PubMed ID: 11948529
    [Abstract] [Full Text] [Related]

  • 16. Crystallization of mannitol below Tg' during freeze-drying in binary and ternary aqueous systems.
    Pyne A, Surana R, Suryanarayanan R.
    Pharm Res; 2002 Jun; 19(6):901-8. PubMed ID: 12134964
    [Abstract] [Full Text] [Related]

  • 17. Solute crystallization in mannitol-glycine systems--implications on protein stabilization in freeze-dried formulations.
    Pyne A, Chatterjee K, Suryanarayanan R.
    J Pharm Sci; 2003 Nov; 92(11):2272-83. PubMed ID: 14603512
    [Abstract] [Full Text] [Related]

  • 18. Development of freeze-dried biosynthetic Factor VIII: I. A case study in the optimization of formulation.
    Jameel F, Tchessalov S, Bjornson E, Lu X, Besman M, Pikal M.
    Pharm Dev Technol; 2009 Nov; 14(6):687-97. PubMed ID: 19883259
    [Abstract] [Full Text] [Related]

  • 19. Physicochemical characterization of the freezing behavior of mannitol-human serum albumin formulations.
    Hawe A, Friess W.
    AAPS PharmSciTech; 2006 Nov; 7(4):94. PubMed ID: 17285745
    [Abstract] [Full Text] [Related]

  • 20. Using Texture Analysis Technique to Assess the Freeze-Dried Cakes in Vials.
    Hackl EV, Ermolina I.
    J Pharm Sci; 2016 Jul; 105(7):2073-85. PubMed ID: 27290623
    [Abstract] [Full Text] [Related]

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