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135 related items for PubMed ID: 27517805

  • 1. Conjugates of podophyllotoxin and norcantharidin as dual inhibitors of topoisomeraseⅡ and protein phosphatase 2A.
    Tang ZB, Chen YZ, Zhao J, Guan XW, Bo YX, Chen SW, Hui L.
    Eur J Med Chem; 2016 Nov 10; 123():568-576. PubMed ID: 27517805
    [Abstract] [Full Text] [Related]

  • 2. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.
    Zhao W, Chen L, Li HM, Wang DJ, Li DS, Chen T, Yuan ZP, Tang YJ.
    Bioorg Med Chem; 2014 Jun 01; 22(11):2998-3007. PubMed ID: 24775914
    [Abstract] [Full Text] [Related]

  • 3. Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition.
    Hill TA, Stewart SG, Gordon CP, Ackland SP, Gilbert J, Sauer B, Sakoff JA, McCluskey A.
    ChemMedChem; 2008 Dec 01; 3(12):1878-92. PubMed ID: 19025735
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis and anti-cancer activity evaluation of podophyllotoxin-norcantharidin hybrid drugs.
    Han HW, Qiu HY, Hu C, Sun WX, Yang RW, Qi JL, Wang XM, Lu GH, Yang YH.
    Bioorg Med Chem Lett; 2016 Jul 15; 26(14):3237-3242. PubMed ID: 27262599
    [Abstract] [Full Text] [Related]

  • 5. One-pot synthesis of podophyllotoxin-thiourea congeners by employing NH₂SO₃H/NaI: Anticancer activity, DNA topoisomerase-II inhibition, and apoptosis inducing agents.
    Shankaraiah N, Kumar NP, Amula SB, Nekkanti S, Jeengar MK, Naidu VG, Reddy TS, Kamal A.
    Bioorg Med Chem Lett; 2015 Oct 01; 25(19):4239-44. PubMed ID: 26292628
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and biological evaluation of norcantharidin derivatives as protein phosphatase-1 inhibitors.
    Zhao J, Guan XW, Chen SW, Hui L.
    Bioorg Med Chem Lett; 2015 Jan 15; 25(2):363-6. PubMed ID: 25466711
    [Abstract] [Full Text] [Related]

  • 7. One-pot synthesis and biological evaluation of N-(aminosulfonyl)-4-podophyllotoxin carbamates as potential anticancer agents.
    Xu XH, Guan XW, Feng SL, Ma YZ, Chen SW, Hui L.
    Bioorg Med Chem Lett; 2017 Jul 01; 27(13):2890-2894. PubMed ID: 28512026
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and biological evaluation of 4β-(thiazol-2-yl)amino-4'-O-demethyl-4-deoxypodophyllotoxins as topoisomerase-II inhibitors.
    Sang CY, Tian HZ, Chen Y, Liu JF, Chen SW, Hui L.
    Bioorg Med Chem Lett; 2018 Jan 15; 28(2):71-76. PubMed ID: 29248296
    [Abstract] [Full Text] [Related]

  • 9. Synthesis of podophyllotoxin linked β-carboline congeners as potential anticancer agents and DNA topoisomerase II inhibitors.
    Sathish M, Kavitha B, Nayak VL, Tangella Y, Ajitha A, Nekkanti S, Alarifi A, Shankaraiah N, Nagesh N, Kamal A.
    Eur J Med Chem; 2018 Jan 20; 144():557-571. PubMed ID: 29289881
    [Abstract] [Full Text] [Related]

  • 10. Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives.
    Li WQ, Wang XL, Qian K, Liu YQ, Wang CY, Yang L, Tian J, Morris-Natschke SL, Zhou XW, Lee KH.
    Bioorg Med Chem; 2013 Apr 15; 21(8):2363-2369. PubMed ID: 23490151
    [Abstract] [Full Text] [Related]

  • 11. Synthesis of hybrid 4-deoxypodophyllotoxin-5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest.
    Guan XW, Xu XH, Feng SL, Tang ZB, Chen SW, Hui L.
    Bioorg Med Chem Lett; 2016 Mar 15; 26(6):1561-1566. PubMed ID: 26873416
    [Abstract] [Full Text] [Related]

  • 12. Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4'-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways.
    Xiao L, Zhao W, Li HM, Wan DJ, Li DS, Chen T, Tang YJ.
    Eur J Med Chem; 2014 Jun 10; 80():267-77. PubMed ID: 24793877
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7.
    Huang WT, Liu J, Liu JF, Hui L, Ding YL, Chen SW.
    Eur J Med Chem; 2012 Mar 10; 49():48-54. PubMed ID: 22244588
    [Abstract] [Full Text] [Related]

  • 14. HY-2, a novel DNA topoisomerase II inhibitor, induces G2/M cell cycle arrest in HCT-116 cells.
    Wu Z, Zhao Y, Zhang Y, Zhu L.
    J Chemother; 2014 Dec 10; 26(6):342-7. PubMed ID: 24188177
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)-podophyllotoxin derivatives.
    Ren J, Wu L, Xin WQ, Chen X, Hu K.
    Bioorg Med Chem Lett; 2012 Jul 15; 22(14):4778-82. PubMed ID: 22687745
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and anticancer activity of dichloroplatinum(II) complexes of podophyllotoxin.
    Liu X, Zhang LL, Xu XH, Hui L, Zhang JB, Chen SW.
    Bioorg Med Chem Lett; 2013 Jul 01; 23(13):3780-4. PubMed ID: 23711918
    [Abstract] [Full Text] [Related]

  • 17. SAR analysis and biological studies of synthesized podophyllum derivates obtained by N linkage modification at C-4 position.
    Wang H, Tang L, Tang Y, Yuan Z.
    Bioorg Med Chem; 2014 Nov 01; 22(21):6183-92. PubMed ID: 25282651
    [Abstract] [Full Text] [Related]

  • 18. Heterocyclic substituted cantharidin and norcantharidin analogues--synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity.
    Hill TA, Stewart SG, Sauer B, Gilbert J, Ackland SP, Sakoff JA, McCluskey A.
    Bioorg Med Chem Lett; 2007 Jun 15; 17(12):3392-7. PubMed ID: 17451951
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and evaluation of the cell cycle arrest and CT DNA interaction properties of 4β-amino-4'-O-demethyl-4-deoxypodophyllotoxins.
    Liu JF, Sang CY, Qin WW, Zhao J, Hui L, Ding YL, Chen SW.
    Bioorg Med Chem; 2013 Nov 15; 21(22):6948-55. PubMed ID: 24095019
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and cytotoxic activity on human cancer cells of carbamate derivatives of 4β-(1,2,3-triazol-1-yl)podophyllotoxin.
    Liu JF, Sang CY, Xu XH, Zhang LL, Yang X, Hui L, Zhang JB, Chen SW.
    Eur J Med Chem; 2013 Jun 15; 64():621-8. PubMed ID: 23711769
    [Abstract] [Full Text] [Related]

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