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223 related items for PubMed ID: 27522507

  • 1. Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
    Kantsadi AL, Bokor É, Kun S, Stravodimos GA, Chatzileontiadou DSM, Leonidas DD, Juhász-Tóth É, Szakács A, Batta G, Docsa T, Gergely P, Somsák L.
    Eur J Med Chem; 2016 Nov 10; 123():737-745. PubMed ID: 27522507
    [Abstract] [Full Text] [Related]

  • 2. A multidisciplinary study of 3-(β-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors.
    Kun S, Begum J, Kyriakis E, Stamati ECV, Barkas TA, Szennyes E, Bokor É, Szabó KE, Stravodimos GA, Sipos Á, Docsa T, Gergely P, Moffatt C, Patraskaki MS, Kokolaki MC, Gkerdi A, Skamnaki VT, Leonidas DD, Somsák L, Hayes JM.
    Eur J Med Chem; 2018 Mar 10; 147():266-278. PubMed ID: 29453094
    [Abstract] [Full Text] [Related]

  • 3. C-Glucopyranosyl-1,2,4-triazol-5-ones: synthesis and inhibition of glycogen phosphorylase.
    Bokor É, Széles Z, Docsa T, Gergely P, Somsák L.
    Carbohydr Res; 2016 Jun 24; 429():128-34. PubMed ID: 26818133
    [Abstract] [Full Text] [Related]

  • 4. Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.
    Bokor É, Kyriakis E, Solovou TGA, Koppány C, Kantsadi AL, Szabó KE, Szakács A, Stravodimos GA, Docsa T, Skamnaki VT, Zographos SE, Gergely P, Leonidas DD, Somsák L.
    J Med Chem; 2017 Nov 22; 60(22):9251-9262. PubMed ID: 28925695
    [Abstract] [Full Text] [Related]

  • 5. New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase.
    Kun S, Bokor É, Varga G, Szőcs B, Páhi A, Czifrák K, Tóth M, Juhász L, Docsa T, Gergely P, Somsák L.
    Eur J Med Chem; 2014 Apr 09; 76():567-79. PubMed ID: 24608000
    [Abstract] [Full Text] [Related]

  • 6. Synthesis, In Silico and Kinetics Evaluation of N-(β-d-glucopyranosyl)-2-arylimidazole-4(5)-carboxamides and N-(β-d-glucopyranosyl)-4(5)-arylimidazole-2-carboxamides as Glycogen Phosphorylase Inhibitors.
    Homolya L, Mathomes RT, Varga L, Docsa T, Juhász L, Hayes JM, Somsák L.
    Int J Mol Sci; 2024 Apr 23; 25(9):. PubMed ID: 38731811
    [Abstract] [Full Text] [Related]

  • 7. Probing the β-pocket of the active site of human liver glycogen phosphorylase with 3-(C-β-d-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors.
    Kyriakis E, Solovou TGA, Kun S, Czifrák K, Szőcs B, Juhász L, Bokor É, Stravodimos GA, Kantsadi AL, Chatzileontiadou DSM, Skamnaki VT, Somsák L, Leonidas DD.
    Bioorg Chem; 2018 Apr 23; 77():485-493. PubMed ID: 29454281
    [Abstract] [Full Text] [Related]

  • 8. Crystallographic and computational studies on 4-phenyl-N-(beta-D-glucopyranosyl)-1H-1,2,3-triazole-1-acetamide, an inhibitor of glycogen phosphorylase: comparison with alpha-D-glucose, N-acetyl-beta-D-glucopyranosylamine and N-benzoyl-N'-beta-D-glucopyranosyl urea binding.
    Alexacou KM, Hayes JM, Tiraidis C, Zographos SE, Leonidas DD, Chrysina ED, Archontis G, Oikonomakos NG, Paul JV, Varghese B, Loganathan D.
    Proteins; 2008 May 15; 71(3):1307-23. PubMed ID: 18041758
    [Abstract] [Full Text] [Related]

  • 9. van der Waals interactions govern C-β-d-glucopyranosyl triazoles' nM inhibitory potency in human liver glycogen phosphorylase.
    Kantsadi AL, Stravodimos GA, Kyriakis E, Chatzileontiadou DSM, Solovou TGA, Kun S, Bokor É, Somsák L, Leonidas DD.
    J Struct Biol; 2017 Jul 15; 199(1):57-67. PubMed ID: 28483603
    [Abstract] [Full Text] [Related]

  • 10. N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
    Nagy V, Felföldi N, Kónya B, Praly JP, Docsa T, Gergely P, Chrysina ED, Tiraidis C, Kosmopoulou MN, Alexacou KM, Konstantakaki M, Leonidas DD, Zographos SE, Oikonomakos NG, Kozmon S, Tvaroška I, Somsák L.
    Bioorg Med Chem; 2012 Mar 01; 20(5):1801-16. PubMed ID: 22325154
    [Abstract] [Full Text] [Related]

  • 11. Synthesis of New C- and N-β-d-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase.
    Kun S, Bokor É, Sipos Á, Docsa T, Somsák L.
    Molecules; 2018 Mar 15; 23(3):. PubMed ID: 29543771
    [Abstract] [Full Text] [Related]

  • 12. Synthesis of C-β-d-glucopyranosyl derivatives of some fused azoles for the inhibition of glycogen phosphorylase.
    Szennyes E, Bokor É, Docsa T, Sipos Á, Somsák L.
    Carbohydr Res; 2019 Jan 15; 472():33-41. PubMed ID: 30453096
    [Abstract] [Full Text] [Related]

  • 13. Identification of C-β-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies.
    Barr D, Szennyes E, Bokor É, Al-Oanzi ZH, Moffatt C, Kun S, Docsa T, Sipos Á, Davies MP, Mathomes RT, Snape TJ, Agius L, Somsák L, Hayes JM.
    ACS Chem Biol; 2019 Jul 19; 14(7):1460-1470. PubMed ID: 31243960
    [Abstract] [Full Text] [Related]

  • 14. Synthesis of heterocyclic N-(β-D-glucopyranosyl)carboxamides for inhibition of glycogen phosphorylase.
    Kónya B, Docsa T, Gergely P, Somsák L.
    Carbohydr Res; 2012 Apr 01; 351():56-63. PubMed ID: 22365837
    [Abstract] [Full Text] [Related]

  • 15. Synthesis, enzyme kinetics and computational evaluation of N-(β-D-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors.
    Polyák M, Varga G, Szilágyi B, Juhász L, Docsa T, Gergely P, Begum J, Hayes JM, Somsák L.
    Bioorg Med Chem; 2013 Sep 15; 21(18):5738-47. PubMed ID: 23938052
    [Abstract] [Full Text] [Related]

  • 16. Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: comparison of chrysin and flavopiridol.
    Tsitsanou KE, Hayes JM, Keramioti M, Mamais M, Oikonomakos NG, Kato A, Leonidas DD, Zographos SE.
    Food Chem Toxicol; 2013 Nov 15; 61():14-27. PubMed ID: 23279842
    [Abstract] [Full Text] [Related]

  • 17. The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.
    Kyriakis E, Karra AG, Papaioannou O, Solovou T, Skamnaki VT, Liggri PGV, Zographos SE, Szennyes E, Bokor É, Kun S, Psarra AG, Somsák L, Leonidas DD.
    Bioorg Med Chem; 2020 Jan 01; 28(1):115196. PubMed ID: 31767404
    [Abstract] [Full Text] [Related]

  • 18. Synthesis of 2-(β-D-glucopyranosyl)-5-(substituted-amino)-1,3,4-oxa- and -thiadiazoles for the inhibition of glycogen phosphorylase.
    Szőcs B, Tóth M, Docsa T, Gergely P, Somsák L.
    Carbohydr Res; 2013 Nov 15; 381():187-95. PubMed ID: 23582340
    [Abstract] [Full Text] [Related]

  • 19. Synthesis of substituted 2-(β-D-glucopyranosyl)-benzimidazoles and their evaluation as inhibitors of glycogen phosphorylase.
    Bokor É, Szilágyi E, Docsa T, Gergely P, Somsák L.
    Carbohydr Res; 2013 Nov 15; 381():179-86. PubMed ID: 23419607
    [Abstract] [Full Text] [Related]

  • 20. Glucopyranosylidene-spiro-iminothiazolidinone, a new bicyclic ring system: synthesis, derivatization, and evaluation for inhibition of glycogen phosphorylase by enzyme kinetic and crystallographic methods.
    Czifrák K, Páhi A, Deák S, Kiss-Szikszai A, Kövér KE, Docsa T, Gergely P, Alexacou KM, Papakonstantinou M, Leonidas DD, Zographos SE, Chrysina ED, Somsák L.
    Bioorg Med Chem; 2014 Aug 01; 22(15):4028-41. PubMed ID: 25009003
    [Abstract] [Full Text] [Related]

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