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Journal Abstract Search

565 related items for PubMed ID: 27535970

  • 1. Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models.
    Logsdon DP, Grimard M, Luo M, Shahda S, Jiang Y, Tong Y, Yu Z, Zyromski N, Schipani E, Carta F, Supuran CT, Korc M, Ivan M, Kelley MR, Fishel ML.
    Mol Cancer Ther; 2016 Nov; 15(11):2722-2732. PubMed ID: 27535970
    [Abstract] [Full Text] [Related]

  • 2. Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival.
    Logsdon DP, Shah F, Carta F, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML.
    Sci Rep; 2018 Sep 13; 8(1):13759. PubMed ID: 30214007
    [Abstract] [Full Text] [Related]

  • 3. APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.
    Cardoso AA, Jiang Y, Luo M, Reed AM, Shahda S, He Y, Maitra A, Kelley MR, Fishel ML.
    PLoS One; 2012 Sep 13; 7(10):e47462. PubMed ID: 23094050
    [Abstract] [Full Text] [Related]

  • 4. Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia.
    McDonald PC, Chafe SC, Brown WS, Saberi S, Swayampakula M, Venkateswaran G, Nemirovsky O, Gillespie JA, Karasinska JM, Kalloger SE, Supuran CT, Schaeffer DF, Bashashati A, Shah SP, Topham JT, Yapp DT, Li J, Renouf DJ, Stanger BZ, Dedhar S.
    Gastroenterology; 2019 Sep 13; 157(3):823-837. PubMed ID: 31078621
    [Abstract] [Full Text] [Related]

  • 5. Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth.
    Fishel ML, Jiang Y, Rajeshkumar NV, Scandura G, Sinn AL, He Y, Shen C, Jones DR, Pollok KE, Ivan M, Maitra A, Kelley MR.
    Mol Cancer Ther; 2011 Sep 13; 10(9):1698-708. PubMed ID: 21700832
    [Abstract] [Full Text] [Related]

  • 6. Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.
    Fishel ML, Wu X, Devlin CM, Logsdon DP, Jiang Y, Luo M, He Y, Yu Z, Tong Y, Lipking KP, Maitra A, Rajeshkumar NV, Scandura G, Kelley MR, Ivan M.
    J Biol Chem; 2015 Jan 30; 290(5):3057-68. PubMed ID: 25492865
    [Abstract] [Full Text] [Related]

  • 7. Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential.
    Knudsen ES, Balaji U, Freinkman E, McCue P, Witkiewicz AK.
    Oncotarget; 2016 Nov 29; 7(48):78396-78411. PubMed ID: 27623078
    [Abstract] [Full Text] [Related]

  • 8. Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration.
    Zou GM, Maitra A.
    Mol Cancer Ther; 2008 Jul 29; 7(7):2012-21. PubMed ID: 18645011
    [Abstract] [Full Text] [Related]

  • 9. In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer.
    Mijit M, Kpenu E, Chowdhury NN, Gampala S, Wireman R, Liu S, Babb O, Georgiadis MM, Wan J, Fishel ML, Kelley MR.
    Redox Biol; 2024 Feb 29; 69():102977. PubMed ID: 38056311
    [Abstract] [Full Text] [Related]

  • 10. Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells.
    Mijit M, Liu S, Sishtla K, Hartman GD, Wan J, Corson TW, Kelley MR.
    Int J Mol Sci; 2023 Jan 06; 24(2):. PubMed ID: 36674619
    [Abstract] [Full Text] [Related]

  • 11. Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer.
    Fishel ML, Xia H, McGeown J, McIlwain DW, Elbanna M, Craft AA, Kaimakliotis HZ, Sandusky GE, Zhang C, Pili R, Kelley MR, Jerde TJ.
    Mol Cancer Ther; 2019 Nov 06; 18(11):1947-1960. PubMed ID: 31413178
    [Abstract] [Full Text] [Related]

  • 12. APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma - characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing.
    Shah F, Goossens E, Atallah NM, Grimard M, Kelley MR, Fishel ML.
    Mol Oncol; 2017 Dec 06; 11(12):1711-1732. PubMed ID: 28922540
    [Abstract] [Full Text] [Related]

  • 13. Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1.
    Luo M, Delaplane S, Jiang A, Reed A, He Y, Fishel M, Nyland RL, Borch RF, Qiao X, Georgiadis MM, Kelley MR.
    Antioxid Redox Signal; 2008 Nov 06; 10(11):1853-67. PubMed ID: 18627350
    [Abstract] [Full Text] [Related]

  • 14. Ape1 regulates WNT/β-catenin signaling through its redox functional domain in pancreatic cancer cells.
    Jiang S, Zhu L, Tang H, Zhang M, Chen Z, Fei J, Han B, Zou GM.
    Int J Oncol; 2015 Aug 06; 47(2):610-20. PubMed ID: 26081414
    [Abstract] [Full Text] [Related]

  • 15. CA9 and PRELID2; hypoxia-responsive potential therapeutic targets for pancreatic ductal adenocarcinoma as per bioinformatics analyses.
    Imanishi M, Inoue T, Fukushima K, Yamashita R, Nakayama R, Nojima M, Kondo K, Gomi Y, Tsunematsu H, Goto K, Miyamoto L, Funamoto M, Denda M, Ishizawa K, Otaka A, Fujino H, Ikeda Y, Tsuchiya K.
    J Pharmacol Sci; 2023 Dec 06; 153(4):232-242. PubMed ID: 37973221
    [Abstract] [Full Text] [Related]

  • 16. Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1).
    Laev SS, Salakhutdinov NF, Lavrik OI.
    Bioorg Med Chem; 2017 May 01; 25(9):2531-2544. PubMed ID: 28161249
    [Abstract] [Full Text] [Related]

  • 17. Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells.
    Parks SK, Cormerais Y, Durivault J, Pouyssegur J.
    Oncotarget; 2017 Feb 07; 8(6):10225-10237. PubMed ID: 28055960
    [Abstract] [Full Text] [Related]

  • 18. Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma.
    Sahu N, Chan E, Chu F, Pham T, Koeppen H, Forrest W, Merchant M, Settleman J.
    Mol Cancer Ther; 2017 Sep 07; 16(9):1729-1738. PubMed ID: 28619758
    [Abstract] [Full Text] [Related]

  • 19. P4HA1/HIF1α feedback loop drives the glycolytic and malignant phenotypes of pancreatic cancer.
    Cao XP, Cao Y, Li WJ, Zhang HH, Zhu ZM.
    Biochem Biophys Res Commun; 2019 Aug 27; 516(3):606-612. PubMed ID: 31239153
    [Abstract] [Full Text] [Related]

  • 20. The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target.
    Fishel ML, Kelley MR.
    Mol Aspects Med; 2007 Aug 27; 28(3-4):375-95. PubMed ID: 17560642
    [Abstract] [Full Text] [Related]

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