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Journal Abstract Search

632 related items for PubMed ID: 27541263

  • 1. Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study.
    Lamie PF, Ali WAM, Bazgier V, Rárová L.
    Eur J Med Chem; 2016 Nov 10; 123():803-813. PubMed ID: 27541263
    [Abstract] [Full Text] [Related]

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  • 3. Discovery of small molecule acting as multitarget inhibitor of colorectal cancer by simultaneous blocking of the key COX-2, 5-LOX and PIM-1 kinase enzymes.
    El-Miligy MMM, Al-Kubeisi AK, El-Zemity SR, Nassra RA, Abu-Serie MM, Hazzaa AA.
    Bioorg Chem; 2021 Oct 10; 115():105171. PubMed ID: 34303896
    [Abstract] [Full Text] [Related]

  • 4. Novel N-substituted 5-aminosalicylamides as dual inhibitors of cyclooxygenase and 5-lipoxygenase enzymes: Synthesis, biological evaluation and docking study.
    El-Nagar MKS, Abdu-Allah HHM, Salem OIA, Kafafy AN, Farghaly HSM.
    Bioorg Chem; 2018 Aug 10; 78():80-93. PubMed ID: 29550533
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors.
    Lai Y, Ma L, Huang W, Yu X, Zhang Y, Ji H, Tian J.
    Bioorg Med Chem Lett; 2010 Dec 15; 20(24):7349-53. PubMed ID: 21055929
    [Abstract] [Full Text] [Related]

  • 6. Pyrazole-hydrazone derivatives as anti-inflammatory agents: Design, synthesis, biological evaluation, COX-1,2/5-LOX inhibition and docking study.
    Abdelgawad MA, Labib MB, Abdel-Latif M.
    Bioorg Chem; 2017 Oct 15; 74():212-220. PubMed ID: 28865292
    [Abstract] [Full Text] [Related]

  • 7. New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.
    El-Miligy MMM, Hazzaa AA, El-Messmary H, Nassra RA, El-Hawash SAM.
    Bioorg Chem; 2017 Jun 15; 72():102-115. PubMed ID: 28390993
    [Abstract] [Full Text] [Related]

  • 8. Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies.
    Abdelgawad MA, Labib MB, Ali WAM, Kamel G, Azouz AA, El-Nahass ES.
    Bioorg Chem; 2018 Aug 15; 78():103-114. PubMed ID: 29550530
    [Abstract] [Full Text] [Related]

  • 9. Design, synthesis, biological evaluation and docking study of novel indole-2-amide as anti-inflammatory agents with dual inhibition of COX and 5-LOX.
    Huang Y, Zhang B, Li J, Liu H, Zhang Y, Yang Z, Liu W.
    Eur J Med Chem; 2019 Oct 15; 180():41-50. PubMed ID: 31299586
    [Abstract] [Full Text] [Related]

  • 10. 1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity.
    Naaz F, Preeti Pallavi MC, Shafi S, Mulakayala N, Shahar Yar M, Sampath Kumar HM.
    Bioorg Chem; 2018 Dec 15; 81():1-20. PubMed ID: 30081353
    [Abstract] [Full Text] [Related]

  • 11. Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.
    Singh P, Prasher P, Dhillon P, Bhatti R.
    Eur J Med Chem; 2015 Jun 05; 97():104-23. PubMed ID: 25956953
    [Abstract] [Full Text] [Related]

  • 12. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.
    Reddy MV, Billa VK, Pallela VR, Mallireddigari MR, Boominathan R, Gabriel JL, Reddy EP.
    Bioorg Med Chem; 2008 Apr 01; 16(7):3907-16. PubMed ID: 18272371
    [Abstract] [Full Text] [Related]

  • 13. Synthesis, biological evaluation and docking study of 1,3,4-thiadiazole-thiazolidinone hybrids as anti-inflammatory agents with dual inhibition of COX-2 and 15-LOX.
    Omar YM, Abdu-Allah HHM, Abdel-Moty SG.
    Bioorg Chem; 2018 Oct 01; 80():461-471. PubMed ID: 29986191
    [Abstract] [Full Text] [Related]

  • 14. Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity.
    Abdelrahman MH, Youssif BGM, Abdelgawad MA, Abdelazeem AH, Ibrahim HM, Moustafa AEGA, Treamblu L, Bukhari SNA.
    Eur J Med Chem; 2017 Feb 15; 127():972-985. PubMed ID: 27837994
    [Abstract] [Full Text] [Related]

  • 15. Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.
    Shen FQ, Wang ZC, Wu SY, Ren SZ, Man RJ, Wang BZ, Zhu HL.
    Bioorg Med Chem Lett; 2017 Aug 15; 27(16):3653-3660. PubMed ID: 28720504
    [Abstract] [Full Text] [Related]

  • 16. Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors.
    Gedawy EM, Kassab AE, El Kerdawy AM.
    Eur J Med Chem; 2020 Mar 01; 189():112066. PubMed ID: 31982653
    [Abstract] [Full Text] [Related]

  • 17. Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.
    Cai H, Huang X, Xu S, Shen H, Zhang P, Huang Y, Jiang J, Sun Y, Jiang B, Wu X, Yao H, Xu J.
    Eur J Med Chem; 2016 Jan 27; 108():89-103. PubMed ID: 26638042
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.
    Özadalı K, Özkanlı F, Jain S, Rao PP, Velázquez-Martínez CA.
    Bioorg Med Chem; 2012 May 01; 20(9):2912-22. PubMed ID: 22475926
    [Abstract] [Full Text] [Related]

  • 19. Design, synthesis and evaluation of novel diaryl-1,5-diazoles derivatives bearing morpholine as potent dual COX-2/5-LOX inhibitors and antitumor agents.
    Li Z, Wang ZC, Li X, Abbas M, Wu SY, Ren SZ, Liu QX, Liu Y, Chen PW, Duan YT, Lv PC, Zhu HL.
    Eur J Med Chem; 2019 May 01; 169():168-184. PubMed ID: 30877972
    [Abstract] [Full Text] [Related]

  • 20. Insight on novel oxindole conjugates adopting different anti-inflammatory investigations and quantitative evaluation.
    Said MF, Marie SM, Mohamed NM, Mahrouse MA, Moussa BA.
    Future Med Chem; 2024 May 01; 16(9):817-842. PubMed ID: 38634318
    [Abstract] [Full Text] [Related]

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