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Journal Abstract Search

325 related items for PubMed ID: 27598236

  • 1. High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity.
    Li DD, Chen WL, Wang ZH, Xie YY, Xu XL, Jiang ZY, Zhang XJ, You QD, Guo XK.
    Eur J Med Chem; 2016 Nov 29; 124():480-489. PubMed ID: 27598236
    [Abstract] [Full Text] [Related]

  • 2. Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction.
    Chen WL, Li DD, Chen X, Wang YZ, Xu JJ, Jiang ZY, You QD, Guo XK.
    Eur J Med Chem; 2020 Feb 15; 188():112027. PubMed ID: 31923859
    [Abstract] [Full Text] [Related]

  • 3. Structure-based design of ester compounds to inhibit MLL complex catalytic activity by targeting mixed lineage leukemia 1 (MLL1)-WDR5 interaction.
    Li DD, Wang ZH, Chen WL, Xie YY, You QD, Guo XK.
    Bioorg Med Chem; 2016 Nov 15; 24(22):6109-6118. PubMed ID: 27720555
    [Abstract] [Full Text] [Related]

  • 4. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).
    Getlik M, Smil D, Zepeda-Velázquez C, Bolshan Y, Poda G, Wu H, Dong A, Kuznetsova E, Marcellus R, Senisterra G, Dombrovski L, Hajian T, Kiyota T, Schapira M, Arrowsmith CH, Brown PJ, Vedadi M, Al-Awar R.
    J Med Chem; 2016 Mar 24; 59(6):2478-96. PubMed ID: 26958703
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  • 7. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
    Karatas H, Townsend EC, Cao F, Chen Y, Bernard D, Liu L, Lei M, Dou Y, Wang S.
    J Am Chem Soc; 2013 Jan 16; 135(2):669-82. PubMed ID: 23210835
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  • 8. Discovery of a potent MLL1 and WDR5 protein-protein interaction inhibitor with in vivo antitumor activity.
    Chen W, Chen X, Li D, Wang X, Long G, Jiang Z, You Q, Guo X.
    Eur J Med Chem; 2021 Nov 05; 223():113677. PubMed ID: 34225179
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16INK4a.
    Shimoda H, Doi S, Nakashima A, Sasaki K, Doi T, Masaki T.
    Kidney Int; 2019 Nov 05; 96(5):1162-1175. PubMed ID: 31570196
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  • 11. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
    Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, Dong A, Senisterra G, Stukalov A, Huber KVM, Schönegger A, Marcellus R, Bilban M, Bock C, Brown PJ, Zuber J, Bennett KL, Al-Awar R, Delwel R, Nerlov C, Arrowsmith CH, Superti-Furga G.
    Nat Chem Biol; 2015 Aug 05; 11(8):571-578. PubMed ID: 26167872
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  • 12. Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction.
    Karatas H, Townsend EC, Bernard D, Dou Y, Wang S.
    J Med Chem; 2010 Jul 22; 53(14):5179-85. PubMed ID: 20575550
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  • 13. Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.
    Cao F, Townsend EC, Karatas H, Xu J, Li L, Lee S, Liu L, Chen Y, Ouillette P, Zhu J, Hess JL, Atadja P, Lei M, Qin ZS, Malek S, Wang S, Dou Y.
    Mol Cell; 2014 Jan 23; 53(2):247-61. PubMed ID: 24389101
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  • 14. The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening.
    Ye X, Zhang R, Lian F, Zhang W, Lu W, Han J, Zhang N, Jin J, Luo C, Chen K, Ye F, Ding H.
    Bioorg Med Chem Lett; 2019 Feb 15; 29(4):638-645. PubMed ID: 30626558
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  • 15. Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
    Dharmarajan V, Lee JH, Patel A, Skalnik DG, Cosgrove MS.
    J Biol Chem; 2012 Aug 10; 287(33):27275-89. PubMed ID: 22665483
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  • 16. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
    Karatas H, Li Y, Liu L, Ji J, Lee S, Chen Y, Yang J, Huang L, Bernard D, Xu J, Townsend EC, Cao F, Ran X, Li X, Wen B, Sun D, Stuckey JA, Lei M, Dou Y, Wang S.
    J Med Chem; 2017 Jun 22; 60(12):4818-4839. PubMed ID: 28603984
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  • 18. Targeting human SET1/MLL family of proteins.
    Vedadi M, Blazer L, Eram MS, Barsyte-Lovejoy D, Arrowsmith CH, Hajian T.
    Protein Sci; 2017 Apr 22; 26(4):662-676. PubMed ID: 28160335
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  • 19. Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
    Alicea-Velázquez NL, Shinsky SA, Loh DM, Lee JH, Skalnik DG, Cosgrove MS.
    J Biol Chem; 2016 Oct 21; 291(43):22357-22372. PubMed ID: 27563068
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  • 20. Targeting protein-protein interaction between MLL1 and reciprocal proteins for leukemia therapy.
    Wang ZH, Li DD, Chen WL, You QD, Guo XK.
    Bioorg Med Chem; 2018 Jan 15; 26(2):356-365. PubMed ID: 29254892
    [Abstract] [Full Text] [Related]

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