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432 related items for PubMed ID: 27646000

  • 1. Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins.
    Cuny H, Kompella SN, Tae HS, Yu R, Adams DJ.
    J Biol Chem; 2016 Nov 04; 291(45):23779-23792. PubMed ID: 27646000
    [Abstract] [Full Text] [Related]

  • 2. Alanine scan of α-conotoxin RegIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist.
    Kompella SN, Hung A, Clark RJ, Marí F, Adams DJ.
    J Biol Chem; 2015 Jan 09; 290(2):1039-48. PubMed ID: 25411242
    [Abstract] [Full Text] [Related]

  • 3. Key residues in the nicotinic acetylcholine receptor β2 subunit contribute to α-conotoxin LvIA binding.
    Zhangsun D, Zhu X, Wu Y, Hu Y, Kaas Q, Craik DJ, McIntosh JM, Luo S.
    J Biol Chem; 2015 Apr 10; 290(15):9855-62. PubMed ID: 25713061
    [Abstract] [Full Text] [Related]

  • 4. Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor.
    Luo S, Akondi KB, Zhangsun D, Wu Y, Zhu X, Hu Y, Christensen S, Dowell C, Daly NL, Craik DJ, Wang CI, Lewis RJ, Alewood PF, Michael McIntosh J.
    J Biol Chem; 2010 Apr 16; 285(16):12355-66. PubMed ID: 20145249
    [Abstract] [Full Text] [Related]

  • 5. Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors.
    Grishin AA, Cuny H, Hung A, Clark RJ, Brust A, Akondi K, Alewood PF, Craik DJ, Adams DJ.
    J Biol Chem; 2013 Nov 29; 288(48):34428-42. PubMed ID: 24100032
    [Abstract] [Full Text] [Related]

  • 6. Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors.
    Hone AJ, Talley TT, Bobango J, Huidobro Melo C, Hararah F, Gajewiak J, Christensen S, Harvey PJ, Craik DJ, McIntosh JM.
    J Biol Chem; 2018 Nov 16; 293(46):17838-17852. PubMed ID: 30249616
    [Abstract] [Full Text] [Related]

  • 7. A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors.
    Luo S, Zhangsun D, Schroeder CI, Zhu X, Hu Y, Wu Y, Weltzin MM, Eberhard S, Kaas Q, Craik DJ, McIntosh JM, Whiteaker P.
    FASEB J; 2014 Apr 16; 28(4):1842-53. PubMed ID: 24398291
    [Abstract] [Full Text] [Related]

  • 8. RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs.
    Franco A, Kompella SN, Akondi KB, Melaun C, Daly NL, Luetje CW, Alewood PF, Craik DJ, Adams DJ, Marí F.
    Biochem Pharmacol; 2012 Feb 01; 83(3):419-26. PubMed ID: 22108175
    [Abstract] [Full Text] [Related]

  • 9. α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors.
    Wu Y, Zhangsun D, Zhu X, Kaas Q, Zhangsun M, Harvey PJ, Craik DJ, McIntosh JM, Luo S.
    J Med Chem; 2017 Jul 13; 60(13):5826-5833. PubMed ID: 28603989
    [Abstract] [Full Text] [Related]

  • 10. Rational Design of α-Conotoxin RegIIA Analogues Selectively Inhibiting the Human α3β2 Nicotinic Acetylcholine Receptor through Computational Scanning.
    Xu Q, Tae HS, Wang Z, Jiang T, Adams DJ, Yu R.
    ACS Chem Neurosci; 2020 Sep 16; 11(18):2804-2811. PubMed ID: 32649832
    [Abstract] [Full Text] [Related]

  • 11. α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition.
    Cuny H, Yu R, Tae HS, Kompella SN, Adams DJ.
    Br J Pharmacol; 2018 Jun 16; 175(11):1855-1868. PubMed ID: 28477355
    [Abstract] [Full Text] [Related]

  • 12. Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.
    Grishin AA, Wang CI, Muttenthaler M, Alewood PF, Lewis RJ, Adams DJ.
    J Biol Chem; 2010 Jul 16; 285(29):22254-63. PubMed ID: 20466726
    [Abstract] [Full Text] [Related]

  • 13. Molecular Basis for Differential Sensitivity of α-Conotoxin RegIIA at Rat and Human Neuronal Nicotinic Acetylcholine Receptors.
    Kompella SN, Cuny H, Hung A, Adams DJ.
    Mol Pharmacol; 2015 Dec 16; 88(6):993-1001. PubMed ID: 26438212
    [Abstract] [Full Text] [Related]

  • 14. Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB.
    Wu X, Tae HS, Huang YH, Adams DJ, Craik DJ, Kaas Q.
    Biochem Pharmacol; 2018 Sep 16; 155():288-297. PubMed ID: 30009767
    [Abstract] [Full Text] [Related]

  • 15. α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors.
    van Hout M, Valdes A, Christensen SB, Tran PT, Watkins M, Gajewiak J, Jensen AA, Olivera BM, McIntosh JM.
    Neuropharmacology; 2019 Oct 16; 157():107691. PubMed ID: 31255696
    [Abstract] [Full Text] [Related]

  • 16. Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor.
    Halai R, Clark RJ, Nevin ST, Jensen JE, Adams DJ, Craik DJ.
    J Biol Chem; 2009 Jul 24; 284(30):20275-84. PubMed ID: 19447885
    [Abstract] [Full Text] [Related]

  • 17. Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor.
    Dutertre S, Nicke A, Lewis RJ.
    J Biol Chem; 2005 Aug 26; 280(34):30460-8. PubMed ID: 15929983
    [Abstract] [Full Text] [Related]

  • 18. Basic Residues at Position 11 of α-Conotoxin LvIA Influence Subtype Selectivity between α3β2 and α3β4 Nicotinic Receptors via an Electrostatic Mechanism.
    Haufe Y, Kuruva V, Samanani Z, Lokaj G, Kamnesky G, Shadamarshan P, Shahoei R, Katz D, Sampson JM, Pusch M, Brik A, Nicke A, Leffler AE.
    ACS Chem Neurosci; 2023 Dec 20; 14(24):4311-4322. PubMed ID: 38051211
    [Abstract] [Full Text] [Related]

  • 19. Potency- and Selectivity-Enhancing Mutations of Conotoxins for Nicotinic Acetylcholine Receptors Can Be Predicted Using Accurate Free-Energy Calculations.
    Katz D, DiMattia MA, Sindhikara D, Li H, Abraham N, Leffler AE.
    Mar Drugs; 2021 Jun 25; 19(7):. PubMed ID: 34202022
    [Abstract] [Full Text] [Related]

  • 20. Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor.
    Abraham N, Healy M, Ragnarsson L, Brust A, Alewood PF, Lewis RJ.
    Sci Rep; 2017 Mar 31; 7():45466. PubMed ID: 28361878
    [Abstract] [Full Text] [Related]

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