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Journal Abstract Search

233 related items for PubMed ID: 27703006

  • 1. Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation.
    Mitra S, Ghosh B, Gayen N, Roy J, Mandal AK.
    J Biol Chem; 2016 Nov 18; 291(47):24579-24593. PubMed ID: 27703006
    [Abstract] [Full Text] [Related]

  • 2. Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins.
    Smith JR, de Billy E, Hobbs S, Powers M, Prodromou C, Pearl L, Clarke PA, Workman P.
    Oncogene; 2015 Jan 02; 34(1):15-26. PubMed ID: 24292678
    [Abstract] [Full Text] [Related]

  • 3. p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function.
    Grammatikakis N, Lin JH, Grammatikakis A, Tsichlis PN, Cochran BH.
    Mol Cell Biol; 1999 Mar 02; 19(3):1661-72. PubMed ID: 10022854
    [Abstract] [Full Text] [Related]

  • 4. Analyses of the oncogenic BRAFD594G variant reveal a kinase-independent function of BRAF in activating MAPK signaling.
    Cope NJ, Novak B, Liu Z, Cavallo M, Gunderwala AY, Connolly M, Wang Z.
    J Biol Chem; 2020 Feb 21; 295(8):2407-2420. PubMed ID: 31929109
    [Abstract] [Full Text] [Related]

  • 5.
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  • 6. HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
    Oberoi J, Guiu XA, Outwin EA, Schellenberger P, Roumeliotis TI, Choudhary JS, Pearl LH.
    Nat Commun; 2022 Nov 29; 13(1):7343. PubMed ID: 36446791
    [Abstract] [Full Text] [Related]

  • 7. Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.
    Zhang BH, Guan KL.
    EMBO J; 2000 Oct 16; 19(20):5429-39. PubMed ID: 11032810
    [Abstract] [Full Text] [Related]

  • 8. Regulation of RAF family kinases: new insights from recent structural and biochemical studies.
    Spencer-Smith R, Morrison DK.
    Biochem Soc Trans; 2024 Jun 26; 52(3):1061-1069. PubMed ID: 38695730
    [Abstract] [Full Text] [Related]

  • 9. Hsp90 provides a platform for kinase dephosphorylation by PP5.
    Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA.
    Nat Commun; 2023 Apr 17; 14(1):2197. PubMed ID: 37069154
    [Abstract] [Full Text] [Related]

  • 10. The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase.
    Stancato LF, Silverstein AM, Owens-Grillo JK, Chow YH, Jove R, Pratt WB.
    J Biol Chem; 1997 Feb 14; 272(7):4013-20. PubMed ID: 9020108
    [Abstract] [Full Text] [Related]

  • 11. ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers.
    Rebocho AP, Marais R.
    Oncogene; 2013 Jun 27; 32(26):3207-12. PubMed ID: 22926515
    [Abstract] [Full Text] [Related]

  • 12. The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho-Ser-621 in the C terminus of CRAF.
    Yuan J, Ng WH, Yap J, Chia B, Huang X, Wang M, Hu J.
    J Biol Chem; 2018 Sep 14; 293(37):14276-14284. PubMed ID: 30030377
    [Abstract] [Full Text] [Related]

  • 13. Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors.
    Chatelle CV, Hövermann D, Müller A, Wagner HJ, Weber W, Radziwill G.
    Sci Rep; 2016 Mar 30; 6():23713. PubMed ID: 27025703
    [Abstract] [Full Text] [Related]

  • 14. The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation.
    Grammatikakis N, Vultur A, Ramana CV, Siganou A, Schweinfest CW, Watson DK, Raptis L.
    J Biol Chem; 2002 Mar 08; 277(10):8312-20. PubMed ID: 11751906
    [Abstract] [Full Text] [Related]

  • 15. Thr90 phosphorylation of Hsp90α by protein kinase A regulates its chaperone machinery.
    Wang X, Lu XA, Song X, Zhuo W, Jia L, Jiang Y, Luo Y.
    Biochem J; 2012 Jan 01; 441(1):387-97. PubMed ID: 21919888
    [Abstract] [Full Text] [Related]

  • 16. c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells.
    Dunn DM, Woodford MR, Truman AW, Jensen SM, Schulman J, Caza T, Remillard TC, Loiselle D, Wolfgeher D, Blagg BS, Franco L, Haystead TA, Daturpalli S, Mayer MP, Trepel JB, Morgan RM, Prodromou C, Kron SJ, Panaretou B, Stetler-Stevenson WG, Landas SK, Neckers L, Bratslavsky G, Bourboulia D, Mollapour M.
    Cell Rep; 2015 Aug 11; 12(6):1006-18. PubMed ID: 26235616
    [Abstract] [Full Text] [Related]

  • 17. Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.
    Vaughan CK, Mollapour M, Smith JR, Truman A, Hu B, Good VM, Panaretou B, Neckers L, Clarke PA, Workman P, Piper PW, Prodromou C, Pearl LH.
    Mol Cell; 2008 Sep 26; 31(6):886-95. PubMed ID: 18922470
    [Abstract] [Full Text] [Related]

  • 18. Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration.
    Mooz J, Oberoi-Khanuja TK, Harms GS, Wang W, Jaiswal BS, Seshagiri S, Tikkanen R, Rajalingam K.
    Sci Signal; 2014 Aug 05; 7(337):ra73. PubMed ID: 25097033
    [Abstract] [Full Text] [Related]

  • 19. Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures.
    Lenz G, Gonçalves D, Luo Z, Avruch J, Rodnight R, Neary JT.
    J Neurochem; 2001 May 05; 77(4):1001-9. PubMed ID: 11359865
    [Abstract] [Full Text] [Related]

  • 20. Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling.
    Kiel C, Serrano L.
    Sci Signal; 2009 Jul 28; 2(81):ra38. PubMed ID: 19638615
    [Abstract] [Full Text] [Related]

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