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Journal Abstract Search

281 related items for PubMed ID: 27709883

  • 1. A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.
    Surmiak E, Twarda-Clapa A, Zak KM, Musielak B, Tomala MD, Kubica K, Grudnik P, Madej M, Jablonski M, Potempa J, Kalinowska-Tluscik J, Dömling A, Dubin G, Holak TA.
    ACS Chem Biol; 2016 Dec 16; 11(12):3310-3318. PubMed ID: 27709883
    [Abstract] [Full Text] [Related]

  • 2. 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.
    Twarda-Clapa A, Krzanik S, Kubica K, Guzik K, Labuzek B, Neochoritis CG, Khoury K, Kowalska K, Czub M, Dubin G, Dömling A, Skalniak L, Holak TA.
    J Med Chem; 2017 May 25; 60(10):4234-4244. PubMed ID: 28482147
    [Abstract] [Full Text] [Related]

  • 3. Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode.
    Gessier F, Kallen J, Jacoby E, Chène P, Stachyra-Valat T, Ruetz S, Jeay S, Holzer P, Masuya K, Furet P.
    Bioorg Med Chem Lett; 2015 Sep 01; 25(17):3621-5. PubMed ID: 26141769
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  • 4. Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.
    Lemos A, Leão M, Soares J, Palmeira A, Pinto M, Saraiva L, Sousa ME.
    Med Res Rev; 2016 Sep 01; 36(5):789-844. PubMed ID: 27302609
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  • 5. Inhibitors of MDM2 and MDMX: a structural perspective.
    Riedinger C, McDonnell JM.
    Future Med Chem; 2009 Sep 01; 1(6):1075-94. PubMed ID: 21425995
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  • 6. Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.
    Li C, Pazgier M, Li C, Yuan W, Liu M, Wei G, Lu WY, Lu W.
    J Mol Biol; 2010 Apr 30; 398(2):200-13. PubMed ID: 20226197
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  • 7. Molecular basis for the inhibition of p53 by Mdmx.
    Popowicz GM, Czarna A, Rothweiler U, Szwagierczak A, Krajewski M, Weber L, Holak TA.
    Cell Cycle; 2007 Oct 01; 6(19):2386-92. PubMed ID: 17938582
    [Abstract] [Full Text] [Related]

  • 8. Small-molecule MDM2-p53 inhibitors: recent advances.
    Zhang B, Golding BT, Hardcastle IR.
    Future Med Chem; 2015 Oct 01; 7(5):631-45. PubMed ID: 25921402
    [Abstract] [Full Text] [Related]

  • 9. An integrated in silico screening strategy for identifying promising disruptors of p53-MDM2 interaction.
    Sirous H, Chemi G, Campiani G, Brogi S.
    Comput Biol Chem; 2019 Dec 01; 83():107105. PubMed ID: 31473433
    [Abstract] [Full Text] [Related]

  • 10. Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidic inhibitors.
    Noguchi T, Oishi S, Honda K, Kondoh Y, Saito T, Kubo T, Kaneda M, Ohno H, Osada H, Fujii N.
    Bioorg Med Chem Lett; 2013 Jul 01; 23(13):3802-5. PubMed ID: 23726030
    [Abstract] [Full Text] [Related]

  • 11. Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
    Grace CR, Ban D, Min J, Mayasundari A, Min L, Finch KE, Griffiths L, Bharatham N, Bashford D, Kiplin Guy R, Dyer MA, Kriwacki RW.
    J Mol Biol; 2016 Mar 27; 428(6):1290-1303. PubMed ID: 26812210
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  • 14. Efficient reactivation of p53 in cancer cells by a dual MdmX/Mdm2 inhibitor.
    Qin L, Yang F, Zhou C, Chen Y, Zhang H, Su Z.
    J Am Chem Soc; 2014 Dec 31; 136(52):18023-33. PubMed ID: 25453499
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  • 17. Discovery of novel dual inhibitors against Mdm2 and Mdmx proteins by in silico approaches and binding assay.
    Golestanian S, Sharifi A, Popowicz GM, Azizian H, Foroumadi A, Szwagierczak A, Holak TA, Amanlou M.
    Life Sci; 2016 Jan 15; 145():240-6. PubMed ID: 26746660
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  • 20. Discovery of novel dihydroimidazothiazole derivatives as p53-MDM2 protein-protein interaction inhibitors: synthesis, biological evaluation and structure-activity relationships.
    Miyazaki M, Kawato H, Naito H, Ikeda M, Miyazaki M, Kitagawa M, Seki T, Fukutake S, Aonuma M, Soga T.
    Bioorg Med Chem Lett; 2012 Oct 15; 22(20):6338-42. PubMed ID: 22995624
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