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Journal Abstract Search

235 related items for PubMed ID: 27714209

  • 1. Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity.
    Maiti M, Gao LJ, Huang C, Ptak RG, Murray MG, De Jonghe S, Herdewijn P.
    Org Biomol Chem; 2016 Sep 21; 14(37):8743-8757. PubMed ID: 27714209
    [Abstract] [Full Text] [Related]

  • 2. Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication.
    Maiti M, Maiti M, Rozenski J, De Jonghe S, Herdewijn P.
    Org Biomol Chem; 2015 May 14; 13(18):5158-74. PubMed ID: 25849139
    [Abstract] [Full Text] [Related]

  • 3. Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.
    Kirschberg TA, Mish MR, Zhang L, Squires NH, Wang KY, Cho A, Feng JY, Fenaux M, Babusis D, Park Y, Ray AS, Kim CU.
    Bioorg Med Chem Lett; 2015 Mar 01; 25(5):1040-3. PubMed ID: 25650256
    [Abstract] [Full Text] [Related]

  • 4. Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection.
    Gardelli C, Attenni B, Donghi M, Meppen M, Pacini B, Harper S, Di Marco A, Fiore F, Giuliano C, Pucci V, Laufer R, Gennari N, Marcucci I, Leone JF, Olsen DB, MacCoss M, Rowley M, Narjes F.
    J Med Chem; 2009 Sep 10; 52(17):5394-407. PubMed ID: 19725579
    [Abstract] [Full Text] [Related]

  • 5. Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.
    McGuigan C, Madela K, Aljarah M, Gilles A, Battina SK, Ramamurty CV, Srinivas Rao C, Vernachio J, Hutchins J, Hall A, Kolykhalov A, Henson G, Chamberlain S.
    Bioorg Med Chem Lett; 2011 Oct 01; 21(19):6007-12. PubMed ID: 21856153
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus.
    Chris Krueger A, Chen HJ, Randolph JT, Brown BS, Halvorsen GT, Heyman HR, Li T, Marvin CC, Shanley JP, Voight EA, Bow DAJ, Van Handel C, Peterkin V, Carr RA, Stolarik D, Dekhtyar T, Irvin ML, Krishnan P, Henry RF, Wagner R, DeGoey DA.
    Bioorg Med Chem; 2020 Jan 01; 28(1):115208. PubMed ID: 31740203
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and anti-HCV activity of a series of β-d-2'-deoxy-2'-dibromo nucleosides and their corresponding phosphoramidate prodrugs.
    Chen Z, Cox BD, Garnier-Amblard EC, McBrayer TR, Coats SJ, Schinazi RF, Amblard F.
    Bioorg Med Chem Lett; 2017 Dec 01; 27(23):5296-5299. PubMed ID: 29066308
    [Abstract] [Full Text] [Related]

  • 8. Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.
    Rondla R, Coats SJ, McBrayer TR, Grier J, Johns M, Tharnish PM, Whitaker T, Zhou L, Schinazi RF.
    Antivir Chem Chemother; 2009 Oct 19; 20(2):99-106. PubMed ID: 19843980
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.
    Wang G, Dyatkina N, Prhavc M, Williams C, Serebryany V, Hu Y, Huang Y, Wan J, Wu X, Deval J, Fung A, Jin Z, Tan H, Shaw K, Kang H, Zhang Q, Tam Y, Stoycheva A, Jekle A, Smith DB, Beigelman L.
    J Med Chem; 2019 May 09; 62(9):4555-4570. PubMed ID: 30951311
    [Abstract] [Full Text] [Related]

  • 10. Discovery of β-d-2'-deoxy-2'-dichlorouridine nucleotide prodrugs as potent inhibitors of hepatitis C virus replication.
    Pinho P, Kalayanov G, Westerlind H, Rosenquist Å, Wähling H, Sund C, Almeida M, Ayesa S, Tejbrant J, Targett-Adams P, Eneroth A, Lindqvist A.
    Bioorg Med Chem Lett; 2017 Aug 01; 27(15):3468-3471. PubMed ID: 28622881
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.
    Cho JH, Bondana L, Detorio MA, Montero C, Bassit LC, Amblard F, Coats SJ, Schinazi RF.
    Bioorg Med Chem; 2014 Dec 01; 22(23):6665-6671. PubMed ID: 25458500
    [Abstract] [Full Text] [Related]

  • 12. Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.
    McGuigan C, Gilles A, Madela K, Aljarah M, Holl S, Jones S, Vernachio J, Hutchins J, Ames B, Bryant KD, Gorovits E, Ganguly B, Hunley D, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters R, Wang J, Chamberlain S, Henson G.
    J Med Chem; 2010 Jul 08; 53(13):4949-57. PubMed ID: 20527890
    [Abstract] [Full Text] [Related]

  • 13. β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.
    Zhou L, Zhang HW, Tao S, Bassit L, Whitaker T, McBrayer TR, Ehteshami M, Amiralaei S, Pradere U, Cho JH, Amblard F, Bobeck D, Detorio M, Coats SJ, Schinazi RF.
    J Med Chem; 2015 Apr 23; 58(8):3445-58. PubMed ID: 25849312
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates.
    Shi J, Zhou L, Zhang H, McBrayer TR, Detorio MA, Johns M, Bassit L, Powdrill MH, Whitaker T, Coats SJ, Götte M, Schinazi RF.
    Bioorg Med Chem Lett; 2011 Dec 01; 21(23):7094-8. PubMed ID: 22014549
    [Abstract] [Full Text] [Related]

  • 15. Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
    Kirschberg TA, Metobo S, Clarke MO, Aktoudianakis V, Babusis D, Barauskas O, Birkus G, Butler T, Byun D, Chin G, Doerffler E, Edwards TE, Fenaux M, Lee R, Lew W, Mish MR, Murakami E, Park Y, Squires NH, Tirunagari N, Wang T, Whitcomb M, Xu J, Yang H, Ye H, Zhang L, Appleby TC, Feng JY, Ray AS, Cho A, Kim CU.
    Bioorg Med Chem Lett; 2017 Apr 15; 27(8):1840-1847. PubMed ID: 28274633
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and anti-herpetic activity of phosphoramidate ProTides.
    Maiti M, Persoons L, Andrei G, Snoeck R, Balzarini J, Herdewijn P.
    ChemMedChem; 2013 Jun 15; 8(6):985-93. PubMed ID: 23606629
    [Abstract] [Full Text] [Related]

  • 17. Evaluation of novel phosphoramidate ProTides of the 2'-fluoro derivatives of a potent anti-varicella zoster virus bicyclic nucleoside analogue.
    Derudas M, Quintiliani M, Brancale A, Andrei G, Snoeck R, Balzarini J, McGuigan C.
    Antivir Chem Chemother; 2010 Oct 28; 21(1):15-31. PubMed ID: 21045257
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and biological evaluation of a novel β-D-2'-deoxy-2'-α-fluoro-2'-β-C-(fluoromethyl)uridine phosphoramidate prodrug for the treatment of hepatitis C virus infection.
    Li E, Wang Y, Yu W, Lv Z, Peng Y, Liu B, Li S, Ho W, Wang Q, Li H, Chang J.
    Eur J Med Chem; 2018 Jan 01; 143():107-113. PubMed ID: 29172078
    [Abstract] [Full Text] [Related]

  • 19. Phosphoramidate prodrugs deliver with potency against hepatitis C virus.
    Mehellou Y.
    ChemMedChem; 2010 Nov 08; 5(11):1841-2. PubMed ID: 20865770
    [No Abstract] [Full Text] [Related]

  • 20. Intracellular metabolism and potential cardiotoxicity of a β-D-2'-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication.
    Tao S, Zhou L, Zhang H, Zhou S, Amiralaei S, Shelton J, Ehteshami M, Jiang Y, Amblard F, Coats SJ, Schinazi RF.
    Nucleosides Nucleotides Nucleic Acids; 2020 Nov 08; 39(1-3):204-224. PubMed ID: 31595843
    [Abstract] [Full Text] [Related]

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