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Journal Abstract Search

565 related items for PubMed ID: 27744252

  • 1. Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.
    Joubert J, Foka GB, Repsold BP, Oliver DW, Kapp E, Malan SF.
    Eur J Med Chem; 2017 Jan 05; 125():853-864. PubMed ID: 27744252
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.
    Lan JS, Ding Y, Liu Y, Kang P, Hou JW, Zhang XY, Xie SS, Zhang T.
    Eur J Med Chem; 2017 Oct 20; 139():48-59. PubMed ID: 28797883
    [Abstract] [Full Text] [Related]

  • 3. Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.
    Xie SS, Lan JS, Wang X, Wang ZM, Jiang N, Li F, Wu JJ, Wang J, Kong LY.
    Bioorg Med Chem; 2016 Apr 01; 24(7):1528-39. PubMed ID: 26917219
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
    Bautista-Aguilera OM, Esteban G, Bolea I, Nikolic K, Agbaba D, Moraleda I, Iriepa I, Samadi A, Soriano E, Unzeta M, Marco-Contelles J.
    Eur J Med Chem; 2014 Mar 21; 75():82-95. PubMed ID: 24530494
    [Abstract] [Full Text] [Related]

  • 5. Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
    Bolea I, Juárez-Jiménez J, de Los Ríos C, Chioua M, Pouplana R, Luque FJ, Unzeta M, Marco-Contelles J, Samadi A.
    J Med Chem; 2011 Dec 22; 54(24):8251-70. PubMed ID: 22023459
    [Abstract] [Full Text] [Related]

  • 6. Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.
    Bautista-Aguilera OM, Esteban G, Chioua M, Nikolic K, Agbaba D, Moraleda I, Iriepa I, Soriano E, Samadi A, Unzeta M, Marco-Contelles J.
    Drug Des Devel Ther; 2014 Dec 22; 8():1893-910. PubMed ID: 25378907
    [Abstract] [Full Text] [Related]

  • 7. Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
    Xie SS, Wang X, Jiang N, Yu W, Wang KD, Lan JS, Li ZR, Kong LY.
    Eur J Med Chem; 2015 May 05; 95():153-65. PubMed ID: 25812965
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer's disease.
    Li F, Wang ZM, Wu JJ, Wang J, Xie SS, Lan JS, Xu W, Kong LY, Wang XB.
    J Enzyme Inhib Med Chem; 2016 May 05; 31(sup3):41-53. PubMed ID: 27384289
    [Abstract] [Full Text] [Related]

  • 9. Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
    Samadi A, de los Ríos C, Bolea I, Chioua M, Iriepa I, Moraleda I, Bartolini M, Andrisano V, Gálvez E, Valderas C, Unzeta M, Marco-Contelles J.
    Eur J Med Chem; 2012 Jun 05; 52():251-62. PubMed ID: 22503231
    [Abstract] [Full Text] [Related]

  • 10. Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
    Wang L, Esteban G, Ojima M, Bautista-Aguilera OM, Inokuchi T, Moraleda I, Iriepa I, Samadi A, Youdim MB, Romero A, Soriano E, Herrero R, Fernández Fernández AP, Ricardo-Martínez-Murillo, Marco-Contelles J, Unzeta M.
    Eur J Med Chem; 2014 Jun 10; 80():543-61. PubMed ID: 24813882
    [Abstract] [Full Text] [Related]

  • 11. Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.
    Pisani L, Farina R, Catto M, Iacobazzi RM, Nicolotti O, Cellamare S, Mangiatordi GF, Denora N, Soto-Otero R, Siragusa L, Altomare CD, Carotti A.
    J Med Chem; 2016 Jul 28; 59(14):6791-806. PubMed ID: 27347731
    [Abstract] [Full Text] [Related]

  • 12. Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
    Sang Z, Pan W, Wang K, Ma Q, Yu L, Liu W.
    Bioorg Med Chem; 2017 Jun 15; 25(12):3006-3017. PubMed ID: 28487125
    [Abstract] [Full Text] [Related]

  • 13. Coumarin-dithiocarbamate hybrids as novel multitarget AChE and MAO-B inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation.
    He Q, Liu J, Lan JS, Ding J, Sun Y, Fang Y, Jiang N, Yang Z, Sun L, Jin Y, Xie SS.
    Bioorg Chem; 2018 Dec 15; 81():512-528. PubMed ID: 30245233
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size of aryl binding site.
    Tripathi RKP, M Sasi V, Gupta SK, Krishnamurthy S, Ayyannan SR.
    J Enzyme Inhib Med Chem; 2018 Dec 15; 33(1):37-57. PubMed ID: 29098902
    [Abstract] [Full Text] [Related]

  • 15. Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.
    Shaik JB, Palaka BK, Penumala M, Kotapati KV, Devineni SR, Eadlapalli S, Darla MM, Ampasala DR, Vadde R, Amooru GD.
    Eur J Med Chem; 2016 Jan 01; 107():219-32. PubMed ID: 26588065
    [Abstract] [Full Text] [Related]

  • 16. Cyanobiphenyls: Novel H3 receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease.
    Godyń J, Zaręba P, Łażewska D, Stary D, Reiner-Link D, Frank A, Latacz G, Mogilski S, Kaleta M, Doroz-Płonka A, Lubelska A, Honkisz-Orzechowska E, Olejarz-Maciej A, Handzlik J, Stark H, Kieć-Kononowicz K, Malawska B, Bajda M.
    Bioorg Chem; 2021 Sep 01; 114():105129. PubMed ID: 34217977
    [Abstract] [Full Text] [Related]

  • 17. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents.
    Košak U, Strašek N, Knez D, Jukič M, Žakelj S, Zahirović A, Pišlar A, Brazzolotto X, Nachon F, Kos J, Gobec S.
    Eur J Med Chem; 2020 Jul 01; 197():112282. PubMed ID: 32380361
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.
    Xie SS, Wang XB, Li JY, Yang L, Kong LY.
    Eur J Med Chem; 2013 Jun 01; 64():540-53. PubMed ID: 23685572
    [Abstract] [Full Text] [Related]

  • 19. Rational Design and Multibiological Profiling of Novel Donepezil-Trolox Hybrids against Alzheimer's Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties.
    Cai P, Fang SQ, Yang XL, Wu JJ, Liu QH, Hong H, Wang XB, Kong LY.
    ACS Chem Neurosci; 2017 Nov 15; 8(11):2496-2511. PubMed ID: 28806057
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis and evaluation of chalcone Mannich base derivatives as multifunctional agents for the potential treatment of Alzheimer's disease.
    Zhang X, Song Q, Cao Z, Li Y, Tian C, Yang Z, Zhang H, Deng Y.
    Bioorg Chem; 2019 Jun 15; 87():395-408. PubMed ID: 30921741
    [Abstract] [Full Text] [Related]

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