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Journal Abstract Search

184 related items for PubMed ID: 27805821

  • 1. Potent Antitumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin.
    Zhou P, Liu Y, Zhou L, Zhu K, Feng K, Zhang H, Liang Y, Jiang H, Luo C, Liu M, Wang Y.
    J Med Chem; 2016 Nov 23; 59(22):10329-10334. PubMed ID: 27805821
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
    Zhou P, Liang Y, Zhang H, Jiang H, Feng K, Xu P, Wang J, Wang X, Ding K, Luo C, Liu M, Wang Y.
    Eur J Med Chem; 2018 Jan 20; 144():817-842. PubMed ID: 29306206
    [Abstract] [Full Text] [Related]

  • 3. Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.
    Carr M, Greene LM, Knox AJ, Lloyd DG, Zisterer DM, Meegan MJ.
    Eur J Med Chem; 2010 Dec 20; 45(12):5752-66. PubMed ID: 20933304
    [Abstract] [Full Text] [Related]

  • 4. β-Lactams with antiproliferative and antiapoptotic activity in breast and chemoresistant colon cancer cells.
    Malebari AM, Fayne D, Nathwani SM, O'Connell F, Noorani S, Twamley B, O'Boyle NM, O'Sullivan J, Zisterer DM, Meegan MJ.
    Eur J Med Chem; 2020 Mar 01; 189():112050. PubMed ID: 31954879
    [Abstract] [Full Text] [Related]

  • 5. Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.
    Lai Q, Wang Y, Wang R, Lai W, Tang L, Tao Y, Liu Y, Zhang R, Huang L, Xiang H, Zeng S, Gou L, Chen H, Yao Y, Yang J.
    Eur J Med Chem; 2018 Aug 05; 156():162-179. PubMed ID: 30006162
    [Abstract] [Full Text] [Related]

  • 6. Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins.
    Jiménez C, Ellahioui Y, Álvarez R, Aramburu L, Riesco A, González M, Vicente A, Dahdouh A, Ibn Mansour A, Jiménez C, Martín D, Sarmiento RG, Medarde M, Caballero E, Peláez R.
    Eur J Med Chem; 2015 Jul 15; 100():210-22. PubMed ID: 26092446
    [Abstract] [Full Text] [Related]

  • 7. 1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin.
    Odlo K, Hentzen J, dit Chabert JF, Ducki S, Gani OA, Sylte I, Skrede M, Flørenes VA, Hansen TV.
    Bioorg Med Chem; 2008 May 01; 16(9):4829-38. PubMed ID: 18396050
    [Abstract] [Full Text] [Related]

  • 8. Structure-Activity Relationship Studies of β-Lactam-azide Analogues as Orally Active Antitumor Agents Targeting the Tubulin Colchicine Site.
    Fu DJ, Fu L, Liu YC, Wang JW, Wang YQ, Han BK, Li XR, Zhang C, Li F, Song J, Zhao B, Mao RW, Zhao RH, Zhang SY, Zhang L, Zhang YB, Liu HM.
    Sci Rep; 2017 Oct 06; 7(1):12788. PubMed ID: 28986548
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and Biochemical Evaluation of 3-Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents.
    Greene TF, Wang S, Greene LM, Nathwani SM, Pollock JK, Malebari AM, McCabe T, Twamley B, O'Boyle NM, Zisterer DM, Meegan MJ.
    J Med Chem; 2016 Jan 14; 59(1):90-113. PubMed ID: 26680364
    [Abstract] [Full Text] [Related]

  • 10. Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones.
    O'Boyle NM, Greene LM, Bergin O, Fichet JB, McCabe T, Lloyd DG, Zisterer DM, Meegan MJ.
    Bioorg Med Chem; 2011 Apr 01; 19(7):2306-25. PubMed ID: 21397510
    [Abstract] [Full Text] [Related]

  • 11. Novel hybrid nocodazole analogues as tubulin polymerization inhibitors and their antiproliferative activity.
    Kale SS, Jedhe GS, Meshram SN, Santra MK, Hamel E, Sanjayan GJ.
    Bioorg Med Chem Lett; 2015 May 01; 25(9):1982-5. PubMed ID: 25817588
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and biological evaluation of N-substituted 3-oxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxylic acid derivatives as tubulin polymerization inhibitors.
    Qi J, Dong H, Huang J, Zhang S, Niu L, Zhang Y, Wang J.
    Eur J Med Chem; 2018 Jan 01; 143():8-20. PubMed ID: 29172084
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and Biological Evaluations of 1,2-Diaryl Pyrroles as Analogues of Combretastatin A-4.
    Sun J, Chen L, Liu C, Wang Z, Zuo D, Pan J, Qi H, Bao K, Wu Y, Zhang W.
    Chem Biol Drug Des; 2015 Dec 01; 86(6):1541-7. PubMed ID: 26202587
    [Abstract] [Full Text] [Related]

  • 14. Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop.
    Bueno O, Gargantilla M, Estévez-Gallego J, Martins S, Díaz JF, Camarasa MJ, Liekens S, Pérez-Pérez MJ, Priego EM.
    Eur J Med Chem; 2019 Jun 01; 171():195-208. PubMed ID: 30921759
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and biological evaluation of 4,6-diphenyl-2-(1H-pyrrol-1-yl)nicotinonitrile analogues of crolibulin and combretastatin A-4.
    Liu Y, Yang D, Hong Z, Guo S, Liu M, Zuo D, Ge D, Qin M, Sun D.
    Eur J Med Chem; 2018 Feb 25; 146():185-193. PubMed ID: 29407949
    [Abstract] [Full Text] [Related]

  • 16. Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues.
    Mustafa M, Abdelhamid D, Abdelhafez EMN, Ibrahim MAA, Gamal-Eldeen AM, Aly OM.
    Eur J Med Chem; 2017 Dec 01; 141():293-305. PubMed ID: 29031074
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and biological evaluation of pyrimidine bridged combretastatin derivatives as potential anticancer agents and mechanistic studies.
    Kumar B, Sharma P, Gupta VP, Khullar M, Singh S, Dogra N, Kumar V.
    Bioorg Chem; 2018 Aug 01; 78():130-140. PubMed ID: 29554587
    [Abstract] [Full Text] [Related]

  • 18. Discovery of azaisoerianin derivatives as potential antitumors agents.
    Soussi MA, Provot O, Bernadat G, Bignon J, Wdzieczak-Bakala J, Desravines D, Dubois J, Brion JD, Messaoudi S, Alami M.
    Eur J Med Chem; 2014 May 06; 78():178-89. PubMed ID: 24681982
    [Abstract] [Full Text] [Related]

  • 19. Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.
    Liu YN, Wang JJ, Ji YT, Zhao GD, Tang LQ, Zhang CM, Guo XL, Liu ZP.
    J Med Chem; 2016 Jun 09; 59(11):5341-55. PubMed ID: 27172319
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis, and biological evaluation of novel combretastatin A-4 thio derivatives as microtubule targeting agents.
    Stefański T, Mikstacka R, Kurczab R, Dutkiewicz Z, Kucińska M, Murias M, Zielińska-Przyjemska M, Cichocki M, Teubert A, Kaczmarek M, Hogendorf A, Sobiak S.
    Eur J Med Chem; 2018 Jan 20; 144():797-816. PubMed ID: 29291446
    [Abstract] [Full Text] [Related]

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