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391 related items for PubMed ID: 27864845

  • 1. Activity of the anticonvulsant lacosamide in experimental and human epilepsy via selective effects on slow Na+ channel inactivation.
    Holtkamp D, Opitz T, Niespodziany I, Wolff C, Beck H.
    Epilepsia; 2017 Jan; 58(1):27-41. PubMed ID: 27864845
    [Abstract] [Full Text] [Related]

  • 2. Effects of eslicarbazepine on slow inactivation processes of sodium channels in dentate gyrus granule cells.
    Holtkamp D, Opitz T, Hebeisen S, Soares-da-Silva P, Beck H.
    Epilepsia; 2018 Aug; 59(8):1492-1506. PubMed ID: 29953587
    [Abstract] [Full Text] [Related]

  • 3. Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats.
    Remy S, Urban BW, Elger CE, Beck H.
    Eur J Neurosci; 2003 Jun; 17(12):2648-58. PubMed ID: 12823472
    [Abstract] [Full Text] [Related]

  • 4. Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs.
    Pothmann L, Müller C, Averkin RG, Bellistri E, Miklitz C, Uebachs M, Remy S, Menendez de la Prida L, Beck H.
    J Neurosci; 2014 Jul 16; 34(29):9720-35. PubMed ID: 25031410
    [Abstract] [Full Text] [Related]

  • 5. Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+ currents.
    Uebachs M, Albus C, Opitz T, Isom L, Niespodziany I, Wolff C, Beck H.
    Epilepsia; 2012 Nov 16; 53(11):1959-67. PubMed ID: 23016711
    [Abstract] [Full Text] [Related]

  • 6. Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy.
    Schaub C, Uebachs M, Beck H.
    Epilepsia; 2007 Jul 16; 48(7):1339-50. PubMed ID: 17441992
    [Abstract] [Full Text] [Related]

  • 7. Seeking a mechanism of action for the novel anticonvulsant lacosamide.
    Errington AC, Coyne L, Stöhr T, Selve N, Lees G.
    Neuropharmacology; 2006 Jun 16; 50(8):1016-29. PubMed ID: 16620882
    [Abstract] [Full Text] [Related]

  • 8. Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide.
    Hebeisen S, Pires N, Loureiro AI, Bonifácio MJ, Palma N, Whyment A, Spanswick D, Soares-da-Silva P.
    Neuropharmacology; 2015 Feb 16; 89():122-35. PubMed ID: 25242737
    [Abstract] [Full Text] [Related]

  • 9. Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug.
    Doeser A, Dickhof G, Reitze M, Uebachs M, Schaub C, Pires NM, Bonifácio MJ, Soares-da-Silva P, Beck H.
    Brain; 2015 Feb 16; 138(Pt 2):371-87. PubMed ID: 25472797
    [Abstract] [Full Text] [Related]

  • 10. Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders.
    Curia G, Biagini G, Perucca E, Avoli M.
    CNS Drugs; 2009 Feb 16; 23(7):555-68. PubMed ID: 19552484
    [Abstract] [Full Text] [Related]

  • 11. Polyamine Modulation of Anticonvulsant Drug Response: A Potential Mechanism Contributing to Pharmacoresistance in Chronic Epilepsy.
    Beckonert NM, Opitz T, Pitsch J, Soares da Silva P, Beck H.
    J Neurosci; 2018 Jun 13; 38(24):5596-5605. PubMed ID: 29789377
    [Abstract] [Full Text] [Related]

  • 12. Comparative study of lacosamide and classical sodium channel blocking antiepileptic drugs on sodium channel slow inactivation.
    Niespodziany I, Leclère N, Vandenplas C, Foerch P, Wolff C.
    J Neurosci Res; 2013 Mar 13; 91(3):436-43. PubMed ID: 23239147
    [Abstract] [Full Text] [Related]

  • 13. The anticonvulsant SGB-017 (ADCI) blocks voltage-gated sodium channels in rat and human neurons: comparison with carbamazepine.
    Sun L, Lin SS.
    Epilepsia; 2000 Mar 13; 41(3):263-70. PubMed ID: 10714396
    [Abstract] [Full Text] [Related]

  • 14. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels.
    Errington AC, Stöhr T, Heers C, Lees G.
    Mol Pharmacol; 2008 Jan 13; 73(1):157-69. PubMed ID: 17940193
    [Abstract] [Full Text] [Related]

  • 15. Effects of lacosamide and carbamazepine on human motor cortex excitability: a double-blind, placebo-controlled transcranial magnetic stimulation study.
    Lang N, Rothkegel H, Peckolt H, Deuschl G.
    Seizure; 2013 Nov 13; 22(9):726-30. PubMed ID: 23778157
    [Abstract] [Full Text] [Related]

  • 16. V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels.
    Ilyin VI, Hodges DD, Whittemore ER, Carter RB, Cai SX, Woodward RM.
    Br J Pharmacol; 2005 Mar 13; 144(6):801-12. PubMed ID: 15778702
    [Abstract] [Full Text] [Related]

  • 17. In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation.
    Wang Y, Brittain JM, Jarecki BW, Park KD, Wilson SM, Wang B, Hale R, Meroueh SO, Cummins TR, Khanna R.
    J Biol Chem; 2010 Aug 13; 285(33):25296-307. PubMed ID: 20538611
    [Abstract] [Full Text] [Related]

  • 18. Current understanding of the mechanism of action of the antiepileptic drug lacosamide.
    Rogawski MA, Tofighy A, White HS, Matagne A, Wolff C.
    Epilepsy Res; 2015 Feb 13; 110():189-205. PubMed ID: 25616473
    [Abstract] [Full Text] [Related]

  • 19. Modulation of sodium channel inactivation gating by a novel lactam: implications for seizure suppression in chronic limbic epilepsy.
    Jones PJ, Merrick EC, Batts TW, Hargus NJ, Wang Y, Stables JP, Bertram EH, Brown ML, Patel MK.
    J Pharmacol Exp Ther; 2009 Jan 13; 328(1):201-12. PubMed ID: 18952887
    [Abstract] [Full Text] [Related]

  • 20. Effect of phenytoin on sodium and calcium currents in hippocampal CA1 neurons of phenytoin-resistant kindled rats.
    Jeub M, Beck H, Siep E, Rüschenschmidt C, Speckmann EJ, Ebert U, Potschka H, Freichel C, Reissmüller E, Löscher W.
    Neuropharmacology; 2002 Jan 13; 42(1):107-16. PubMed ID: 11750920
    [Abstract] [Full Text] [Related]

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