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317 related items for PubMed ID: 2786565

  • 1. Structure-activity study of the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. II. Evaluation of the biological activity of the pyridinium metabolites formed from the monoamine oxidase-catalyzed oxidation of MPTP analogs.
    Youngster SK, Nicklas WJ, Heikkila RE.
    J Pharmacol Exp Ther; 1989 Jun; 249(3):829-35. PubMed ID: 2786565
    [Abstract] [Full Text] [Related]

  • 2. Structure-activity study of the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. I. Evaluation of the biological activity of MPTP analogs.
    Youngster SK, Sonsalla PK, Sieber BA, Heikkila RE.
    J Pharmacol Exp Ther; 1989 Jun; 249(3):820-8. PubMed ID: 2786564
    [Abstract] [Full Text] [Related]

  • 3. Characteristics of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the mouse.
    Sonsalla PK, Youngster SK, Kindt MV, Heikkila RE.
    J Pharmacol Exp Ther; 1987 Sep; 242(3):850-7. PubMed ID: 2888874
    [Abstract] [Full Text] [Related]

  • 4. Depletion of heart norepinephrine in mice by some analogs of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).
    Fuller RW, Hemrick-Luecke SK.
    Res Commun Chem Pathol Pharmacol; 1987 May; 56(2):147-56. PubMed ID: 3496637
    [Abstract] [Full Text] [Related]

  • 5. Mitochondrial and metabolic toxicity of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine.
    Kindt MV, Heikkila RE, Nicklas WJ.
    J Pharmacol Exp Ther; 1987 Sep; 242(3):858-63. PubMed ID: 3498818
    [Abstract] [Full Text] [Related]

  • 6. Correlation between the neostriatal content of the 1-methyl-4-phenylpyridinium species and dopaminergic neurotoxicity following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to several strains of mice.
    Giovanni A, Sieber BA, Heikkila RE, Sonsalla PK.
    J Pharmacol Exp Ther; 1991 May; 257(2):691-7. PubMed ID: 2033514
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  • 9. Neurotoxicity studies with the monoamine oxidase B substrate 1-methyl-3-phenyl-3-pyrroline.
    Ogunrombi MO, Malan SF, Terre'Blanche G, Castagnoli K, Castagnoli N, Bergh JJ, Petzer JP.
    Life Sci; 2007 Jul 19; 81(6):458-67. PubMed ID: 17655878
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  • 10. 1-methyl-4-phenylpyridine is neurotoxic to the nigrostriatal dopamine pathway.
    Bradbury AJ, Costall B, Domeney AM, Jenner P, Kelly ME, Marsden CD, Naylor RJ.
    Nature; 2007 Jul 19; 319(6048):56-7. PubMed ID: 3484542
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  • 11. Attenuation by dopamine uptake blockers of the inhibitory effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and some of its analogs on NADH-linked metabolism in mouse neostriatal slices.
    Ofori S, Heikkila RE, Nicklas WJ.
    J Pharmacol Exp Ther; 1989 Oct 19; 251(1):258-66. PubMed ID: 2571719
    [Abstract] [Full Text] [Related]

  • 12. A reactive metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is formed in rat brain in vitro by type B monoamine oxidase.
    Corsini GU, Pintus S, Bocchetta A, Piccardi MP, Del Zompo M.
    J Pharmacol Exp Ther; 1986 Aug 19; 238(2):648-52. PubMed ID: 3488394
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  • 13. Development of fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs with potent nigrostriatal toxicity for potential use in positron emission tomography studies.
    Harik SI, Riachi NJ, Hritz MA, Berridge MS, Sayre LM.
    J Pharmacol Exp Ther; 1993 Aug 19; 266(2):790-5. PubMed ID: 8355208
    [Abstract] [Full Text] [Related]

  • 14. Evaluation of the biological activity of several analogs of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
    Youngster SK, Sonsalla PK, Heikkila RE.
    J Neurochem; 1987 Mar 19; 48(3):929-34. PubMed ID: 3492590
    [Abstract] [Full Text] [Related]

  • 15. On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: the effect of perinigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, its metabolite and their analogs in the rat.
    Harik SI, Schmidley JW, Iacofano LA, Blue P, Arora PK, Sayre LM.
    J Pharmacol Exp Ther; 1987 May 19; 241(2):669-76. PubMed ID: 2437293
    [Abstract] [Full Text] [Related]

  • 16. Comparison of the effects of two 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs, 1-methyl-4-(2-thienyl)-1,2,3,6-tetrahydropyridine and 1-methyl-4-(3-thienyl)-1,2,3,6-tetrahydropyridine, on monoamine oxidase in vitro and on dopamine in mouse brain.
    Fuller RW, Robertson DW, Hemrick-Luecke SK.
    J Pharmacol Exp Ther; 1987 Feb 19; 240(2):415-20. PubMed ID: 3100775
    [Abstract] [Full Text] [Related]

  • 17. The role of MAO in MPTP toxicity--a review.
    Glover V, Gibb C, Sandler M.
    J Neural Transm Suppl; 1986 Feb 19; 20():65-76. PubMed ID: 3091762
    [Abstract] [Full Text] [Related]

  • 18. Age-dependent effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): correlation with monoamine oxidase-B.
    Walsh SL, Wagner GC.
    Synapse; 1989 Feb 19; 3(4):308-14. PubMed ID: 2787063
    [Abstract] [Full Text] [Related]

  • 19. Importance of monoamine oxidase A in the bioactivation of neurotoxic analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
    Heikkila RE, Kindt MV, Sonsalla PK, Giovanni A, Youngster SK, McKeown KA, Singer TP.
    Proc Natl Acad Sci U S A; 1988 Aug 19; 85(16):6172-6. PubMed ID: 3137566
    [Abstract] [Full Text] [Related]

  • 20. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells: role of monoamine oxidase A.
    Basma AN, Heikkila RE, Nicklas WJ, Giovanni A, Geller HM.
    J Neurochem; 1990 Sep 19; 55(3):870-7. PubMed ID: 2384758
    [Abstract] [Full Text] [Related]

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