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157 related items for PubMed ID: 27989137

  • 1. Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines.
    Carlson ES, Upadhyaya P, Hecht SS.
    Chem Res Toxicol; 2016 Dec 19; 29(12):2194-2205. PubMed ID: 27989137
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  • 3. Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.
    Jalas JR, Ding X, Murphy SE.
    Drug Metab Dispos; 2003 Oct 19; 31(10):1199-202. PubMed ID: 12975327
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  • 5. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate.
    Smith TJ, Guo Z, Guengerich FP, Yang CS.
    Carcinogenesis; 1996 Apr 19; 17(4):809-13. PubMed ID: 8625495
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  • 7. Stereoselective metabolism of nicotine and tobacco-specific N-nitrosamines to 4-hydroxy-4-(3-pyridyl)butanoic acid in rats.
    Trushin N, Hecht SS.
    Chem Res Toxicol; 1999 Feb 19; 12(2):164-71. PubMed ID: 10027794
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  • 8. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.
    Patten CJ, Smith TJ, Murphy SE, Wang MH, Lee J, Tynes RE, Koch P, Yang CS.
    Arch Biochem Biophys; 1996 Sep 01; 333(1):127-38. PubMed ID: 8806763
    [Abstract] [Full Text] [Related]

  • 9. Evidence for metabolic activation of N'-nitrosonornicotine and N-nitrosobenzylmethylamine by a rat nasal coumarin hydroxylase.
    Patten CJ, Peterson LA, Murphy SE.
    Drug Metab Dispos; 1998 Feb 01; 26(2):177-80. PubMed ID: 9456305
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  • 10. Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes.
    Wong HL, Zhang X, Zhang QY, Gu J, Ding X, Hecht SS, Murphy SE.
    Chem Res Toxicol; 2005 Jun 01; 18(6):913-8. PubMed ID: 15962925
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  • 11. Cell specificity for the pulmonary metabolism of tobacco-specific nitrosamines in the Fischer rat.
    Belinsky SA, White CM, Trushin N, Hecht SS.
    Carcinogenesis; 1989 Dec 01; 10(12):2269-74. PubMed ID: 2591016
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  • 12. Formation of hemoglobin adducts upon treatment of F344 rats with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.
    Carmella SG, Hecht SS.
    Cancer Res; 1987 May 15; 47(10):2626-30. PubMed ID: 3567895
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  • 13. Molecular Basis for Metabolic Regioselectivity and Mechanism of Cytochrome P450s toward Carcinogenic 4-(Methylnitrosamino)-(3-pyridyl)-1-butanone.
    Ma G, Yu H, Xu X, Geng L, Wei X, Wen J, Wang Z.
    Chem Res Toxicol; 2020 Feb 17; 33(2):436-447. PubMed ID: 31889441
    [Abstract] [Full Text] [Related]

  • 14. Investigation of 2'-Deoxyadenosine-Derived Adducts Specifically Formed in Rat Liver and Lung DNA by N'-Nitrosonornicotine Metabolism.
    Li Y, Carlson ES, Zarth AT, Upadhyaya P, Hecht SS.
    Chem Res Toxicol; 2021 Apr 19; 34(4):1004-1015. PubMed ID: 33720703
    [Abstract] [Full Text] [Related]

  • 15. Insight into the Interaction Mechanism of Nicotine, NNK, and NNN with Cytochrome P450 2A13 Based on Molecular Dynamics Simulation.
    Neves Cruz J, Santana de Oliveira M, Gomes Silva S, Pedro da Silva Souza Filho A, Santiago Pereira D, Lima E Lima AH, de Aguiar Andrade EH.
    J Chem Inf Model; 2020 Feb 24; 60(2):766-776. PubMed ID: 31622091
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  • 16. Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Upadhyaya P, Kalscheuer S, Hochalter JB, Villalta PW, Hecht SS.
    Chem Res Toxicol; 2008 Jul 24; 21(7):1468-76. PubMed ID: 18570389
    [Abstract] [Full Text] [Related]

  • 17. Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes.
    Yamazaki H, Inui Y, Yun CH, Guengerich FP, Shimada T.
    Carcinogenesis; 1992 Oct 24; 13(10):1789-94. PubMed ID: 1423839
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  • 18. Identification of an N'-Nitrosonornicotine-Specific Deoxyadenosine Adduct in Rat Liver and Lung DNA.
    Li Y, Hecht SS.
    Chem Res Toxicol; 2021 Apr 19; 34(4):992-1003. PubMed ID: 33705110
    [Abstract] [Full Text] [Related]

  • 19. Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines.
    Hecht SS, Stepanov I, Carmella SG.
    Acc Chem Res; 2016 Jan 19; 49(1):106-14. PubMed ID: 26678241
    [Abstract] [Full Text] [Related]

  • 20. Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes.
    Staretz ME, Murphy SE, Patten CJ, Nunes MG, Koehl W, Amin S, Koenig LA, Guengerich FP, Hecht SS.
    Drug Metab Dispos; 1997 Feb 19; 25(2):154-62. PubMed ID: 9029045
    [Abstract] [Full Text] [Related]

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