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Journal Abstract Search

211 related items for PubMed ID: 27993660

  • 1. Much more than you expected: The non-DHFR-mediated effects of methotrexate.
    Sramek M, Neradil J, Veselska R.
    Biochim Biophys Acta Gen Subj; 2017 Mar; 1861(3):499-503. PubMed ID: 27993660
    [Abstract] [Full Text] [Related]

  • 2. New mechanisms for an old drug; DHFR- and non-DHFR-mediated effects of methotrexate in cancer cells.
    Neradil J, Pavlasova G, Veselska R.
    Klin Onkol; 2012 Mar; 25 Suppl 2():2S87-92. PubMed ID: 23581023
    [Abstract] [Full Text] [Related]

  • 3. Molecular mechanisms of resistance to antifolates, a review.
    Banerjee D, Ercikan-Abali E, Waltham M, Schnieders B, Hochhauser D, Li WW, Fan J, Gorlick R, Goker E, Bertino JR.
    Acta Biochim Pol; 1995 Mar; 42(4):457-64. PubMed ID: 8852336
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  • 4. Methotrexate-based PROTACs as DHFR-specific chemical probes.
    Rana S, Dranchak P, Dahlin JL, Lamy L, Li W, Oliphant E, Shrimp JH, Rajacharya GH, Tharakan R, Holland DO, Whitten AS, Wilson KM, Singh PK, Durum SK, Tao D, Rai G, Inglese J.
    Cell Chem Biol; 2024 Feb 15; 31(2):221-233.e14. PubMed ID: 37875111
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  • 5. Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates.
    Goldman ID, Matherly LH.
    NCI Monogr; 1987 Feb 15; (5):17-26. PubMed ID: 2448654
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  • 6. Cancer research: from folate antagonism to molecular targets.
    Bertino JR.
    Best Pract Res Clin Haematol; 2009 Dec 15; 22(4):577-82. PubMed ID: 19959110
    [Abstract] [Full Text] [Related]

  • 7. Anticancer antifolates: current status and future directions.
    McGuire JJ.
    Curr Pharm Des; 2003 Dec 15; 9(31):2593-613. PubMed ID: 14529544
    [Abstract] [Full Text] [Related]

  • 8. Further studies on the pharmacologic effects of the 7-hydroxy catabolite of methotrexate in the L1210 murine leukemia cell.
    Seither RL, Rape TJ, Goldman ID.
    Biochem Pharmacol; 1989 Mar 01; 38(5):815-22. PubMed ID: 2467676
    [Abstract] [Full Text] [Related]

  • 9. Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
    Rhee MS, Galivan J, Wright JE, Rosowsky A.
    Mol Pharmacol; 1994 Apr 01; 45(4):783-91. PubMed ID: 7514264
    [Abstract] [Full Text] [Related]

  • 10. Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein II and folate receptor alpha that, upon folate repletion, confer drug resistance to CHL cells.
    Zhu WY, Bunni M, Priest DG, DiCapua JL, Dressler JM, Chen Z, Melera PW.
    J Exp Ther Oncol; 2002 Apr 01; 2(5):264-77. PubMed ID: 12416030
    [Abstract] [Full Text] [Related]

  • 11. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H, Niethammer D, Jackson RC.
    Cancer Res; 1983 Nov 01; 43(11):5286-92. PubMed ID: 6225514
    [Abstract] [Full Text] [Related]

  • 12. In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics.
    Rana RM, Rampogu S, Abid NB, Zeb A, Parate S, Lee G, Yoon S, Kim Y, Kim D, Lee KW.
    Molecules; 2020 Jul 31; 25(15):. PubMed ID: 32752079
    [Abstract] [Full Text] [Related]

  • 13. Investigation on inhibitory effect of folic acid on methotrexate-induced epithelial-mesenchymal transition focusing on dihydrofolate reductase.
    Kawami M, Honda N, Hara T, Yumoto R, Takano M.
    Drug Metab Pharmacokinet; 2019 Dec 31; 34(6):396-399. PubMed ID: 31601464
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  • 19. Characterization and comparative studies of zebrafish and human recombinant dihydrofolate reductases--inhibition by folic acid and polyphenols.
    Kao TT, Wang KC, Chang WN, Lin CY, Chen BH, Wu HL, Shi GY, Tsai JN, Fu TF.
    Drug Metab Dispos; 2008 Mar 31; 36(3):508-16. PubMed ID: 18056255
    [Abstract] [Full Text] [Related]

  • 20. Drug-resistant dihydrofolate reductases: generation, expression and therapeutic application.
    McIvor RS.
    Bone Marrow Transplant; 1996 Dec 31; 18 Suppl 3():S50-4. PubMed ID: 8971409
    [Abstract] [Full Text] [Related]

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