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141 related items for PubMed ID: 28116898

  • 1. Engineering 7β-Hydroxysteroid Dehydrogenase for Enhanced Ursodeoxycholic Acid Production by Multiobjective Directed Evolution.
    Zheng MM, Chen KC, Wang RF, Li H, Li CX, Xu JH.
    J Agric Food Chem; 2017 Feb 15; 65(6):1178-1185. PubMed ID: 28116898
    [Abstract] [Full Text] [Related]

  • 2. Enhanced activity and substrate tolerance of 7α-hydroxysteroid dehydrogenase by directed evolution for 7-ketolithocholic acid production.
    Huang B, Zhao Q, Zhou JH, Xu G.
    Appl Microbiol Biotechnol; 2019 Mar 15; 103(6):2665-2674. PubMed ID: 30734123
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  • 3. Contribution of the 7β-hydroxysteroid dehydrogenase from Ruminococcus gnavus N53 to ursodeoxycholic acid formation in the human colon.
    Lee JY, Arai H, Nakamura Y, Fukiya S, Wada M, Yokota A.
    J Lipid Res; 2013 Nov 15; 54(11):3062-9. PubMed ID: 23729502
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  • 4. Multi-enzymatic one-pot reduction of dehydrocholic acid to 12-keto-ursodeoxycholic acid with whole-cell biocatalysts.
    Sun B, Kantzow C, Bresch S, Castiglione K, Weuster-Botz D.
    Biotechnol Bioeng; 2013 Jan 15; 110(1):68-77. PubMed ID: 22806613
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  • 5. Sequence and structure-guided discovery of a novel NADH-dependent 7β-hydroxysteroid dehydrogenase for efficient biosynthesis of ursodeoxycholic acid.
    Huang B, Yang K, Amanze C, Yan Z, Zhou H, Liu X, Qiu G, Zeng W.
    Bioorg Chem; 2023 Feb 15; 131():106340. PubMed ID: 36586301
    [Abstract] [Full Text] [Related]

  • 6. Engineering of a hydroxysteroid dehydrogenase with simultaneous enhancement in activity and thermostability for efficient biosynthesis of ursodeoxycholic acid.
    Li Y, Li S-F, Zhang L, Xue Y-P, Zheng Y-G.
    Appl Environ Microbiol; 2024 Sep 18; 90(9):e0123724. PubMed ID: 39207158
    [Abstract] [Full Text] [Related]

  • 7. Machine-Learning-Guided Engineering of an NADH-Dependent 7β-Hydroxysteroid Dehydrogenase for Economic Synthesis of Ursodeoxycholic Acid.
    Wang MQ, You ZN, Yang BY, Xia ZW, Chen Q, Pan J, Li CX, Xu JH.
    J Agric Food Chem; 2023 Dec 13; 71(49):19672-19681. PubMed ID: 38016669
    [Abstract] [Full Text] [Related]

  • 8. Structure of NADP+-bound 7β-hydroxysteroid dehydrogenase reveals two cofactor-binding modes.
    Wang R, Wu J, Jin DK, Chen Y, Lv Z, Chen Q, Miao Q, Huo X, Wang F.
    Acta Crystallogr F Struct Biol Commun; 2017 May 01; 73(Pt 5):246-252. PubMed ID: 28471355
    [Abstract] [Full Text] [Related]

  • 9. Large-scale production of ursodeoxycholic acid from chenodeoxycholic acid by engineering 7α- and 7β-hydroxysteroid dehydrogenase.
    Zhang X, Fan D, Hua X, Zhang T.
    Bioprocess Biosyst Eng; 2019 Sep 01; 42(9):1537-1545. PubMed ID: 31152232
    [Abstract] [Full Text] [Related]

  • 10. Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7β-hydroxysteroid dehydrogenase from Collinsella aerofaciens.
    Liu L, Aigner A, Schmid RD.
    Appl Microbiol Biotechnol; 2011 Apr 01; 90(1):127-35. PubMed ID: 21181147
    [Abstract] [Full Text] [Related]

  • 11. Continuous Production of Ursodeoxycholic Acid by Using Two Cascade Reactors with Co-immobilized Enzymes.
    Zheng MM, Chen FF, Li H, Li CX, Xu JH.
    Chembiochem; 2018 Feb 16; 19(4):347-353. PubMed ID: 28926166
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  • 18. Engineering Regioselectivity of a P450 Monooxygenase Enables the Synthesis of Ursodeoxycholic Acid via 7β-Hydroxylation of Lithocholic Acid.
    Grobe S, Badenhorst CPS, Bayer T, Hamnevik E, Wu S, Grathwol CW, Link A, Koban S, Brundiek H, Großjohann B, Bornscheuer UT.
    Angew Chem Int Ed Engl; 2021 Jan 11; 60(2):753-757. PubMed ID: 33085147
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