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Journal Abstract Search

404 related items for PubMed ID: 28122327

  • 1. Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy.
    Mahne AE, Mauze S, Joyce-Shaikh B, Xia J, Bowman EP, Beebe AM, Cua DJ, Jain R.
    Cancer Res; 2017 Mar 01; 77(5):1108-1118. PubMed ID: 28122327
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  • 2. Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells.
    Sukumar S, Wilson DC, Yu Y, Wong J, Naravula S, Ermakov G, Riener R, Bhagwat B, Necheva AS, Grein J, Churakova T, Mangadu R, Georgiev P, Manfra D, Pinheiro EM, Sriram V, Bailey WJ, Herzyk D, McClanahan TK, Willingham A, Beebe AM, Sadekova S.
    Cancer Res; 2017 Aug 15; 77(16):4378-4388. PubMed ID: 28611044
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  • 3. Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted.
    Kim YH, Shin SM, Choi BK, Oh HS, Kim CH, Lee SJ, Kim KH, Lee DG, Park SH, Kwon BS.
    J Immunol; 2015 Nov 15; 195(10):4721-9. PubMed ID: 26423152
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  • 4. Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy.
    Coe D, Begom S, Addey C, White M, Dyson J, Chai JG.
    Cancer Immunol Immunother; 2010 Sep 15; 59(9):1367-77. PubMed ID: 20480365
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  • 5. Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation.
    Cohen AD, Schaer DA, Liu C, Li Y, Hirschhorn-Cymmerman D, Kim SC, Diab A, Rizzuto G, Duan F, Perales MA, Merghoub T, Houghton AN, Wolchok JD.
    PLoS One; 2010 May 03; 5(5):e10436. PubMed ID: 20454651
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  • 7. Anti-GITR Antibody Treatment Increases TCR Repertoire Diversity of Regulatory but not Effector T Cells Engaged in the Immune Response Against B16 Melanoma.
    Scirka B, Szurek E, Pietrzak M, Rempala G, Kisielow P, Ignatowicz L, Miazek A.
    Arch Immunol Ther Exp (Warsz); 2017 Dec 03; 65(6):553-564. PubMed ID: 28638937
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  • 9. Rational design of anti-GITR-based combination immunotherapy.
    Zappasodi R, Sirard C, Li Y, Budhu S, Abu-Akeel M, Liu C, Yang X, Zhong H, Newman W, Qi J, Wong P, Schaer D, Koon H, Velcheti V, Hellmann MD, Postow MA, Callahan MK, Wolchok JD, Merghoub T.
    Nat Med; 2019 May 03; 25(5):759-766. PubMed ID: 31036879
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  • 12. Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs.
    Lu L, Xu X, Zhang B, Zhang R, Ji H, Wang X.
    J Transl Med; 2014 Feb 07; 12():36. PubMed ID: 24502656
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  • 13. GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability.
    Schaer DA, Budhu S, Liu C, Bryson C, Malandro N, Cohen A, Zhong H, Yang X, Houghton AN, Merghoub T, Wolchok JD.
    Cancer Immunol Res; 2013 Nov 07; 1(5):320-31. PubMed ID: 24416730
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  • 18. Anti-glucocorticoid-induced Tumor Necrosis Factor-Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects.
    Schoenhals JE, Cushman TR, Barsoumian HB, Li A, Cadena AP, Niknam S, Younes AI, Caetano MDS, Cortez MA, Welsh JW.
    Front Immunol; 2018 Nov 07; 9():2170. PubMed ID: 30294332
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  • 19. T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy.
    Snell LM, Lin GH, McPherson AJ, Moraes TJ, Watts TH.
    Immunol Rev; 2011 Nov 07; 244(1):197-217. PubMed ID: 22017440
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