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Journal Abstract Search

525 related items for PubMed ID: 28126008

  • 1. Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency.
    Zhou X, Sun L, Brady OA, Murphy KA, Hu F.
    Acta Neuropathol Commun; 2017 Jan 26; 5(1):9. PubMed ID: 28126008
    [Abstract] [Full Text] [Related]

  • 2. Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice.
    Feng T, Mai S, Roscoe JM, Sheng RR, Ullah M, Zhang J, Katz II, Yu H, Xiong W, Hu F.
    EMBO Rep; 2020 Oct 05; 21(10):e50219. PubMed ID: 32852886
    [Abstract] [Full Text] [Related]

  • 3. Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.
    Busch JI, Martinez-Lage M, Ashbridge E, Grossman M, Van Deerlin VM, Hu F, Lee VM, Trojanowski JQ, Chen-Plotkin AS.
    Acta Neuropathol Commun; 2013 Jul 11; 1():36. PubMed ID: 24252750
    [Abstract] [Full Text] [Related]

  • 4. TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.
    Chen-Plotkin AS, Unger TL, Gallagher MD, Bill E, Kwong LK, Volpicelli-Daley L, Busch JI, Akle S, Grossman M, Van Deerlin V, Trojanowski JQ, Lee VM.
    J Neurosci; 2012 Aug 15; 32(33):11213-27. PubMed ID: 22895706
    [Abstract] [Full Text] [Related]

  • 5. Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.
    Arrant AE, Nicholson AM, Zhou X, Rademakers R, Roberson ED.
    Mol Neurodegener; 2018 Jun 22; 13(1):32. PubMed ID: 29929528
    [Abstract] [Full Text] [Related]

  • 6. The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.
    Brady OA, Zheng Y, Murphy K, Huang M, Hu F.
    Hum Mol Genet; 2013 Feb 15; 22(4):685-95. PubMed ID: 23136129
    [Abstract] [Full Text] [Related]

  • 7. Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.
    Klein ZA, Takahashi H, Ma M, Stagi M, Zhou M, Lam TT, Strittmatter SM.
    Neuron; 2017 Jul 19; 95(2):281-296.e6. PubMed ID: 28728022
    [Abstract] [Full Text] [Related]

  • 8. Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.
    Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A.
    Acta Neuropathol; 2014 Jul 19; 127(6):845-60. PubMed ID: 24619111
    [Abstract] [Full Text] [Related]

  • 9. Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.
    Zhou X, Brooks M, Jiang P, Koga S, Zuberi AR, Baker MC, Parsons TM, Castanedes-Casey M, Phillips V, Librero AL, Kurti A, Fryer JD, Bu G, Lutz C, Dickson DW, Rademakers R.
    EMBO Rep; 2020 Oct 05; 21(10):e50197. PubMed ID: 32761777
    [Abstract] [Full Text] [Related]

  • 10. Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.
    Zhou X, Sun L, Bracko O, Choi JW, Jia Y, Nana AL, Brady OA, Hernandez JCC, Nishimura N, Seeley WW, Hu F.
    Nat Commun; 2017 May 25; 8():15277. PubMed ID: 28541286
    [Abstract] [Full Text] [Related]

  • 11. Lysosomal processing of progranulin.
    Zhou X, Paushter DH, Feng T, Sun L, Reinheckel T, Hu F.
    Mol Neurodegener; 2017 Aug 23; 12(1):62. PubMed ID: 28835281
    [Abstract] [Full Text] [Related]

  • 12. TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.
    Nicholson AM, Finch NA, Wojtas A, Baker MC, Perkerson RB, Castanedes-Casey M, Rousseau L, Benussi L, Binetti G, Ghidoni R, Hsiung GY, Mackenzie IR, Finger E, Boeve BF, Ertekin-Taner N, Graff-Radford NR, Dickson DW, Rademakers R.
    J Neurochem; 2013 Sep 23; 126(6):781-91. PubMed ID: 23742080
    [Abstract] [Full Text] [Related]

  • 13. Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.
    Busch JI, Unger TL, Jain N, Tyler Skrinak R, Charan RA, Chen-Plotkin AS.
    Hum Mol Genet; 2016 Jul 01; 25(13):2681-2697. PubMed ID: 27126638
    [Abstract] [Full Text] [Related]

  • 14. Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
    Werner G, Damme M, Schludi M, Gnörich J, Wind K, Fellerer K, Wefers B, Wurst W, Edbauer D, Brendel M, Haass C, Capell A.
    EMBO Rep; 2020 Oct 05; 21(10):e50241. PubMed ID: 32929860
    [Abstract] [Full Text] [Related]

  • 15. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice.
    Götzl JK, Colombo AV, Fellerer K, Reifschneider A, Werner G, Tahirovic S, Haass C, Capell A.
    Mol Neurodegener; 2018 Sep 04; 13(1):48. PubMed ID: 30180904
    [Abstract] [Full Text] [Related]

  • 16. Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration.
    Lang CM, Fellerer K, Schwenk BM, Kuhn PH, Kremmer E, Edbauer D, Capell A, Haass C.
    J Biol Chem; 2012 Jun 01; 287(23):19355-65. PubMed ID: 22511793
    [Abstract] [Full Text] [Related]

  • 17. The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.
    Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M.
    Cell Rep; 2020 Mar 10; 30(10):3506-3519.e6. PubMed ID: 32160553
    [Abstract] [Full Text] [Related]

  • 18. Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging.
    Perneel J, Neumann M, Heeman B, Cheung S, Van den Broeck M, Wynants S, Baker M, Vicente CT, Faura J, Rademakers R, Mackenzie IRA.
    Acta Neuropathol; 2023 Mar 10; 145(3):285-302. PubMed ID: 36527486
    [Abstract] [Full Text] [Related]

  • 19. Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.
    Cabron AS, Borgmeyer U, Richter J, Peisker H, Gutbrod K, Dörmann P, Capell A, Damme M.
    Acta Neuropathol Commun; 2023 Jan 27; 11(1):21. PubMed ID: 36707901
    [Abstract] [Full Text] [Related]

  • 20. Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation.
    Papegaey A, Eddarkaoui S, Deramecourt V, Fernandez-Gomez FJ, Pantano P, Obriot H, Machala C, Anquetil V, Camuzat A, Brice A, Maurage CA, Le Ber I, Duyckaerts C, Buée L, Sergeant N, Buée-Scherrer V.
    Acta Neuropathol Commun; 2016 Jul 19; 4(1):74. PubMed ID: 27435172
    [Abstract] [Full Text] [Related]

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