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Journal Abstract Search

643 related items for PubMed ID: 28140580

  • 1. Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry.
    Fronik P, Gaiser BI, Sejer Pedersen D.
    J Med Chem; 2017 May 25; 60(10):4126-4134. PubMed ID: 28140580
    [Abstract] [Full Text] [Related]

  • 2. Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors.
    Feng Z, Hu G, Ma S, Xie XQ.
    AAPS J; 2015 Sep 25; 17(5):1080-95. PubMed ID: 25940084
    [Abstract] [Full Text] [Related]

  • 3. Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs.
    Valant C, Sexton PM, Christopoulos A.
    Mol Interv; 2009 Jun 25; 9(3):125-35. PubMed ID: 19592673
    [Abstract] [Full Text] [Related]

  • 4. Bridging the gap: bitopic ligands of G-protein-coupled receptors.
    Lane JR, Sexton PM, Christopoulos A.
    Trends Pharmacol Sci; 2013 Jan 25; 34(1):59-66. PubMed ID: 23177916
    [Abstract] [Full Text] [Related]

  • 5. Recent Advances in the Drug Discovery and Development of Dualsteric/ Bitopic Activators of G Protein-Coupled Receptors.
    Reinecke BA, Wang H, Zhang Y.
    Curr Top Med Chem; 2019 Jan 25; 19(26):2378-2392. PubMed ID: 31833462
    [Abstract] [Full Text] [Related]

  • 6. Strategies for the identification of allosteric modulators of G-protein-coupled receptors.
    Burford NT, Watson J, Bertekap R, Alt A.
    Biochem Pharmacol; 2011 Mar 15; 81(6):691-702. PubMed ID: 21184747
    [Abstract] [Full Text] [Related]

  • 7. Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors.
    Mohr K, Schmitz J, Schrage R, Tränkle C, Holzgrabe U.
    Angew Chem Int Ed Engl; 2013 Jan 07; 52(2):508-16. PubMed ID: 23225228
    [Abstract] [Full Text] [Related]

  • 8. Current and Future Challenges in GPCR Drug Discovery.
    Topiol S.
    Methods Mol Biol; 2018 Jan 07; 1705():1-21. PubMed ID: 29188556
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  • 9. The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors.
    Valant C, Robert Lane J, Sexton PM, Christopoulos A.
    Annu Rev Pharmacol Toxicol; 2012 Jan 07; 52():153-78. PubMed ID: 21910627
    [Abstract] [Full Text] [Related]

  • 10. Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands.
    Gado F, Ferrisi R, Polini B, Mohamed KA, Ricardi C, Lucarini E, Carpi S, Domenichini F, Stevenson LA, Rapposelli S, Saccomanni G, Nieri P, Ortore G, Pertwee RG, Ghelardini C, Di Cesare Mannelli L, Chiellini G, Laprairie RB, Manera C.
    J Med Chem; 2022 Jul 28; 65(14):9918-9938. PubMed ID: 35849804
    [Abstract] [Full Text] [Related]

  • 11. Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands.
    Gaiser BI, Danielsen M, Marcher-Rørsted E, Røpke Jørgensen K, Wróbel TM, Frykman M, Johansson H, Bräuner-Osborne H, Gloriam DE, Mathiesen JM, Sejer Pedersen D.
    J Med Chem; 2019 Sep 12; 62(17):7806-7839. PubMed ID: 31298548
    [Abstract] [Full Text] [Related]

  • 12. Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.
    Keov P, Sexton PM, Christopoulos A.
    Neuropharmacology; 2011 Jan 12; 60(1):24-35. PubMed ID: 20637785
    [Abstract] [Full Text] [Related]

  • 13. Advances in G protein-coupled receptor allostery: from function to structure.
    Christopoulos A.
    Mol Pharmacol; 2014 Nov 12; 86(5):463-78. PubMed ID: 25061106
    [Abstract] [Full Text] [Related]

  • 14. Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule.
    Egyed A, Kelemen ÁA, Vass M, Visegrády A, Thee SA, Wang Z, de Graaf C, Brea J, Loza MI, Leurs R, Keserű GM.
    Bioorg Chem; 2021 Jun 12; 111():104832. PubMed ID: 33826962
    [Abstract] [Full Text] [Related]

  • 15. Allosteric ligands for G protein-coupled receptors: a novel strategy with attractive therapeutic opportunities.
    De Amici M, Dallanoce C, Holzgrabe U, Tränkle C, Mohr K.
    Med Res Rev; 2010 May 12; 30(3):463-549. PubMed ID: 19557759
    [Abstract] [Full Text] [Related]

  • 16. Overview of receptor allosterism.
    Gregory KJ, Sexton PM, Christopoulos A.
    Curr Protoc Pharmacol; 2010 Dec 12; Chapter 1():Unit 1.21. PubMed ID: 21935895
    [Abstract] [Full Text] [Related]

  • 17. Allosteric binding sites at the receptor-lipid bilayer interface: novel targets for GPCR drug discovery.
    Wang Y, Yu Z, Xiao W, Lu S, Zhang J.
    Drug Discov Today; 2021 Mar 12; 26(3):690-703. PubMed ID: 33301977
    [Abstract] [Full Text] [Related]

  • 18. Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators.
    Grundmann M, Bender E, Schamberger J, Eitner F.
    Int J Mol Sci; 2021 Feb 10; 22(4):. PubMed ID: 33578942
    [Abstract] [Full Text] [Related]

  • 19. 2016 Philip S. Portoghese Medicinal Chemistry Lectureship: Designing Bivalent or Bitopic Molecules for G-Protein Coupled Receptors. The Whole Is Greater Than the Sum of Its Parts.
    Newman AH, Battiti FO, Bonifazi A.
    J Med Chem; 2020 Mar 12; 63(5):1779-1797. PubMed ID: 31499001
    [Abstract] [Full Text] [Related]

  • 20. Allosteric modulators of G-protein-coupled receptors.
    May LT, Christopoulos A.
    Curr Opin Pharmacol; 2003 Oct 12; 3(5):551-6. PubMed ID: 14559102
    [Abstract] [Full Text] [Related]

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