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Journal Abstract Search

239 related items for PubMed ID: 28286018

  • 1. Acyl glucuronide metabolites: Implications for drug safety assessment.
    Van Vleet TR, Liu H, Lee A, Blomme EAG.
    Toxicol Lett; 2017 Apr 15; 272():1-7. PubMed ID: 28286018
    [Abstract] [Full Text] [Related]

  • 2. Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes.
    Darnell M, Breitholtz K, Isin EM, Jurva U, Weidolf L.
    Chem Res Toxicol; 2015 May 18; 28(5):886-96. PubMed ID: 25803559
    [Abstract] [Full Text] [Related]

  • 3. Acyl glucuronide reactivity in perspective: biological consequences.
    Bailey MJ, Dickinson RG.
    Chem Biol Interact; 2003 May 06; 145(2):117-37. PubMed ID: 12686489
    [Abstract] [Full Text] [Related]

  • 4. A New Rapid In Vitro Assay for Assessing Reactivity of Acyl Glucuronides.
    Zhong S, Jones R, Lu W, Schadt S, Ottaviani G.
    Drug Metab Dispos; 2015 Nov 06; 43(11):1711-7. PubMed ID: 26276581
    [Abstract] [Full Text] [Related]

  • 5. Acyl glucuronides: the good, the bad and the ugly.
    Regan SL, Maggs JL, Hammond TG, Lambert C, Williams DP, Park BK.
    Biopharm Drug Dispos; 2010 Oct 06; 31(7):367-95. PubMed ID: 20830700
    [Abstract] [Full Text] [Related]

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  • 7. Development of an in vitro screening model for the biosynthesis of acyl glucuronide metabolites and the assessment of their reactivity toward human serum albumin.
    Bolze S, Bromet N, Gay-Feutry C, Massiere F, Boulieu R, Hulot T.
    Drug Metab Dispos; 2002 Apr 06; 30(4):404-13. PubMed ID: 11901094
    [Abstract] [Full Text] [Related]

  • 8. Safety Assessment of Acyl Glucuronides-A Simplified Paradigm.
    Smith DA, Hammond T, Baillie TA.
    Drug Metab Dispos; 2018 Jun 06; 46(6):908-912. PubMed ID: 29559442
    [Abstract] [Full Text] [Related]

  • 9. Hepatic disposition of electrophilic acyl glucuronide conjugates.
    Sallustio BC, Sabordo L, Evans AM, Nation RL.
    Curr Drug Metab; 2000 Sep 06; 1(2):163-80. PubMed ID: 11465081
    [Abstract] [Full Text] [Related]

  • 10. Differentiation of Deprotonated Acyl-, N-, and O-Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion-Molecule Reactions Followed by Collision-Activated Dissociation.
    Niyonsaba E, Easton MW, Feng E, Yu Z, Zhang Z, Sheng H, Kong J, Easterling LF, Milton J, Chobanian HR, Deprez NR, Cancilla MT, Kilaz G, Kenttämaa HI.
    Anal Chem; 2019 Sep 03; 91(17):11388-11396. PubMed ID: 31381321
    [Abstract] [Full Text] [Related]

  • 11. Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy.
    Walker GS, Atherton J, Bauman J, Kohl C, Lam W, Reily M, Lou Z, Mutlib A.
    Chem Res Toxicol; 2007 Jun 03; 20(6):876-86. PubMed ID: 17536843
    [Abstract] [Full Text] [Related]

  • 12. Acyl glucuronide drug metabolites: toxicological and analytical implications.
    Shipkova M, Armstrong VW, Oellerich M, Wieland E.
    Ther Drug Monit; 2003 Feb 03; 25(1):1-16. PubMed ID: 12548138
    [Abstract] [Full Text] [Related]

  • 13. A novel approach for predicting acyl glucuronide reactivity via Schiff base formation: development of rapidly formed peptide adducts for LC/MS/MS measurements.
    Wang J, Davis M, Li F, Azam F, Scatina J, Talaat R.
    Chem Res Toxicol; 2004 Sep 03; 17(9):1206-16. PubMed ID: 15377154
    [Abstract] [Full Text] [Related]

  • 14. Acyl glucuronide reactivity in perspective.
    Bradshaw PR, Athersuch TJ, Stachulski AV, Wilson ID.
    Drug Discov Today; 2020 Sep 03; 25(9):1639-1650. PubMed ID: 32681884
    [Abstract] [Full Text] [Related]

  • 15. Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester.
    Shang J, Tschirret-Guth R, Cancilla M, Samuel K, Chen Q, Chobanian HR, Thomas A, Tong W, Josien H, Buevich AV, Mitra K.
    Chem Res Toxicol; 2020 Jan 21; 33(1):191-201. PubMed ID: 31566356
    [Abstract] [Full Text] [Related]

  • 16. New Perspectives on Acyl Glucuronide Risk Assessment in Drug Discovery: Investigation of In vitro Stability, In situ Reactivity, and Bioactivation.
    Gunduz M, Argikar UA, Cirello AL, Dumouchel JL.
    Drug Metab Lett; 2018 Jan 21; 12(2):84-92. PubMed ID: 29886840
    [Abstract] [Full Text] [Related]

  • 17. New Perspectives on Drug-Induced Liver Injury Risk Assessment of Acyl Glucuronides.
    Walles M, Brown AP, Zimmerlin A, End P.
    Chem Res Toxicol; 2020 Jul 20; 33(7):1551-1560. PubMed ID: 32525307
    [Abstract] [Full Text] [Related]

  • 18. Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated.
    Lassila T, Hokkanen J, Aatsinki SM, Mattila S, Turpeinen M, Tolonen A.
    Chem Res Toxicol; 2015 Dec 21; 28(12):2292-303. PubMed ID: 26558897
    [Abstract] [Full Text] [Related]

  • 19. The generation, detection, and effects of reactive drug metabolites.
    Stachulski AV, Baillie TA, Park BK, Obach RS, Dalvie DK, Williams DP, Srivastava A, Regan SL, Antoine DJ, Goldring CE, Chia AJ, Kitteringham NR, Randle LE, Callan H, Castrejon JL, Farrell J, Naisbitt DJ, Lennard MS.
    Med Res Rev; 2013 Sep 21; 33(5):985-1080. PubMed ID: 23090860
    [Abstract] [Full Text] [Related]

  • 20. Correlation between glucuronidation and covalent adducts formation with proteins of nonsteroidal anti-inflammatory drugs.
    Shimada H, Kobayashi Y, Tanahashi S, Kawase A, Ogiso T, Iwaki M.
    Eur J Pharm Sci; 2018 Jan 15; 112():132-138. PubMed ID: 29174986
    [Abstract] [Full Text] [Related]

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