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PUBMED FOR HANDHELDS

Journal Abstract Search


184 related items for PubMed ID: 28388050

  • 1. CNS Physicochemical Property Space Shaped by a Diverse Set of Molecules with Experimentally Determined Exposure in the Mouse Brain.
    Rankovic Z.
    J Med Chem; 2017 Jul 27; 60(14):5943-5954. PubMed ID: 28388050
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  • 2. CNS drug design: balancing physicochemical properties for optimal brain exposure.
    Rankovic Z.
    J Med Chem; 2015 Mar 26; 58(6):2584-608. PubMed ID: 25494650
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  • 5. Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System.
    Zhang YY, Liu H, Summerfield SG, Luscombe CN, Sahi J.
    Mol Pharm; 2016 May 02; 13(5):1540-50. PubMed ID: 27015243
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  • 6. Technically Extended MultiParameter Optimization (TEMPO): An Advanced Robust Scoring Scheme To Calculate Central Nervous System Druggability and Monitor Lead Optimization.
    Ghose AK, Ott GR, Hudkins RL.
    ACS Chem Neurosci; 2017 Jan 18; 8(1):147-154. PubMed ID: 27741392
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  • 12. Demystifying brain penetration in central nervous system drug discovery. Miniperspective.
    Di L, Rong H, Feng B.
    J Med Chem; 2013 Jan 10; 56(1):2-12. PubMed ID: 23075026
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  • 13. A new descriptor via bio-mimetic chromatography and modeling for the blood brain barrier (Part II).
    Kouskoura MG, Piteni AI, Markopoulou CK.
    J Pharm Biomed Anal; 2019 Feb 05; 164():808-817. PubMed ID: 29884296
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  • 14. Start small and stay small. Minimizing attrition in the clinic with a focus on CNS therapeutics.
    Nienaber V.
    Curr Top Med Chem; 2009 Feb 05; 9(18):1688-704. PubMed ID: 19929834
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  • 15. Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes.
    Wager TT, Chandrasekaran RY, Hou X, Troutman MD, Verhoest PR, Villalobos A, Will Y.
    ACS Chem Neurosci; 2010 Jun 16; 1(6):420-34. PubMed ID: 22778836
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  • 16. Predicting efflux ratios and blood-brain barrier penetration from chemical structure: combining passive permeability with active efflux by P-glycoprotein.
    Dolghih E, Jacobson MP.
    ACS Chem Neurosci; 2013 Feb 20; 4(2):361-7. PubMed ID: 23421687
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  • 20. Computational prediction of CNS drug exposure based on a novel in vivo dataset.
    Bergström CA, Charman SA, Nicolazzo JA.
    Pharm Res; 2012 Nov 20; 29(11):3131-42. PubMed ID: 22744815
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