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372 related items for PubMed ID: 28442322
1. In vitro and in vivo antitumor activities of T-3764518, a novel and orally available small molecule stearoyl-CoA desaturase 1 inhibitor. Nishizawa S, Sumi H, Satoh Y, Yamamoto Y, Kitazawa S, Honda K, Araki H, Kakoi K, Imamura K, Sasaki M, Miyahisa I, Satomi Y, Nishigaki R, Hirayama M, Aoyama K, Maezaki H, Hara T. Eur J Pharmacol; 2017 Jul 15; 807():21-31. PubMed ID: 28442322 [Abstract] [Full Text] [Related]
2. Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents. Imamura K, Tomita N, Kawakita Y, Ito Y, Ono K, Nii N, Miyazaki T, Yonemori K, Tawada M, Sumi H, Satoh Y, Yamamoto Y, Miyahisa I, Sasaki M, Satomi Y, Hirayama M, Nishigaki R, Maezaki H. Bioorg Med Chem; 2017 Jul 15; 25(14):3768-3779. PubMed ID: 28571972 [Abstract] [Full Text] [Related]
3. Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition. Ono A, Sano O, Kazetani KI, Muraki T, Imamura K, Sumi H, Matsui J, Iwata H. PLoS One; 2017 Jul 15; 12(7):e0181243. PubMed ID: 28704514 [Abstract] [Full Text] [Related]
4. Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors. Liu G, Lynch JK, Freeman J, Liu B, Xin Z, Zhao H, Serby MD, Kym PR, Suhar TS, Smith HT, Cao N, Yang R, Janis RS, Krauser JA, Cepa SP, Beno DW, Sham HL, Collins CA, Surowy TK, Camp HS. J Med Chem; 2007 Jun 28; 50(13):3086-100. PubMed ID: 17530838 [Abstract] [Full Text] [Related]
5. Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy. Roongta UV, Pabalan JG, Wang X, Ryseck RP, Fargnoli J, Henley BJ, Yang WP, Zhu J, Madireddi MT, Lawrence RM, Wong TW, Rupnow BA. Mol Cancer Res; 2011 Nov 28; 9(11):1551-61. PubMed ID: 21954435 [Abstract] [Full Text] [Related]
6. 4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs. Yang SM, Tang Y, Rano T, Lu H, Kuo GH, Gaul MD, Li Y, Ho G, Lang W, Conway JG, Liang Y, Lenhard JM, Demarest KT, Murray WV. Bioorg Med Chem Lett; 2014 Mar 01; 24(5):1437-41. PubMed ID: 24405703 [Abstract] [Full Text] [Related]
7. Exogenous lipids promote the growth of breast cancer cells via CD36. Zhao J, Zhi Z, Wang C, Xing H, Song G, Yu X, Zhu Y, Wang X, Zhang X, Di Y. Oncol Rep; 2017 Oct 01; 38(4):2105-2115. PubMed ID: 28765876 [Abstract] [Full Text] [Related]
8. Blockade of Stearoyl-CoA-desaturase 1 activity reverts resistance to cisplatin in lung cancer stem cells. Pisanu ME, Noto A, De Vitis C, Morrone S, Scognamiglio G, Botti G, Venuta F, Diso D, Jakopin Z, Padula F, Ricci A, Mariotta S, Giovagnoli MR, Giarnieri E, Amelio I, Agostini M, Melino G, Ciliberto G, Mancini R. Cancer Lett; 2017 Oct 10; 406():93-104. PubMed ID: 28797843 [Abstract] [Full Text] [Related]
9. Discovery and pharmacological characterization of SAR707 as novel and selective small molecule inhibitor of stearoyl-CoA desaturase (SCD1). Voss MD, Zoller G, Matter H, Herling AW, Biemer-Daub G, Pfenninger A, Haag-Diergarten S, Keil S, Kohlmann M, Schmidts HL. Eur J Pharmacol; 2013 May 05; 707(1-3):140-6. PubMed ID: 23524088 [Abstract] [Full Text] [Related]
10. Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avancès C, Allory Y, de la Taille A, Culine S, Blancou H, Cristol JP, Michel F, Sardet C, Fajas L. Mol Cancer Ther; 2010 Jun 05; 9(6):1740-54. PubMed ID: 20530718 [Abstract] [Full Text] [Related]
11. Stearoyl-CoA Desaturase-1 Protects Cells against Lipotoxicity-Mediated Apoptosis in Proximal Tubular Cells. Iwai T, Kume S, Chin-Kanasaki M, Kuwagata S, Araki H, Takeda N, Sugaya T, Uzu T, Maegawa H, Araki SI. Int J Mol Sci; 2016 Nov 09; 17(11):. PubMed ID: 27834856 [Abstract] [Full Text] [Related]
12. FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth. Du X, Wang QR, Chan E, Merchant M, Liu J, French D, Ashkenazi A, Qing J. Cancer Res; 2012 Nov 15; 72(22):5843-55. PubMed ID: 23019225 [Abstract] [Full Text] [Related]
13. Development of a novel LC/MS method to quantitate cellular stearoyl-CoA desaturase activity. Dillon R, Greig MJ, Bhat BG. Anal Chim Acta; 2008 Oct 03; 627(1):99-104. PubMed ID: 18790132 [Abstract] [Full Text] [Related]
14. Stearoyl CoA Desaturase Is Essential for Regulation of Endoplasmic Reticulum Homeostasis and Tumor Growth in Glioblastoma Cancer Stem Cells. Pinkham K, Park DJ, Hashemiaghdam A, Kirov AB, Adam I, Rosiak K, da Hora CC, Teng J, Cheah PS, Carvalho L, Ganguli-Indra G, Kelly A, Indra AK, Badr CE. Stem Cell Reports; 2019 Apr 09; 12(4):712-727. PubMed ID: 30930246 [Abstract] [Full Text] [Related]
15. Oleic acid stimulation of motility of human extravillous trophoblast cells is mediated by stearoyl-CoA desaturase-1 activity. Yang C, Lim W, Bazer FW, Song G. Mol Hum Reprod; 2017 Nov 01; 23(11):755-770. PubMed ID: 29117333 [Abstract] [Full Text] [Related]
16. Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway. Liu G, Kuang S, Cao R, Wang J, Peng Q, Sun C. FASEB J; 2019 Sep 01; 33(9):10089-10103. PubMed ID: 31199678 [Abstract] [Full Text] [Related]
17. Stearoyl-CoA desaturase activity in bovine cumulus cells protects the oocyte against saturated fatty acid stress. Aardema H, van Tol HTA, Wubbolts RW, Brouwers JFHM, Gadella BM, Roelen BAJ. Biol Reprod; 2017 May 01; 96(5):982-992. PubMed ID: 28486699 [Abstract] [Full Text] [Related]
18. Modulation of SCD1 activity in hepatocyte cell lines: evaluation of genomic stability and proliferation. de Lima Luna AC, Forti FL. Mol Cell Biochem; 2021 Sep 01; 476(9):3393-3405. PubMed ID: 33954906 [Abstract] [Full Text] [Related]
19. Stearoyl-CoA desaturase 1 inhibition induces ER stress-mediated apoptosis in ovarian cancer cells. Lee J, Jang S, Im J, Han Y, Kim S, Jo H, Wang W, Cho U, Kim SI, Seol A, Kim B, Song YS. J Ovarian Res; 2024 Apr 02; 17(1):73. PubMed ID: 38566208 [Abstract] [Full Text] [Related]
20. Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation. Ma MKF, Lau EYT, Leung DHW, Lo J, Ho NPY, Cheng LKW, Ma S, Lin CH, Copland JA, Ding J, Lo RCL, Ng IOL, Lee TKW. J Hepatol; 2017 Nov 02; 67(5):979-990. PubMed ID: 28647567 [Abstract] [Full Text] [Related] Page: [Next] [New Search]