These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

143 related items for PubMed ID: 28450154

  • 1. Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect.
    Zhang W, Zhang SL, Hu X, Tam KY.
    Eur J Pharm Sci; 2017 Dec 15; 110():93-100. PubMed ID: 28450154
    [Abstract] [Full Text] [Related]

  • 2. Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease.
    Naia L, Cunha-Oliveira T, Rodrigues J, Rosenstock TR, Oliveira A, Ribeiro M, Carmo C, Oliveira-Sousa SI, Duarte AI, Hayden MR, Rego AC.
    J Neurosci; 2017 Mar 08; 37(10):2776-2794. PubMed ID: 28123081
    [Abstract] [Full Text] [Related]

  • 3. Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity.
    Kwak CH, Jin L, Han JH, Han CW, Kim E, Cho M, Chung TW, Bae SJ, Jang SB, Ha KT.
    Int J Mol Sci; 2020 Aug 21; 21(17):. PubMed ID: 32825675
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells.
    Zhang SL, Zhang W, Yang Z, Hu X, Tam KY.
    Eur J Pharm Sci; 2017 Dec 15; 110():87-92. PubMed ID: 28347773
    [Abstract] [Full Text] [Related]

  • 5. A novel PDK1 inhibitor, JX06, inhibits glycolysis and induces apoptosis in multiple myeloma cells.
    Kawano Y, Sasano T, Arima Y, Kushima S, Tsujita K, Matsuoka M, Hata H.
    Biochem Biophys Res Commun; 2022 Jan 08; 587():153-159. PubMed ID: 34875534
    [Abstract] [Full Text] [Related]

  • 6. Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics.
    Zhang W, Hu X, Chakravarty H, Yang Z, Tam KY.
    ACS Comb Sci; 2018 Nov 12; 20(11):660-671. PubMed ID: 30350563
    [Abstract] [Full Text] [Related]

  • 7. ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells.
    Cesi G, Walbrecq G, Zimmer A, Kreis S, Haan C.
    Mol Cancer; 2017 Jun 08; 16(1):102. PubMed ID: 28595656
    [Abstract] [Full Text] [Related]

  • 8. Anemone rivularis inhibits pyruvate dehydrogenase kinase activity and tumor growth.
    Chung TW, Lee JH, Choi HJ, Park MJ, Kim EY, Han JH, Jang SB, Lee SO, Lee SW, Hang J, Yi LW, Ha KT.
    J Ethnopharmacol; 2017 May 05; 203():47-54. PubMed ID: 28341246
    [Abstract] [Full Text] [Related]

  • 9. Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships.
    Zhang SL, Yang Z, Hu X, Tam KY.
    Bioorg Med Chem Lett; 2018 Nov 15; 28(21):3441-3445. PubMed ID: 30266541
    [Abstract] [Full Text] [Related]

  • 10. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.
    Kaplon J, Zheng L, Meissl K, Chaneton B, Selivanov VA, Mackay G, van der Burg SH, Verdegaal EM, Cascante M, Shlomi T, Gottlieb E, Peeper DS.
    Nature; 2013 Jun 06; 498(7452):109-12. PubMed ID: 23685455
    [Abstract] [Full Text] [Related]

  • 11. Identification of pyruvate dehydrogenase kinase 1 inhibitors with anti-osteosarcoma activity.
    Fang A, Luo H, Liu L, Fan H, Zhou Y, Yao Y, Zhang Y.
    Bioorg Med Chem Lett; 2017 Dec 15; 27(24):5450-5453. PubMed ID: 29150396
    [Abstract] [Full Text] [Related]

  • 12. Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase.
    Kinnaird A, Dromparis P, Saleme B, Gurtu V, Watson K, Paulin R, Zervopoulos S, Stenson T, Sutendra G, Pink DB, Carmine-Simmen K, Moore R, Lewis JD, Michelakis ED.
    Eur Urol; 2016 Apr 15; 69(4):734-744. PubMed ID: 26433571
    [Abstract] [Full Text] [Related]

  • 13. Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors.
    Zhang W, Hu X, Zhou W, Tam KY.
    J Proteome Res; 2018 Sep 07; 17(9):3012-3021. PubMed ID: 30028142
    [Abstract] [Full Text] [Related]

  • 14. Ciprofloxacin Therapy Results in Mitigation of ATP Loss after Irradiation Combined with Wound Trauma: Preservation of Pyruvate Dehydrogenase and Inhibition of Pyruvate Dehydrogenase Kinase 1.
    Swift JM, Smith JT, Kiang JG.
    Radiat Res; 2015 Jun 07; 183(6):684-92. PubMed ID: 26010714
    [Abstract] [Full Text] [Related]

  • 15. Rational design of mitochondria-targeted pyruvate dehydrogenase kinase 1 inhibitors with improved selectivity and antiproliferative activity.
    Xu B, Yu Z, Xiang S, Li Y, Zhang SL, He Y.
    Eur J Med Chem; 2018 Jul 15; 155():275-284. PubMed ID: 29890389
    [Abstract] [Full Text] [Related]

  • 16. JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification.
    Sun W, Xie Z, Liu Y, Zhao D, Wu Z, Zhang D, Lv H, Tang S, Jin N, Jiang H, Tan M, Ding J, Luo C, Li J, Huang M, Geng M.
    Cancer Res; 2015 Nov 15; 75(22):4923-36. PubMed ID: 26483203
    [Abstract] [Full Text] [Related]

  • 17. Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation.
    Jin Y, Cai Q, Shenoy AK, Lim S, Zhang Y, Charles S, Tarrash M, Fu X, Kamarajugadda S, Trevino JG, Tan M, Lu J.
    Oncotarget; 2016 May 03; 7(18):25113-24. PubMed ID: 26848621
    [Abstract] [Full Text] [Related]

  • 18. Synthesis, cytotoxicity, apoptosis and molecular docking studies of novel phenylbutyrate derivatives as potential anticancer agents.
    Mostoufi A, Baghgoli R, Fereidoonnezhad M.
    Comput Biol Chem; 2019 Jun 03; 80():128-137. PubMed ID: 30952039
    [Abstract] [Full Text] [Related]

  • 19. Design and characterization of α-lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors.
    Lin HY, Han HW, Sun WX, Yang YS, Tang CY, Lu GH, Qi JL, Wang XM, Yang YH.
    Eur J Med Chem; 2018 Jan 20; 144():137-150. PubMed ID: 29268130
    [Abstract] [Full Text] [Related]

  • 20. Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1.
    Zhang SL, Yang Z, Hu X, Chakravarty H, Tam KY.
    Eur J Pharm Sci; 2018 Oct 15; 123():43-55. PubMed ID: 30012506
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 8.