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Journal Abstract Search

262 related items for PubMed ID: 28450422

  • 1. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.
    Humphries-Bickley T, Castillo-Pichardo L, Hernandez-O'Farrill E, Borrero-Garcia LD, Forestier-Roman I, Gerena Y, Blanco M, Rivera-Robles MJ, Rodriguez-Medina JR, Cubano LA, Vlaar CP, Dharmawardhane S.
    Mol Cancer Ther; 2017 May; 16(5):805-818. PubMed ID: 28450422
    [Abstract] [Full Text] [Related]

  • 2. Efficacy of Rac and Cdc42 Inhibitor MBQ-167 in Triple-negative Breast Cancer.
    Cruz-Collazo A, Ruiz-Calderon JF, Picon H, Borrero-Garcia LD, Lopez I, Castillo-Pichardo L, Del Mar Maldonado M, Duconge J, Medina JI, Bayro MJ, Hernández-O'Farrill E, Vlaar CP, Dharmawardhane S.
    Mol Cancer Ther; 2021 Dec; 20(12):2420-2432. PubMed ID: 34607932
    [Abstract] [Full Text] [Related]

  • 3. Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase.
    Montalvo-Ortiz BL, Castillo-Pichardo L, Hernández E, Humphries-Bickley T, De la Mota-Peynado A, Cubano LA, Vlaar CP, Dharmawardhane S.
    J Biol Chem; 2012 Apr 13; 287(16):13228-38. PubMed ID: 22383527
    [Abstract] [Full Text] [Related]

  • 4. Characterization of Novel Derivatives of MBQ-167, an inhibitor of the GTP-binding proteins Rac/Cdc42.
    Medina JI, Cruz-Collazo A, Del Mar Maldonado M, Gascot TM, Borrero-Garcia LD, Cooke M, Kazanietz MG, O'Farril EH, Vlaar CP, Dharmawardhane S.
    Cancer Res Commun; 2022 Dec 13; 2(12):1711-1726. PubMed ID: 36861094
    [Abstract] [Full Text] [Related]

  • 5. Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae.
    Rivera-Robles MJ, Medina-Velázquez J, Asencio-Torres GM, González-Crespo S, Rymond BC, Rodríguez-Medina J, Dharmawardhane S.
    Small GTPases; 2020 Nov 13; 11(6):430-440. PubMed ID: 29969362
    [Abstract] [Full Text] [Related]

  • 6. R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.
    Guo Y, Kenney SR, Muller CY, Adams S, Rutledge T, Romero E, Murray-Krezan C, Prekeris R, Sklar LA, Hudson LG, Wandinger-Ness A.
    Mol Cancer Ther; 2015 Oct 13; 14(10):2215-27. PubMed ID: 26206334
    [Abstract] [Full Text] [Related]

  • 7. Rac and Cdc42 inhibitors reduce macrophage function in breast cancer preclinical models.
    Torres-Sanchez A, Rivera-Robles M, Castillo-Pichardo L, Martínez-Ferrer M, Dorta-Estremera SM, Dharmawardhane S.
    Front Oncol; 2023 Oct 13; 13():1152458. PubMed ID: 37397366
    [Abstract] [Full Text] [Related]

  • 8. Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells.
    Baugher PJ, Krishnamoorthy L, Price JE, Dharmawardhane SF.
    Breast Cancer Res; 2005 Oct 13; 7(6):R965-74. PubMed ID: 16280046
    [Abstract] [Full Text] [Related]

  • 9. Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase.
    Shi HY, Stafford LJ, Liu Z, Liu M, Zhang M.
    Cell Motil Cytoskeleton; 2007 May 13; 64(5):338-46. PubMed ID: 17301947
    [Abstract] [Full Text] [Related]

  • 10. A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice.
    Zins K, Lucas T, Reichl P, Abraham D, Aharinejad S.
    PLoS One; 2013 May 13; 8(9):e74924. PubMed ID: 24040362
    [Abstract] [Full Text] [Related]

  • 11. Development of EHop-016: a small molecule inhibitor of Rac.
    Dharmawardhane S, Hernandez E, Vlaar C.
    Enzymes; 2013 May 13; 33 Pt A(Pt A):117-46. PubMed ID: 25033803
    [Abstract] [Full Text] [Related]

  • 12. Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways.
    Lim L, Manser E, Leung T, Hall C.
    Eur J Biochem; 1996 Dec 01; 242(2):171-85. PubMed ID: 8973630
    [Abstract] [Full Text] [Related]

  • 13. Targeting Rac and Cdc42 GTPases in Cancer.
    Maldonado MDM, Dharmawardhane S.
    Cancer Res; 2018 Jun 15; 78(12):3101-3111. PubMed ID: 29858187
    [Abstract] [Full Text] [Related]

  • 14. Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.
    Morrison Joly M, Williams MM, Hicks DJ, Jones B, Sanchez V, Young CD, Sarbassov DD, Muller WJ, Brantley-Sieders D, Cook RS.
    Breast Cancer Res; 2017 Jun 30; 19(1):74. PubMed ID: 28666462
    [Abstract] [Full Text] [Related]

  • 15. The role of Rho GTPases' substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study.
    Liu Y, Dou Y, Yan L, Yang X, He B, Kong L, Smith W.
    Biosci Rep; 2020 Jul 31; 40(7):. PubMed ID: 32578854
    [Abstract] [Full Text] [Related]

  • 16. Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.
    Zins K, Gunawardhana S, Lucas T, Abraham D, Aharinejad S.
    J Transl Med; 2013 Nov 27; 11():295. PubMed ID: 24279335
    [Abstract] [Full Text] [Related]

  • 17. Efficacy and delivery strategies of the dual Rac/Cdc42 inhibitor MBQ-167 in HER2 overexpressing breast cancer.
    Velázquez-Vega LE, Rivera-Robles M, Sánchez-Álvarez AO, Vivas-Mejía PE, Aponte-Reyes M, Cruz-Collazo AM, Grafals-Ruiz N, Dorta-Estremera S, Hernández-O'Farrill E, Vlaar CP, Dharmawardhane S.
    Transl Oncol; 2024 Jun 27; 44():101928. PubMed ID: 38489873
    [Abstract] [Full Text] [Related]

  • 18. Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells.
    Azios NG, Krishnamoorthy L, Harris M, Cubano LA, Cammer M, Dharmawardhane SF.
    Neoplasia; 2007 Feb 27; 9(2):147-58. PubMed ID: 17356711
    [Abstract] [Full Text] [Related]

  • 19. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases.
    Oprea TI, Sklar LA, Agola JO, Guo Y, Silberberg M, Roxby J, Vestling A, Romero E, Surviladze Z, Murray-Krezan C, Waller A, Ursu O, Hudson LG, Wandinger-Ness A.
    PLoS One; 2015 Feb 27; 10(11):e0142182. PubMed ID: 26558612
    [Abstract] [Full Text] [Related]

  • 20. Role of Rac1/WAVE2 Signaling in Mediating the Inhibitory Effects of γ-Tocotrienol on Mammary Cancer Cell Migration and Invasion.
    Algayadh IG, Dronamraju V, Sylvester PW.
    Biol Pharm Bull; 2016 Feb 27; 39(12):1974-1982. PubMed ID: 27904039
    [Abstract] [Full Text] [Related]

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