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Journal Abstract Search

619 related items for PubMed ID: 28560482

  • 1. Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5.
    Bian Y, Feng Z, Yang P, Xie XQ.
    AAPS J; 2017 Jul; 19(4):1235-1248. PubMed ID: 28560482
    [Abstract] [Full Text] [Related]

  • 2. Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity.
    Anighoro A, Graziani D, Bettinelli I, Cilia A, De Toma C, Longhi M, Mangiarotti F, Menegon S, Pirona L, Poggesi E, Riva C, Rastelli G.
    Bioorg Med Chem; 2015 Jul 01; 23(13):3040-58. PubMed ID: 26014480
    [Abstract] [Full Text] [Related]

  • 3. Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding.
    Butkiewicz M, Rodriguez AL, Rainey SE, Wieting J, Luscombe VB, Stauffer SR, Lindsley CW, Conn PJ, Meiler J.
    ACS Chem Neurosci; 2019 Aug 21; 10(8):3427-3436. PubMed ID: 31132237
    [Abstract] [Full Text] [Related]

  • 4. Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5.
    Kampen S, Rodríguez D, Jørgensen M, Kruszyk-Kujawa M, Huang X, Collins M, Boyle N, Maurel D, Rudling A, Lebon G, Carlsson J.
    ACS Chem Biol; 2022 Oct 21; 17(10):2744-2752. PubMed ID: 36149353
    [Abstract] [Full Text] [Related]

  • 5. 7TM X-ray structures for class C GPCRs as new drug-discovery tools. 1. mGluR5.
    Topiol S, Sabio M.
    Bioorg Med Chem Lett; 2016 Jan 15; 26(2):484-494. PubMed ID: 26706173
    [Abstract] [Full Text] [Related]

  • 6. Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.
    Christopher JA, Orgován Z, Congreve M, Doré AS, Errey JC, Marshall FH, Mason JS, Okrasa K, Rucktooa P, Serrano-Vega MJ, Ferenczy GG, Keserű GM.
    J Med Chem; 2019 Jan 10; 62(1):207-222. PubMed ID: 29455526
    [Abstract] [Full Text] [Related]

  • 7. The role of water and protein flexibility in the structure-based virtual screening of allosteric GPCR modulators: an mGlu5 receptor case study.
    Orgován Z, Ferenczy GG, Keserű GM.
    J Comput Aided Mol Des; 2019 Sep 10; 33(9):787-797. PubMed ID: 31542869
    [Abstract] [Full Text] [Related]

  • 8. Subtype-selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptors.
    Fu TT, Tu G, Ping M, Zheng GX, Yang FY, Yang JY, Zhang Y, Yao XJ, Xue WW, Zhu F.
    Acta Pharmacol Sin; 2021 Aug 10; 42(8):1354-1367. PubMed ID: 33122823
    [Abstract] [Full Text] [Related]

  • 9. Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators.
    Bennett KA, Christopher JA, Tehan BG.
    Adv Pharmacol; 2020 Aug 10; 88():35-58. PubMed ID: 32416871
    [Abstract] [Full Text] [Related]

  • 10. "Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands.
    Hellyer SD, Albold S, Wang T, Chen ANY, May LT, Leach K, Gregory KJ.
    Mol Pharmacol; 2018 May 10; 93(5):504-514. PubMed ID: 29514854
    [Abstract] [Full Text] [Related]

  • 11. Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors.
    Feng Z, Hu G, Ma S, Xie XQ.
    AAPS J; 2015 Sep 10; 17(5):1080-95. PubMed ID: 25940084
    [Abstract] [Full Text] [Related]

  • 12. Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.
    Gregory KJ, Nguyen ED, Malosh C, Mendenhall JL, Zic JZ, Bates BS, Noetzel MJ, Squire EF, Turner EM, Rook JM, Emmitte KA, Stauffer SR, Lindsley CW, Meiler J, Conn PJ.
    ACS Chem Neurosci; 2014 Apr 16; 5(4):282-95. PubMed ID: 24528109
    [Abstract] [Full Text] [Related]

  • 13. Exploring the Binding Mechanism of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators in Clinical Trials by Molecular Dynamics Simulations.
    Fu T, Zheng G, Tu G, Yang F, Chen Y, Yao X, Li X, Xue W, Zhu F.
    ACS Chem Neurosci; 2018 Jun 20; 9(6):1492-1502. PubMed ID: 29522307
    [Abstract] [Full Text] [Related]

  • 14. Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators.
    Gregory KJ, Velagaleti R, Thal DM, Brady RM, Christopoulos A, Conn PJ, Lapinsky DJ.
    ACS Chem Biol; 2016 Jul 15; 11(7):1870-9. PubMed ID: 27115427
    [Abstract] [Full Text] [Related]

  • 15. SAR studies on mGlu5 receptor positive allosteric modulators (2003- 2013).
    Hao J, Xiong H.
    Curr Top Med Chem; 2014 Jul 15; 14(15):1789-841. PubMed ID: 25176124
    [Abstract] [Full Text] [Related]

  • 16. Biased agonism and allosteric modulation of metabotropic glutamate receptor 5.
    Trinh PNH, May LT, Leach K, Gregory KJ.
    Clin Sci (Lond); 2018 Nov 15; 132(21):2323-2338. PubMed ID: 30389826
    [Abstract] [Full Text] [Related]

  • 17. Fragment-Based Approaches for Allosteric Metabotropic Glutamate Receptor (mGluR) Modulators.
    Orgován Z, Ferenczy GG, Keserű GM.
    Curr Top Med Chem; 2019 Nov 15; 19(19):1768-1781. PubMed ID: 31393248
    [Abstract] [Full Text] [Related]

  • 18. Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site.
    Hellyer SD, Sengmany K, Keller AN, Christopoulos A, Leach K, Gregory KJ.
    Biochem Pharmacol; 2020 Jul 15; 177():114013. PubMed ID: 32389635
    [Abstract] [Full Text] [Related]

  • 19. Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery.
    Sengmany K, Singh J, Stewart GD, Conn PJ, Christopoulos A, Gregory KJ.
    Neuropharmacology; 2017 Mar 15; 115():60-72. PubMed ID: 27392634
    [Abstract] [Full Text] [Related]

  • 20. Scaffold hopping approach towards various AFQ-056 analogs as potent metabotropic glutamate receptor 5 negative allosteric modulators.
    Kubas H, Meyer U, Hechenberger M, Klein KU, Plitt P, Zemribo R, Spexgoor HW, van Assema SG, Abel U.
    Bioorg Med Chem Lett; 2013 Dec 01; 23(23):6370-6. PubMed ID: 24125886
    [Abstract] [Full Text] [Related]

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