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Journal Abstract Search

463 related items for PubMed ID: 28581721

  • 1. A Fusion Protein of the p53 Transaction Domain and the p53-Binding Domain of the Oncoprotein MdmX as an Efficient System for High-Throughput Screening of MdmX Inhibitors.
    Chen R, Zhou J, Qin L, Chen Y, Huang Y, Liu H, Su Z.
    Biochemistry; 2017 Jun 27; 56(25):3273-3282. PubMed ID: 28581721
    [Abstract] [Full Text] [Related]

  • 2. Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.
    Lemos A, Leão M, Soares J, Palmeira A, Pinto M, Saraiva L, Sousa ME.
    Med Res Rev; 2016 Sep 27; 36(5):789-844. PubMed ID: 27302609
    [Abstract] [Full Text] [Related]

  • 3. A site-directed mutagenesis study of the MdmX RING domain.
    Egorova O, Mis M, Sheng Y.
    Biochem Biophys Res Commun; 2014 May 16; 447(4):696-701. PubMed ID: 24755078
    [Abstract] [Full Text] [Related]

  • 4. Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidic inhibitors.
    Noguchi T, Oishi S, Honda K, Kondoh Y, Saito T, Kubo T, Kaneda M, Ohno H, Osada H, Fujii N.
    Bioorg Med Chem Lett; 2013 Jul 01; 23(13):3802-5. PubMed ID: 23726030
    [Abstract] [Full Text] [Related]

  • 5. Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
    Pazgier M, Liu M, Zou G, Yuan W, Li C, Li C, Li J, Monbo J, Zella D, Tarasov SG, Lu W.
    Proc Natl Acad Sci U S A; 2009 Mar 24; 106(12):4665-70. PubMed ID: 19255450
    [Abstract] [Full Text] [Related]

  • 6. Effect of the Flexible Regions of the Oncoprotein Mouse Double Minute X on Inhibitor Binding Affinity.
    Qin L, Liu H, Chen R, Zhou J, Cheng X, Chen Y, Huang Y, Su Z.
    Biochemistry; 2017 Nov 07; 56(44):5943-5954. PubMed ID: 29023092
    [Abstract] [Full Text] [Related]

  • 7. Efficient reactivation of p53 in cancer cells by a dual MdmX/Mdm2 inhibitor.
    Qin L, Yang F, Zhou C, Chen Y, Zhang H, Su Z.
    J Am Chem Soc; 2014 Dec 31; 136(52):18023-33. PubMed ID: 25453499
    [Abstract] [Full Text] [Related]

  • 8. Molecular basis for the inhibition of p53 by Mdmx.
    Popowicz GM, Czarna A, Rothweiler U, Szwagierczak A, Krajewski M, Weber L, Holak TA.
    Cell Cycle; 2007 Oct 01; 6(19):2386-92. PubMed ID: 17938582
    [Abstract] [Full Text] [Related]

  • 9. Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.
    Popowicz GM, Czarna A, Wolf S, Wang K, Wang W, Dömling A, Holak TA.
    Cell Cycle; 2010 Mar 15; 9(6):1104-11. PubMed ID: 20237429
    [Abstract] [Full Text] [Related]

  • 10. Autoinhibition of MDMX by intramolecular p53 mimicry.
    Chen L, Borcherds W, Wu S, Becker A, Schonbrunn E, Daughdrill GW, Chen J.
    Proc Natl Acad Sci U S A; 2015 Apr 14; 112(15):4624-9. PubMed ID: 25825738
    [Abstract] [Full Text] [Related]

  • 11. Discovery of novel dual inhibitors against Mdm2 and Mdmx proteins by in silico approaches and binding assay.
    Golestanian S, Sharifi A, Popowicz GM, Azizian H, Foroumadi A, Szwagierczak A, Holak TA, Amanlou M.
    Life Sci; 2016 Jan 15; 145():240-6. PubMed ID: 26746660
    [Abstract] [Full Text] [Related]

  • 12. A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins.
    Soares J, Raimundo L, Pereira NA, dos Santos DJ, Pérez M, Queiroz G, Leão M, Santos MM, Saraiva L.
    Pharmacol Res; 2015 Jan 15; 95-96():42-52. PubMed ID: 25814188
    [Abstract] [Full Text] [Related]

  • 13. Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase.
    Okamoto K, Taya Y, Nakagama H.
    FEBS Lett; 2009 Sep 03; 583(17):2710-4. PubMed ID: 19619542
    [Abstract] [Full Text] [Related]

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  • 15. Designing dual inhibitors of Mdm2/MdmX: Unexpected coupling of water with gatekeeper Y100/99.
    Lee XA, Verma C, Sim AYL.
    Proteins; 2017 Aug 03; 85(8):1493-1506. PubMed ID: 28425639
    [Abstract] [Full Text] [Related]

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  • 17. Induction of p53 expression and apoptosis by a recombinant dual-target MDM2/MDMX inhibitory protein in wild-type p53 breast cancer cells.
    Geng QQ, Dong DF, Chen NZ, Wu YY, Li EX, Wang J, Wang SM.
    Int J Oncol; 2013 Dec 03; 43(6):1935-42. PubMed ID: 24126697
    [Abstract] [Full Text] [Related]

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  • 19. Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX.
    Hu B, Gilkes DM, Chen J.
    Cancer Res; 2007 Sep 15; 67(18):8810-7. PubMed ID: 17875722
    [Abstract] [Full Text] [Related]

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