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Journal Abstract Search

184 related items for PubMed ID: 2858383

  • 1. Studies on the biotransformation in the perfused rat liver of 2-n-propyl-4-pentenoic acid, a metabolite of the antiepileptic drug valproic acid. Evidence for the formation of chemically reactive intermediates.
    Rettenmeier AW, Prickett KS, Gordon WP, Bjorge SM, Chang SL, Levy RH, Baillie TA.
    Drug Metab Dispos; 1985; 13(1):81-96. PubMed ID: 2858383
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  • 2. Biotransformation and pharmacokinetics in the rhesus monkey of 2-n-propyl-4-pentenoic acid, a toxic metabolite of valproic acid.
    Rettenmeier AW, Gordon WP, Prickett KS, Levy RH, Baillie TA.
    Drug Metab Dispos; 1986; 14(4):454-64. PubMed ID: 2873993
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  • 3. Metabolic fate of valproic acid in the rhesus monkey. Formation of a toxic metabolite, 2-n-propyl-4-pentenoic acid.
    Rettenmeier AW, Gordon WP, Prickett KS, Levy RH, Lockard JS, Thummel KE, Baillie TA.
    Drug Metab Dispos; 1986; 14(4):443-53. PubMed ID: 2873992
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  • 4. Cytochrome P-450-mediated dehydrogenation of 2-n-propyl-2(E)-pentenoic acid, a pharmacologically-active metabolite of valproic acid, in rat liver microsomal preparations.
    Kassahun K, Baillie TA.
    Drug Metab Dispos; 1993; 21(2):242-8. PubMed ID: 8097692
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  • 6. Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans.
    Kassahun K, Farrell K, Abbott F.
    Drug Metab Dispos; 1991; 19(2):525-35. PubMed ID: 1676665
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  • 7. In vivo formation of the thiol conjugates of reactive metabolites of 4-ene VPA and its analog 4-pentenoic acid.
    Kassahun K, Abbott F.
    Drug Metab Dispos; 1993; 21(6):1098-106. PubMed ID: 7905390
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  • 8. Enantiotopic differentiation during the biotransformation of valproic acid to the hepatotoxic olefin 2-n-propyl-4-pentenoic acid.
    Porubek DJ, Barnes H, Meier GP, Theodore LJ, Baillie TA.
    Chem Res Toxicol; 1989; 2(1):35-40. PubMed ID: 2519229
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  • 9. Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and -independent processes.
    Kassahun K, Hu P, Grillo MP, Davis MR, Jin L, Baillie TA.
    Chem Biol Interact; 1994 Mar; 90(3):253-75. PubMed ID: 8168173
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  • 10. Cytochrome P-450--catalyzed formation of delta 4-VPA, a toxic metabolite of valproic acid.
    Rettie AE, Rettenmeier AW, Howald WN, Baillie TA.
    Science; 1987 Feb 20; 235(4791):890-3. PubMed ID: 3101178
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  • 13. Studies on the beta-oxidation of valproic acid in rat liver mitochondrial preparations.
    Bjorge SM, Baillie TA.
    Drug Metab Dispos; 1991 Feb 20; 19(4):823-9. PubMed ID: 1680661
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  • 14. Metabolism of unsaturated derivatives of valproic acid in rat liver microsomes and destruction of cytochrome P-450.
    Prickett KS, Baillie TA.
    Drug Metab Dispos; 1986 Feb 20; 14(2):221-9. PubMed ID: 2870898
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  • 15. Valproic acid and active unsaturated metabolite (2-en): transfer to mouse liver following human therapeutic doses.
    Nau H, Loscher W.
    Biopharm Drug Dispos; 1985 Feb 20; 6(1):1-8. PubMed ID: 3921077
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  • 16. Characterization of thiol-conjugated metabolites of 2-propylpent-4-enoic acid (4-ene VPA), a toxic metabolite of valproic acid, by electrospray tandem mass spectrometry.
    Tang W, Abbott FS.
    J Mass Spectrom; 1996 Aug 20; 31(8):926-36. PubMed ID: 8799319
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  • 19. Conjugation of glutathione with a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, catalyzed by rat hepatic glutathione-S-transferases.
    Tang W, Borel AG, Abbott FS.
    Drug Metab Dispos; 1996 Apr 20; 24(4):436-46. PubMed ID: 8801059
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  • 20. Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates.
    Tang W, Abbott FS.
    Chem Res Toxicol; 1996 Mar 20; 9(2):517-26. PubMed ID: 8839057
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