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252 related items for PubMed ID: 28600229

  • 1. The structural basis of alpha-tropomyosin linked (Asp230Asn) familial dilated cardiomyopathy.
    Lynn ML, Tal Grinspan L, Holeman TA, Jimenez J, Strom J, Tardiff JC.
    J Mol Cell Cardiol; 2017 Jul; 108():127-137. PubMed ID: 28600229
    [Abstract] [Full Text] [Related]

  • 2. Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity.
    Rajan S, Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, Urboniene D, Arteaga GM, Wolska BM, Solaro RJ, Liggett SB, Wieczorek DF.
    Circ Res; 2007 Jul 20; 101(2):205-14. PubMed ID: 17556658
    [Abstract] [Full Text] [Related]

  • 3. Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap.
    McConnell M, Tal Grinspan L, Williams MR, Lynn ML, Schwartz BA, Fass OZ, Schwartz SD, Tardiff JC.
    Biochemistry; 2017 Jul 05; 56(26):3403-3413. PubMed ID: 28603979
    [Abstract] [Full Text] [Related]

  • 4. Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity.
    Memo M, Leung MC, Ward DG, dos Remedios C, Morimoto S, Zhang L, Ravenscroft G, McNamara E, Nowak KJ, Marston SB, Messer AE.
    Cardiovasc Res; 2013 Jul 01; 99(1):65-73. PubMed ID: 23539503
    [Abstract] [Full Text] [Related]

  • 5. Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts.
    Powers JD, Kooiker KB, Mason AB, Teitgen AE, Flint GV, Tardiff JC, Schwartz SD, McCulloch AD, Regnier M, Davis J, Moussavi-Harami F.
    JCI Insight; 2020 Oct 15; 5(20):. PubMed ID: 32931484
    [Abstract] [Full Text] [Related]

  • 6. Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.
    Karam CN, Warren CM, Rajan S, de Tombe PP, Wieczorek DF, Solaro RJ.
    J Muscle Res Cell Motil; 2011 Mar 15; 31(5-6):315-22. PubMed ID: 21221740
    [Abstract] [Full Text] [Related]

  • 7. Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy.
    Lakdawala NK, Dellefave L, Redwood CS, Sparks E, Cirino AL, Depalma S, Colan SD, Funke B, Zimmerman RS, Robinson P, Watkins H, Seidman CE, Seidman JG, McNally EM, Ho CY.
    J Am Coll Cardiol; 2010 Jan 26; 55(4):320-9. PubMed ID: 20117437
    [Abstract] [Full Text] [Related]

  • 8. The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments.
    Mirza M, Robinson P, Kremneva E, Copeland O, Nikolaeva O, Watkins H, Levitsky D, Redwood C, El-Mezgueldi M, Marston S.
    J Biol Chem; 2007 May 04; 282(18):13487-97. PubMed ID: 17360712
    [Abstract] [Full Text] [Related]

  • 9. Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L.
    Yar S, Chowdhury SAK, Davis RT, Kobayashi M, Monasky MM, Rajan S, Wolska BM, Gaponenko V, Kobayashi T, Wieczorek DF, Solaro RJ.
    J Biol Chem; 2013 Jun 07; 288(23):16235-16246. PubMed ID: 23609439
    [Abstract] [Full Text] [Related]

  • 10. A novel alpha-tropomyosin mutation associates with dilated and non-compaction cardiomyopathy and diminishes actin binding.
    van de Meerakker JB, Christiaans I, Barnett P, Lekanne Deprez RH, Ilgun A, Mook OR, Mannens MM, Lam J, Wilde AA, Moorman AF, Postma AV.
    Biochim Biophys Acta; 2013 Apr 07; 1833(4):833-9. PubMed ID: 23147248
    [Abstract] [Full Text] [Related]

  • 11. HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments.
    Farman GP, Rynkiewicz MJ, Orzechowski M, Lehman W, Moore JR.
    Arch Biochem Biophys; 2018 Jun 01; 647():84-92. PubMed ID: 29626422
    [Abstract] [Full Text] [Related]

  • 12. Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments.
    Robinson P, Griffiths PJ, Watkins H, Redwood CS.
    Circ Res; 2007 Dec 07; 101(12):1266-73. PubMed ID: 17932326
    [Abstract] [Full Text] [Related]

  • 13. Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca2+, and activate NFAT and Akt signaling.
    Robinson P, Sparrow AJ, Patel S, Malinowska M, Reilly SN, Zhang YH, Casadei B, Watkins H, Redwood C.
    Am J Physiol Heart Circ Physiol; 2020 Aug 01; 319(2):H306-H319. PubMed ID: 32618513
    [Abstract] [Full Text] [Related]

  • 14. Long-Term Biased β-Arrestin Signaling Improves Cardiac Structure and Function in Dilated Cardiomyopathy.
    Ryba DM, Li J, Cowan CL, Russell B, Wolska BM, Solaro RJ.
    Circulation; 2017 Mar 14; 135(11):1056-1070. PubMed ID: 28104714
    [Abstract] [Full Text] [Related]

  • 15. Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform.
    Rajan S, Jagatheesan G, Karam CN, Alves ML, Bodi I, Schwartz A, Bulcao CF, D'Souza KM, Akhter SA, Boivin GP, Dube DK, Petrashevskaya N, Herr AB, Hullin R, Liggett SB, Wolska BM, Solaro RJ, Wieczorek DF.
    Circulation; 2010 Jan 26; 121(3):410-8. PubMed ID: 20065163
    [Abstract] [Full Text] [Related]

  • 16. The Relaxation Properties of Myofibrils Are Compromised by Amino Acids that Stabilize α-Tropomyosin.
    Scellini B, Piroddi N, Matyushenko AM, Levitsky DI, Poggesi C, Lehrer SS, Tesi C.
    Biophys J; 2017 Jan 24; 112(2):376-387. PubMed ID: 28122223
    [Abstract] [Full Text] [Related]

  • 17. Investigation of a transgenic mouse model of familial dilated cardiomyopathy.
    Song W, Dyer E, Stuckey D, Leung MC, Memo M, Mansfield C, Ferenczi M, Liu K, Redwood C, Nowak K, Harding S, Clarke K, Wells D, Marston S.
    J Mol Cell Cardiol; 2010 Sep 24; 49(3):380-9. PubMed ID: 20600154
    [Abstract] [Full Text] [Related]

  • 18. Use of 2-D DIGE analysis reveals altered phosphorylation in a tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy.
    Warren CM, Arteaga GM, Rajan S, Ahmed RP, Wieczorek DF, Solaro RJ.
    Proteomics; 2008 Jan 24; 8(1):100-5. PubMed ID: 18095372
    [Abstract] [Full Text] [Related]

  • 19. M8R tropomyosin mutation disrupts actin binding and filament regulation: The beginning affects the middle and end.
    Racca AW, Rynkiewicz MJ, LaFave N, Ghosh A, Lehman W, Moore JR.
    J Biol Chem; 2020 Dec 11; 295(50):17128-17137. PubMed ID: 33020181
    [Abstract] [Full Text] [Related]

  • 20. Alpha-tropomyosin mutations in inherited cardiomyopathies.
    Redwood C, Robinson P.
    J Muscle Res Cell Motil; 2013 Aug 11; 34(3-4):285-94. PubMed ID: 24005378
    [Abstract] [Full Text] [Related]

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