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370 related items for PubMed ID: 28600982

  • 1. Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration.
    Ferrington DA, Ebeling MC, Kapphahn RJ, Terluk MR, Fisher CR, Polanco JR, Roehrich H, Leary MM, Geng Z, Dutton JR, Montezuma SR.
    Redox Biol; 2017 Oct; 13():255-265. PubMed ID: 28600982
    [Abstract] [Full Text] [Related]

  • 2. Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration.
    Golestaneh N, Chu Y, Cheng SK, Cao H, Poliakov E, Berinstein DM.
    J Transl Med; 2016 Dec 20; 14(1):344. PubMed ID: 27998274
    [Abstract] [Full Text] [Related]

  • 3. Improving retinal mitochondrial function as a treatment for age-related macular degeneration.
    Ebeling MC, Polanco JR, Qu J, Tu C, Montezuma SR, Ferrington DA.
    Redox Biol; 2020 Jul 20; 34():101552. PubMed ID: 32446621
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  • 5. Mitochondrial damage and clearance in retinal pigment epithelial cells.
    Gurubaran IS.
    Acta Ophthalmol; 2024 Mar 20; 102 Suppl 282():3-53. PubMed ID: 38467968
    [Abstract] [Full Text] [Related]

  • 6. Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors.
    Brown EE, DeWeerd AJ, Ildefonso CJ, Lewin AS, Ash JD.
    Redox Biol; 2019 Jun 20; 24():101201. PubMed ID: 31039480
    [Abstract] [Full Text] [Related]

  • 7. Dissecting Regulators of Aging and Age-Related Macular Degeneration in the Retinal Pigment Epithelium.
    Karunadharma PP, Kapphahn RJ, Stahl MR, Olsen TW, Ferrington DA.
    Oxid Med Cell Longev; 2022 Jun 20; 2022():6009787. PubMed ID: 36439688
    [Abstract] [Full Text] [Related]

  • 8. Pgc-1α repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice.
    Zhang M, Chu Y, Mowery J, Konkel B, Galli S, Theos AC, Golestaneh N.
    Dis Model Mech; 2018 Aug 16; 11(9):. PubMed ID: 29925537
    [Abstract] [Full Text] [Related]

  • 9. PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis.
    Kaarniranta K, Kajdanek J, Morawiec J, Pawlowska E, Blasiak J.
    Int J Mol Sci; 2018 Aug 07; 19(8):. PubMed ID: 30087287
    [Abstract] [Full Text] [Related]

  • 10. Oxidative stress damage circumscribed to the central temporal retinal pigment epithelium in early experimental non-exudative age-related macular degeneration.
    Dieguez HH, Romeo HE, Alaimo A, González Fleitas MF, Aranda ML, Rosenstein RE, Dorfman D.
    Free Radic Biol Med; 2019 Feb 01; 131():72-80. PubMed ID: 30502459
    [Abstract] [Full Text] [Related]

  • 11. VEGF and ELAVL1/HuR protein levels are increased in dry and wet AMD patients. A new tile in the pathophysiologic mechanisms underlying RPE degeneration?
    Bresciani G, Manai F, Felszeghy S, Smedowski A, Kaarniranta K, Amadio M.
    Pharmacol Res; 2024 Oct 01; 208():107380. PubMed ID: 39216841
    [Abstract] [Full Text] [Related]

  • 12. PGC-1α Induces Human RPE Oxidative Metabolism and Antioxidant Capacity.
    Iacovelli J, Rowe GC, Khadka A, Diaz-Aguilar D, Spencer C, Arany Z, Saint-Geniez M.
    Invest Ophthalmol Vis Sci; 2016 Mar 01; 57(3):1038-51. PubMed ID: 26962700
    [Abstract] [Full Text] [Related]

  • 13. Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration.
    Golestaneh N, Chu Y, Xiao YY, Stoleru GL, Theos AC.
    Cell Death Dis; 2017 Jan 05; 8(1):e2537. PubMed ID: 28055007
    [Abstract] [Full Text] [Related]

  • 14. PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in retinal pigment epithelium.
    Zhou S, Taskintuna K, Hum J, Gulati J, Olaya S, Steinman J, Golestaneh N.
    Cell Death Dis; 2024 Jun 01; 15(6):385. PubMed ID: 38824126
    [Abstract] [Full Text] [Related]

  • 15. Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration.
    Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K.
    Redox Biol; 2019 Jan 01; 20():1-12. PubMed ID: 30253279
    [Abstract] [Full Text] [Related]

  • 16. Modeling of mitochondrial bioenergetics and autophagy impairment in MELAS-mutant iPSC-derived retinal pigment epithelial cells.
    Bhattacharya S, Yin J, Huo W, Chaum E.
    Stem Cell Res Ther; 2022 Jun 17; 13(1):260. PubMed ID: 35715869
    [Abstract] [Full Text] [Related]

  • 17. Oxidative Stress-Induced Pentraxin 3 Expression Human Retinal Pigment Epithelial Cells is Involved in the Pathogenesis of Age-Related Macular Degeneration.
    Hwang N, Kwon MY, Woo JM, Chung SW.
    Int J Mol Sci; 2019 Nov 29; 20(23):. PubMed ID: 31795454
    [Abstract] [Full Text] [Related]

  • 18. Investigating mitochondrial fission, fusion, and autophagy in retinal pigment epithelium from donors with age-related macular degeneration.
    Fisher CR, Shaaeli AA, Ebeling MC, Montezuma SR, Ferrington DA.
    Sci Rep; 2022 Dec 16; 12(1):21725. PubMed ID: 36526679
    [Abstract] [Full Text] [Related]

  • 19. DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE).
    Shadrach KG, Rayborn ME, Hollyfield JG, Bonilha VL.
    PLoS One; 2013 Dec 16; 8(7):e67983. PubMed ID: 23844142
    [Abstract] [Full Text] [Related]

  • 20. Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model.
    Sridevi Gurubaran I, Viiri J, Koskela A, Hyttinen JMT, Paterno JJ, Kis G, Antal M, Urtti A, Kauppinen A, Felszeghy S, Kaarniranta K.
    Int J Mol Sci; 2020 Mar 13; 21(6):. PubMed ID: 32183173
    [Abstract] [Full Text] [Related]

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