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Journal Abstract Search

275 related items for PubMed ID: 28603988

  • 1. New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
    Liu HY, Chen AC, Yin QK, Li Z, Huang SM, Du G, He JH, Zan LP, Wang SK, Xu YH, Tan JH, Ou TM, Li D, Gu LQ, Huang ZS.
    J Med Chem; 2017 Jul 13; 60(13):5438-5454. PubMed ID: 28603988
    [Abstract] [Full Text] [Related]

  • 2. Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter.
    Boddupally PV, Hahn S, Beman C, De B, Brooks TA, Gokhale V, Hurley LH.
    J Med Chem; 2012 Jul 12; 55(13):6076-86. PubMed ID: 22691117
    [Abstract] [Full Text] [Related]

  • 3. Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex.
    Shan C, Yan JW, Wang YQ, Che T, Huang ZL, Chen AC, Yao PF, Tan JH, Li D, Ou TM, Gu LQ, Huang ZS.
    J Med Chem; 2017 Feb 23; 60(4):1292-1308. PubMed ID: 28128954
    [Abstract] [Full Text] [Related]

  • 4. Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction.
    Wang YQ, Huang ZL, Chen SB, Wang CX, Shan C, Yin QK, Ou TM, Li D, Gu LQ, Tan JH, Huang ZS.
    J Med Chem; 2017 Aug 24; 60(16):6924-6941. PubMed ID: 28714689
    [Abstract] [Full Text] [Related]

  • 5. Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives.
    Ou TM, Lu YJ, Zhang C, Huang ZS, Wang XD, Tan JH, Chen Y, Ma DL, Wong KY, Tang JC, Chan AS, Gu LQ.
    J Med Chem; 2007 Apr 05; 50(7):1465-74. PubMed ID: 17346034
    [Abstract] [Full Text] [Related]

  • 6. Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry.
    Zeng DY, Kuang GT, Wang SK, Peng W, Lin SL, Zhang Q, Su XX, Hu MH, Wang H, Tan JH, Huang ZS, Gu LQ, Ou TM.
    J Med Chem; 2017 Jul 13; 60(13):5407-5423. PubMed ID: 28514170
    [Abstract] [Full Text] [Related]

  • 7. Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex.
    Hu MH, Wang YQ, Yu ZY, Hu LN, Ou TM, Chen SB, Huang ZS, Tan JH.
    J Med Chem; 2018 Mar 22; 61(6):2447-2459. PubMed ID: 29474069
    [Abstract] [Full Text] [Related]

  • 8. Cryptolepine and aromathecin based mimics as potent G-quadruplex-binding, DNA-cleavage and anticancer agents: Design, synthesis and DNA targeting-induced apoptosis.
    Yuan JM, Wei K, Zhang GH, Chen NY, Wei XW, Pan CX, Mo DL, Su GF.
    Eur J Med Chem; 2019 May 01; 169():144-158. PubMed ID: 30875505
    [Abstract] [Full Text] [Related]

  • 9. Design, Synthesis, and Evaluation of Novel p-(Methylthio)styryl Substituted Quindoline Derivatives as Neuroblastoma RAS (NRAS) Repressors via Specific Stabilizing the RNA G-Quadruplex.
    Peng W, Sun ZY, Zhang Q, Cheng SQ, Wang SK, Wang XN, Kuang GT, Su XX, Tan JH, Huang ZS, Ou TM.
    J Med Chem; 2018 Aug 09; 61(15):6629-6646. PubMed ID: 29799749
    [Abstract] [Full Text] [Related]

  • 10. A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex.
    Wu TY, Huang Q, Huang ZS, Hu MH, Tan JH.
    Bioorg Chem; 2020 Jun 09; 99():103866. PubMed ID: 32330737
    [Abstract] [Full Text] [Related]

  • 11. Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives.
    Wang XD, Ou TM, Lu YJ, Li Z, Xu Z, Xi C, Tan JH, Huang SL, An LK, Li D, Gu LQ, Huang ZS.
    J Med Chem; 2010 Jun 10; 53(11):4390-8. PubMed ID: 20481493
    [Abstract] [Full Text] [Related]

  • 12. Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design.
    Dai J, Carver M, Hurley LH, Yang D.
    J Am Chem Soc; 2011 Nov 09; 133(44):17673-80. PubMed ID: 21967482
    [Abstract] [Full Text] [Related]

  • 13. Quinolino-benzo-[5, 6]-dihydroisoquindolium compounds derived from berberine: a new class of highly selective ligands for G-quadruplex DNA in c-myc oncogene.
    Ma Y, Ou TM, Tan JH, Hou JQ, Huang SL, Gu LQ, Huang ZS.
    Eur J Med Chem; 2011 May 09; 46(5):1906-13. PubMed ID: 21392861
    [Abstract] [Full Text] [Related]

  • 14. Syntheses and Evaluation of New Bisacridine Derivatives for Dual Binding of G-Quadruplex and i-Motif in Regulating Oncogene c-myc Expression.
    Kuang G, Zhang M, Kang S, Hu D, Li X, Wei Z, Gong X, An LK, Huang ZS, Shu B, Li D.
    J Med Chem; 2020 Sep 10; 63(17):9136-9153. PubMed ID: 32787078
    [Abstract] [Full Text] [Related]

  • 15. 5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation.
    Lu YJ, Ou TM, Tan JH, Hou JQ, Shao WY, Peng D, Sun N, Wang XD, Wu WB, Bu XZ, Huang ZS, Ma DL, Wong KY, Gu LQ.
    J Med Chem; 2008 Oct 23; 51(20):6381-92. PubMed ID: 18821749
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
    Ou TM, Lin J, Lu YJ, Hou JQ, Tan JH, Chen SH, Li Z, Li YP, Li D, Gu LQ, Huang ZS.
    J Med Chem; 2011 Aug 25; 54(16):5671-9. PubMed ID: 21774525
    [Abstract] [Full Text] [Related]

  • 17. Different cytotoxicities and cellular localizations of novel quindoline derivatives with or without boronic acid modifications in cancer cells.
    Yin R, Zhang M, Hao C, Wang W, Qiu P, Wan S, Zhang L, Jiang T.
    Chem Commun (Camb); 2013 Oct 04; 49(76):8516-8. PubMed ID: 23942773
    [Abstract] [Full Text] [Related]

  • 18. The G-quadruplex ligand, SYUIQ-FM05, targets proto-oncogene c-kit transcription and induces apoptosis in K562 cells.
    Shen FH, Jin J, Li J, Wang Y, Zhu SH, Lu YJ, Ou TM, Huang ZS, Huang M, Huang ZY.
    Pharm Biol; 2013 Apr 04; 51(4):447-54. PubMed ID: 23363047
    [Abstract] [Full Text] [Related]

  • 19. Design, synthesis, and evaluation of novel quindoline derivatives with fork-shaped side chains as RNA G-quadruplex stabilizers for repressing oncogene NRAS translation.
    Sun JW, Zou J, Zheng Y, Yuan H, Xie YZ, Wang XN, Ou TM.
    Eur J Med Chem; 2024 May 05; 271():116406. PubMed ID: 38688064
    [Abstract] [Full Text] [Related]

  • 20. A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down-regulates c-MYC expression in human cancer cells.
    Nagesh N, Raju G, Srinivas R, Ramesh P, Reddy MD, Reddy ChR.
    Biochim Biophys Acta; 2015 Jan 05; 1850(1):129-40. PubMed ID: 25452213
    [Abstract] [Full Text] [Related]

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