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Journal Abstract Search

615 related items for PubMed ID: 28614296

  • 1. Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.
    Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ.
    Nature; 2017 Jun 22; 546(7659):528-532. PubMed ID: 28614296
    [Abstract] [Full Text] [Related]

  • 2. Human Urine Decreases Function and Expression of Type 1 Pili in Uropathogenic Escherichia coli.
    Greene SE, Hibbing ME, Janetka J, Chen SL, Hultgren SJ.
    mBio; 2015 Jun 30; 6(4):e00820. PubMed ID: 26126855
    [Abstract] [Full Text] [Related]

  • 3. Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.
    Guiton PS, Cusumano CK, Kline KA, Dodson KW, Han Z, Janetka JW, Henderson JP, Caparon MG, Hultgren SJ.
    Antimicrob Agents Chemother; 2012 Sep 30; 56(9):4738-45. PubMed ID: 22733070
    [Abstract] [Full Text] [Related]

  • 4. Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn's disease.
    Mydock-McGrane LK, Hannan TJ, Janetka JW.
    Expert Opin Drug Discov; 2017 Jul 30; 12(7):711-731. PubMed ID: 28506090
    [Abstract] [Full Text] [Related]

  • 5. Proposed dual antagonist approach for the prevention and treatment of urinary tract infections caused by uropathogenic Escherichia coli.
    Ribić R, Meštrović T, Neuberg M, Kozina G.
    Med Hypotheses; 2019 Mar 30; 124():17-20. PubMed ID: 30798908
    [Abstract] [Full Text] [Related]

  • 6. Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.
    Jarvis C, Han Z, Kalas V, Klein R, Pinkner JS, Ford B, Binkley J, Cusumano CK, Cusumano Z, Mydock-McGrane L, Hultgren SJ, Janetka JW.
    ChemMedChem; 2016 Feb 17; 11(4):367-73. PubMed ID: 26812660
    [Abstract] [Full Text] [Related]

  • 7. FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation.
    Klein T, Abgottspon D, Wittwer M, Rabbani S, Herold J, Jiang X, Kleeb S, Lüthi C, Scharenberg M, Bezençon J, Gubler E, Pang L, Smiesko M, Cutting B, Schwardt O, Ernst B.
    J Med Chem; 2010 Dec 23; 53(24):8627-41. PubMed ID: 21105658
    [Abstract] [Full Text] [Related]

  • 8. Development of Heptylmannoside-Based Glycoconjugate Antiadhesive Compounds against Adherent-Invasive Escherichia coli Bacteria Associated with Crohn's Disease.
    Sivignon A, Yan X, Alvarez Dorta D, Bonnet R, Bouckaert J, Fleury E, Bernard J, Gouin SG, Darfeuille-Michaud A, Barnich N.
    mBio; 2015 Nov 17; 6(6):e01298-15. PubMed ID: 26578673
    [Abstract] [Full Text] [Related]

  • 9. FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile.
    Kleeb S, Pang L, Mayer K, Eris D, Sigl A, Preston RC, Zihlmann P, Sharpe T, Jakob RP, Abgottspon D, Hutter AS, Scharenberg M, Jiang X, Navarra G, Rabbani S, Smiesko M, Lüdin N, Bezençon J, Schwardt O, Maier T, Ernst B.
    J Med Chem; 2015 Mar 12; 58(5):2221-39. PubMed ID: 25666045
    [Abstract] [Full Text] [Related]

  • 10. A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131.
    Totsika M, Kostakioti M, Hannan TJ, Upton M, Beatson SA, Janetka JW, Hultgren SJ, Schembri MA.
    J Infect Dis; 2013 Sep 12; 208(6):921-8. PubMed ID: 23737602
    [Abstract] [Full Text] [Related]

  • 11. Target Selectivity of FimH Antagonists.
    Scharenberg M, Schwardt O, Rabbani S, Ernst B.
    J Med Chem; 2012 Nov 26; 55(22):9810-6. PubMed ID: 23088608
    [Abstract] [Full Text] [Related]

  • 12. Luteolin decreases the attachment, invasion and cytotoxicity of UPEC in bladder epithelial cells and inhibits UPEC biofilm formation.
    Shen XF, Ren LB, Teng Y, Zheng S, Yang XL, Guo XJ, Wang XY, Sha KH, Li N, Xu GY, Tian HW, Wang XY, Liu XK, Li J, Huang N.
    Food Chem Toxicol; 2014 Oct 26; 72():204-11. PubMed ID: 25051393
    [Abstract] [Full Text] [Related]

  • 13. A flow cytometry-based assay for screening FimH antagonists.
    Scharenberg M, Abgottspon D, Cicek E, Jiang X, Schwardt O, Rabbani S, Ernst B.
    Assay Drug Dev Technol; 2011 Oct 26; 9(5):455-64. PubMed ID: 21675870
    [Abstract] [Full Text] [Related]

  • 14. Surface display of uropathogenic Escherichia coli FimH in Lactococcus lactis: In vitro characterization of recombinant bacteria and its protectivity in animal model.
    Derakhshandeh S, Shahrokhi N, Khalaj V, Habibi M, Moazzezy N, Asadi Karam MR, Bouzari S.
    Microb Pathog; 2020 Apr 26; 141():103974. PubMed ID: 31926238
    [Abstract] [Full Text] [Related]

  • 15. The Remarkable Biomechanical Properties of the Type 1 Chaperone-Usher Pilus: A Structural and Molecular Perspective.
    Hospenthal MK, Waksman G.
    Microbiol Spectr; 2019 Jan 26; 7(1):. PubMed ID: 30681068
    [Abstract] [Full Text] [Related]

  • 16. Plant phenolics inhibit focal adhesion kinase and suppress host cell invasion by uropathogenic Escherichia coli.
    Lewis AJ, Richards AC, Mendez AA, Dhakal BK, Jones TA, Sundsbak JL, Eto DS, Rousek AA, Mulvey MA.
    Infect Immun; 2024 May 07; 92(5):e0008024. PubMed ID: 38534100
    [Abstract] [Full Text] [Related]

  • 17. Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation.
    Schwartz DJ, Kalas V, Pinkner JS, Chen SL, Spaulding CN, Dodson KW, Hultgren SJ.
    Proc Natl Acad Sci U S A; 2013 Sep 24; 110(39):15530-7. PubMed ID: 24003161
    [Abstract] [Full Text] [Related]

  • 18. Antiadhesion therapy for urinary tract infections--a balanced PK/PD profile proved to be key for success.
    Jiang X, Abgottspon D, Kleeb S, Rabbani S, Scharenberg M, Wittwer M, Haug M, Schwardt O, Ernst B.
    J Med Chem; 2012 May 24; 55(10):4700-13. PubMed ID: 22519985
    [Abstract] [Full Text] [Related]

  • 19. Production of the Escherichia coli common pilus by uropathogenic E. coli is associated with adherence to HeLa and HTB-4 cells and invasion of mouse bladder urothelium.
    Saldaña Z, De la Cruz MA, Carrillo-Casas EM, Durán L, Zhang Y, Hernández-Castro R, Puente JL, Daaka Y, Girón JA.
    PLoS One; 2014 May 24; 9(7):e101200. PubMed ID: 25036370
    [Abstract] [Full Text] [Related]

  • 20. Distribution of chaperone-usher fimbriae and curli fimbriae among uropathogenic Escherichia coli.
    Golpasand T, Keshvari M, Behzadi P.
    BMC Microbiol; 2024 Sep 14; 24(1):344. PubMed ID: 39271999
    [Abstract] [Full Text] [Related]

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