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Journal Abstract Search

120 related items for PubMed ID: 28628208

  • 1. Carbocyclic C-C Bond Formation: Intramolecular Radical Ring Closure to Yield Diastereomerically Pure (7'S-Me- or 7'R-Me-) Carba-LNA Nucleotide Analogs.
    Plashkevych O, Upadhayaya RS, Chattopadhyaya J.
    Curr Protoc Nucleic Acid Chem; 2017 Jun 19; 69():4.74.1-4.74.42. PubMed ID: 28628208
    [Abstract] [Full Text] [Related]

  • 2. Free-radical ring closure to conformationally locked α-L-carba-LNAs and synthesis of their oligos: nuclease stability, target RNA specificity, and elicitation of RNase H.
    Li Q, Yuan F, Zhou C, Plashkevych O, Chattopadhyaya J.
    J Org Chem; 2010 Sep 17; 75(18):6122-40. PubMed ID: 20738147
    [Abstract] [Full Text] [Related]

  • 3. Carba-LNA-5MeC/A/G/T modified oligos show nucleobase-specific modulation of 3'-exonuclease activity, thermodynamic stability, RNA selectivity, and RNase H elicitation: synthesis and biochemistry.
    Upadhayaya R, Deshpande SG, Li Q, Kardile RA, Sayyed AY, Kshirsagar EK, Salunke RV, Dixit SS, Zhou C, Földesi A, Chattopadhyaya J.
    J Org Chem; 2011 Jun 03; 76(11):4408-31. PubMed ID: 21500818
    [Abstract] [Full Text] [Related]

  • 4. Double sugar and phosphate backbone-constrained nucleotides: synthesis, structure, stability, and their incorporation into oligodeoxynucleotides.
    Zhou C, Plashkevych O, Chattopadhyaya J.
    J Org Chem; 2009 May 01; 74(9):3248-65. PubMed ID: 19348480
    [Abstract] [Full Text] [Related]

  • 5. Synthesis of conformationally locked Carba-LNAs through intramolecular free-radical addition to C=N. Electrostatic and steric implication of the carba-LNA substituents in the modified oligos for nuclease and thermodynamic stabilities.
    Xu J, Liu Y, Dupouy C, Chattopadhyaya J.
    J Org Chem; 2009 Sep 04; 74(17):6534-54. PubMed ID: 19670835
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  • 8. How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?
    Plashkevych O, Li Q, Chattopadhyaya J.
    Mol Biosyst; 2017 May 02; 13(5):921-938. PubMed ID: 28352859
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  • 10. Molecular structure of the core-modified siRNA duplexes containing diastereomeric pair of [C6'(R)-OH]- versus [C6'(S)-OH]-carba-LNAs suggests a model for RNAi action.
    Plashkevych O, Chattopadhyaya J.
    Nucleosides Nucleotides Nucleic Acids; 2011 Nov 02; 30(11):815-25. PubMed ID: 22060548
    [Abstract] [Full Text] [Related]

  • 11. Steric effects in the tuning of the diastereoselectivity of the intramolecular free-radical cyclization to an olefin as exemplified through the synthesis of a carba-pentofuranose scaffold.
    Karimiahmadabadi M, Erfan S, Földesi A, Chattopadhyaya J.
    J Org Chem; 2012 Aug 17; 77(16):6855-72. PubMed ID: 22857001
    [Abstract] [Full Text] [Related]

  • 12. Intramolecular free-radical cyclization reactions on pentose sugars for the synthesis of carba-LNA and carba-ENA and the application of their modified oligonucleotides as potential RNA targeted therapeutics.
    Zhou C, Chattopadhyaya J.
    Chem Rev; 2012 Jul 11; 112(7):3808-32. PubMed ID: 22530946
    [No Abstract] [Full Text] [Related]

  • 13. Unusual radical 6-endo cyclization to carbocyclic-ENA and elucidation of its solution conformation by 600 MHz NMR and ab initio calculations.
    Zhou C, Plashkevych O, Chattopadhyaya J.
    Org Biomol Chem; 2008 Dec 21; 6(24):4627-33. PubMed ID: 19039373
    [Abstract] [Full Text] [Related]

  • 14. Structures, dynamics, and stabilities of fully modified locked nucleic acid (β-D-LNA and α-L-LNA) duplexes in comparison to pure DNA and RNA duplexes.
    Suresh G, Priyakumar UD.
    J Phys Chem B; 2013 May 09; 117(18):5556-64. PubMed ID: 23617391
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA, and 2'-Amino-LNA Monomers.
    Ries A, Kumar R, Lou C, Kosbar T, Vengut-Climent E, Jørgensen PT, Morales JC, Wengel J.
    J Org Chem; 2016 Nov 18; 81(22):10845-10856. PubMed ID: 27736097
    [Abstract] [Full Text] [Related]

  • 16. LNA (locked nucleic acid) and the diastereoisomeric alpha-L-LNA: conformational tuning and high-affinity recognition of DNA/RNA targets.
    Wengel J, Petersen M, Nielsen KE, Jensen GA, Håkansson AE, Kumar R, Sørensen MD, Rajwanshi VK, Bryld T, Jacobsen JP.
    Nucleosides Nucleotides Nucleic Acids; 2001 Nov 18; 20(4-7):389-96. PubMed ID: 11563053
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  • 17. Synthesis of 2',4'-propylene-bridged (carba-ENA) thymidine and its analogues: the engineering of electrostatic and steric effects at the bottom of the minor groove for nuclease and thermodynamic stabilities and elicitation of RNase H.
    Liu Y, Xu J, Karimiahmadabadi M, Zhou C, Chattopadhyaya J.
    J Org Chem; 2010 Nov 05; 75(21):7112-28. PubMed ID: 20929200
    [Abstract] [Full Text] [Related]

  • 18. The conformations of locked nucleic acids (LNA).
    Petersen M, Nielsen CB, Nielsen KE, Jensen GA, Bondensgaard K, Singh SK, Rajwanshi VK, Koshkin AA, Dahl BM, Wengel J, Jacobsen JP.
    J Mol Recognit; 2000 Nov 05; 13(1):44-53. PubMed ID: 10679896
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and biophysical evaluation of 3'-Me-α-L-LNA - Substitution in the minor groove of α-L-LNA duplexes.
    Seth PP, Allerson CA, Østergaard ME, Swayze EE.
    Bioorg Med Chem Lett; 2011 Aug 15; 21(16):4690-4. PubMed ID: 21778053
    [Abstract] [Full Text] [Related]

  • 20. Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids.
    Petersen M, Bondensgaard K, Wengel J, Jacobsen JP.
    J Am Chem Soc; 2002 May 29; 124(21):5974-82. PubMed ID: 12022830
    [Abstract] [Full Text] [Related]

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