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PUBMED FOR HANDHELDS

Journal Abstract Search

266 related items for PubMed ID: 28651982

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  • 3. New azoles with antifungal activity: Design, synthesis, and molecular docking.
    Chai X, Zhang J, Cao Y, Zou Y, Wu Q, Zhang D, Jiang Y, Sun Q.
    Bioorg Med Chem Lett; 2011 Jan 15; 21(2):686-9. PubMed ID: 21190856
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  • 4. Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.
    Hargrove TY, Garvey EP, Hoekstra WJ, Yates CM, Wawrzak Z, Rachakonda G, Villalta F, Lepesheva GI.
    Antimicrob Agents Chemother; 2017 Jul 15; 61(7):. PubMed ID: 28461309
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  • 6. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme.
    Warrilow AG, Hull CM, Parker JE, Garvey EP, Hoekstra WJ, Moore WR, Schotzinger RJ, Kelly DE, Kelly SL.
    Antimicrob Agents Chemother; 2014 Dec 15; 58(12):7121-7. PubMed ID: 25224009
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  • 8. Comparison and analysis of the structures and binding modes of antifungal SE and CYP51 inhibitors.
    Sun B, Huang W, Liu M, Lei K.
    J Mol Graph Model; 2017 Oct 15; 77():1-8. PubMed ID: 28802152
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  • 9. Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections.
    Zhu T, Chen X, Li C, Tu J, Liu N, Xu D, Sheng C.
    Eur J Med Chem; 2021 Oct 05; 221():113524. PubMed ID: 33992927
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  • 10. Fungal-specific Cyp51 inhibitor VT-1598 demonstrates in vitro activity against Candida and Cryptococcus species, endemic fungi, including Coccidioides species, Aspergillus species and Rhizopus arrhizus.
    Wiederhold NP, Patterson HP, Tran BH, Yates CM, Schotzinger RJ, Garvey EP.
    J Antimicrob Chemother; 2018 Feb 01; 73(2):404-408. PubMed ID: 29190379
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  • 11. Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals.
    Tyndall JD, Sabherwal M, Sagatova AA, Keniya MV, Negroni J, Wilson RK, Woods MA, Tietjen K, Monk BC.
    PLoS One; 2016 Feb 01; 11(12):e0167485. PubMed ID: 27907120
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  • 12. Tetrazole hybrids and their antifungal activities.
    Wang SQ, Wang YF, Xu Z.
    Eur J Med Chem; 2019 May 15; 170():225-234. PubMed ID: 30904780
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  • 14. Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.
    Sagatova AA, Keniya MV, Wilson RK, Monk BC, Tyndall JD.
    Antimicrob Agents Chemother; 2015 Aug 15; 59(8):4982-9. PubMed ID: 26055382
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  • 15. Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design.
    Monk BC, Sagatova AA, Hosseini P, Ruma YN, Wilson RK, Keniya MV.
    Biochim Biophys Acta Proteins Proteom; 2020 Mar 15; 1868(3):140206. PubMed ID: 30851431
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  • 16. Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis.
    Han G, Liu N, Li C, Tu J, Li Z, Sheng C.
    J Med Chem; 2020 May 28; 63(10):5341-5359. PubMed ID: 32347094
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  • 17. Modeling and interactions of Aspergillus fumigatus lanosterol 14-alpha demethylase 'A' with azole antifungals.
    Gollapudy R, Ajmani S, Kulkarni SA.
    Bioorg Med Chem; 2004 Jun 01; 12(11):2937-50. PubMed ID: 15142553
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  • 18. Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.
    Friggeri L, Hargrove TY, Wawrzak Z, Blobaum AL, Rachakonda G, Lindsley CW, Villalta F, Nes WD, Botta M, Guengerich FP, Lepesheva GI.
    J Med Chem; 2018 Jul 12; 61(13):5679-5691. PubMed ID: 29894182
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  • 19. The novel fungal CYP51 inhibitor VT-1598 displays classic dose-dependent antifungal activity in murine models of invasive aspergillosis.
    Garvey EP, Sharp AD, Warn PA, Yates CM, Atari M, Thomas S, Schotzinger RJ.
    Med Mycol; 2020 Jun 01; 58(4):505-513. PubMed ID: 32476008
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  • 20. Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase.
    Yu S, Chai X, Hu H, Yan Y, Guan Z, Zou Y, Sun Q, Wu Q.
    Eur J Med Chem; 2010 Oct 01; 45(10):4435-45. PubMed ID: 20675019
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