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Journal Abstract Search

154 related items for PubMed ID: 2867872

  • 21. Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.
    Singh R, Silva Elipe MV, Pearson PG, Arison BH, Wong BK, White R, Yu X, Burgey CS, Lin JH, Baillie TA.
    Chem Res Toxicol; 2003 Feb; 16(2):198-207. PubMed ID: 12588191
    [Abstract] [Full Text] [Related]

  • 22. Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells.
    Lanza DL, Code E, Crespi CL, Gonzalez FJ, Yost GS.
    Drug Metab Dispos; 1999 Jul; 27(7):798-803. PubMed ID: 10383923
    [Abstract] [Full Text] [Related]

  • 23. Decreased pneumotoxicity of deuterated 3-methylindole: bioactivation requires methyl C-H bond breakage.
    Huijzer JC, Adams JD, Yost GS.
    Toxicol Appl Pharmacol; 1987 Aug; 90(1):60-8. PubMed ID: 3629592
    [Abstract] [Full Text] [Related]

  • 24. Phase II in vitro metabolism of 3-methylindole metabolites in porcine liver.
    Diaz GJ, Squires EJ.
    Xenobiotica; 2003 May; 33(5):485-98. PubMed ID: 12746105
    [Abstract] [Full Text] [Related]

  • 25. Autoradiographic evidence of 3-methylindole covalent binding to pulmonary epithelial cells in the goat.
    Becker GM, Breeze RG, Carlson JR.
    Toxicology; 1984 May 14; 31(2):109-21. PubMed ID: 6204422
    [Abstract] [Full Text] [Related]

  • 26. In vitro covalent binding of 3-[14C]methylindole metabolites in goat tissues.
    Bray TM, Carlson JR, Nocerini MR.
    Proc Soc Exp Biol Med; 1984 May 14; 176(1):48-53. PubMed ID: 6709651
    [Abstract] [Full Text] [Related]

  • 27. Identification of goat and mouse urinary metabolites of the pneumotoxin, 3-methylindole.
    Smith DJ, Skiles GL, Appleton ML, Carlson JR, Yost GS.
    Xenobiotica; 1993 Sep 14; 23(9):1025-44. PubMed ID: 8291262
    [Abstract] [Full Text] [Related]

  • 28. One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.
    Boerma JS, Vermeulen NP, Commandeur JN.
    Chem Biol Interact; 2014 Jan 25; 207():32-40. PubMed ID: 24246759
    [Abstract] [Full Text] [Related]

  • 29. Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.
    Kassahun K, Skordos K, McIntosh I, Slaughter D, Doss GA, Baillie TA, Yost GS.
    Chem Res Toxicol; 2005 Sep 25; 18(9):1427-37. PubMed ID: 16167835
    [Abstract] [Full Text] [Related]

  • 30. Production and characterization of specific antibodies: utilization to predict organ- and species-selective pneumotoxicity of 3-methylindole.
    Kaster JK, Yost GS.
    Toxicol Appl Pharmacol; 1997 Apr 25; 143(2):324-37. PubMed ID: 9144449
    [Abstract] [Full Text] [Related]

  • 31. Identification of beta-glucuronidase-resistant diastereomeric glucuronides of 3-hydroxy-3-methyloxindole formed during 3-methylindole metabolism in goats.
    Smith DJ, Appleton ML, Carlson JR, Yost GS.
    Drug Metab Dispos; 1996 Jan 25; 24(1):119-25. PubMed ID: 8825199
    [Abstract] [Full Text] [Related]

  • 32. Role of mixed-function oxidase in 3-methylindole-induced acute pulmonary edema in goats.
    Bray TM, Carlson JR.
    Am J Vet Res; 1979 Sep 25; 40(9):1268-72. PubMed ID: 525930
    [Abstract] [Full Text] [Related]

  • 33. The effect of dietary and sulfur compounds in alleviating 3-methylindole-induced pulmonary toxicity in goats.
    Merrill JC, Bray TM.
    J Nutr; 1983 Sep 25; 113(9):1725-31. PubMed ID: 6886820
    [Abstract] [Full Text] [Related]

  • 34. Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4.
    Kalgutkar AS, Henne KR, Lame ME, Vaz AD, Collin C, Soglia JR, Zhao SX, Hop CE.
    Chem Biol Interact; 2005 Jun 30; 155(1-2):10-20. PubMed ID: 15978881
    [Abstract] [Full Text] [Related]

  • 35. Mechanism-based inactivation of lung-selective cytochrome P450 CYP2F enzymes.
    Kartha JS, Yost GS.
    Drug Metab Dispos; 2008 Jan 30; 36(1):155-62. PubMed ID: 17962375
    [Abstract] [Full Text] [Related]

  • 36. Concentration of 3-methylindole (3MI) and distribution of radioactivity from 14C-3MI in goat tissues associated with acute pulmonary edema.
    Bradley BJ, Carlson JR.
    Life Sci; 1982 Feb 01; 30(5):455-63. PubMed ID: 7062807
    [Abstract] [Full Text] [Related]

  • 37. Cloning and expression of CYP2F3, a cytochrome P450 that bioactivates the selective pneumotoxins 3-methylindole and naphthalene.
    Wang H, Lanza DL, Yost GS.
    Arch Biochem Biophys; 1998 Jan 15; 349(2):329-40. PubMed ID: 9448722
    [Abstract] [Full Text] [Related]

  • 38. Detection and characterization of DNA adducts of 3-methylindole.
    Regal KA, Laws GM, Yuan C, Yost GS, Skiles GL.
    Chem Res Toxicol; 2001 Aug 15; 14(8):1014-24. PubMed ID: 11511175
    [Abstract] [Full Text] [Related]

  • 39. Evidence supporting the formation of 2,3-epoxy-3-methylindoline: a reactive intermediate of the pneumotoxin 3-methylindole.
    Skordos KW, Skiles GL, Laycock JD, Lanza DL, Yost GS.
    Chem Res Toxicol; 1998 Jul 15; 11(7):741-9. PubMed ID: 9671536
    [Abstract] [Full Text] [Related]

  • 40. Metabolic activation of a novel 3-substituted indole-containing TNF-alpha inhibitor: dehydrogenation and inactivation of CYP3A4.
    Sun H, Yost GS.
    Chem Res Toxicol; 2008 Feb 15; 21(2):374-85. PubMed ID: 18095656
    [Abstract] [Full Text] [Related]

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