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Journal Abstract Search

170 related items for PubMed ID: 28692297

  • 1. Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane.
    Blank BR, Gut J, Rosenthal PJ, Renslo AR.
    J Med Chem; 2017 Jul 27; 60(14):6400-6407. PubMed ID: 28692297
    [Abstract] [Full Text] [Related]

  • 2. The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
    Dong Y, Wittlin S, Sriraghavan K, Chollet J, Charman SA, Charman WN, Scheurer C, Urwyler H, Santo Tomas J, Snyder C, Creek DJ, Morizzi J, Koltun M, Matile H, Wang X, Padmanilayam M, Tang Y, Dorn A, Brun R, Vennerstrom JL.
    J Med Chem; 2010 Jan 14; 53(1):481-91. PubMed ID: 19924861
    [Abstract] [Full Text] [Related]

  • 3. Drug delivery to the malaria parasite using an arterolane-like scaffold.
    Fontaine SD, Spangler B, Gut J, Lauterwasser EM, Rosenthal PJ, Renslo AR.
    ChemMedChem; 2015 Jan 14; 10(1):47-51. PubMed ID: 25314098
    [Abstract] [Full Text] [Related]

  • 4. Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
    Wang X, Dong Y, Wittlin S, Charman SA, Chiu FC, Chollet J, Katneni K, Mannila J, Morizzi J, Ryan E, Scheurer C, Steuten J, Santo Tomas J, Snyder C, Vennerstrom JL.
    J Med Chem; 2013 Mar 28; 56(6):2547-55. PubMed ID: 23489135
    [Abstract] [Full Text] [Related]

  • 5. Efficacy and safety of fixed dose combination of arterolane maleate and piperaquine phosphate dispersible tablets in paediatric patients with acute uncomplicated Plasmodium falciparum malaria: a phase II, multicentric, open-label study.
    Toure OA, Rulisa S, Anvikar AR, Rao BS, Mishra P, Jalali RK, Arora S, Roy A, Saha N, Iyer SS, Sharma P, Valecha N.
    Malar J; 2015 Nov 25; 14():469. PubMed ID: 26608469
    [Abstract] [Full Text] [Related]

  • 6. Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.
    Creek DJ, Charman WN, Chiu FC, Prankerd RJ, McCullough KJ, Dong Y, Vennerstrom JL, Charman SA.
    J Pharm Sci; 2007 Nov 25; 96(11):2945-56. PubMed ID: 17549767
    [Abstract] [Full Text] [Related]

  • 7. Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.
    Bousejra-El Garah F, Wong MH, Amewu RK, Muangnoicharoen S, Maggs JL, Stigliani JL, Park BK, Chadwick J, Ward SA, O'Neill PM.
    J Med Chem; 2011 Oct 13; 54(19):6443-55. PubMed ID: 21888440
    [Abstract] [Full Text] [Related]

  • 8. In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.
    Snyder C, Chollet J, Santo-Tomas J, Scheurer C, Wittlin S.
    Exp Parasitol; 2007 Mar 13; 115(3):296-300. PubMed ID: 17087929
    [Abstract] [Full Text] [Related]

  • 9. Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.
    Wang X, Dong Y, Wittlin S, Creek D, Chollet J, Charman SA, Tomas JS, Scheurer C, Snyder C, Vennerstrom JL.
    J Med Chem; 2007 Nov 15; 50(23):5840-7. PubMed ID: 17949067
    [Abstract] [Full Text] [Related]

  • 10. Antimalarial activity of 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) and its carboxylic acid derivatives.
    Sato A, Kawai S, Hiramoto A, Morita M, Tanigawa N, Nakase Y, Komichi Y, Matsumoto M, Hiraoka O, Hiramoto K, Tokuhara H, Masuyama A, Nojima M, Higaki K, Hayatsu H, Wataya Y, Kim HS.
    Parasitol Int; 2011 Dec 15; 60(4):488-92. PubMed ID: 21924377
    [Abstract] [Full Text] [Related]

  • 11. Arterolane, a new synthetic trioxolane for treatment of uncomplicated Plasmodium falciparum malaria: a phase II, multicenter, randomized, dose-finding clinical trial.
    Valecha N, Looareesuwan S, Martensson A, Abdulla SM, Krudsood S, Tangpukdee N, Mohanty S, Mishra SK, Tyagi PK, Sharma SK, Moehrle J, Gautam A, Roy A, Paliwal JK, Kothari M, Saha N, Dash AP, Björkman A.
    Clin Infect Dis; 2010 Sep 15; 51(6):684-91. PubMed ID: 20687837
    [Abstract] [Full Text] [Related]

  • 12.
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  • 14. Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals.
    Fügi MA, Wittlin S, Dong Y, Vennerstrom JL.
    Antimicrob Agents Chemother; 2010 Mar 15; 54(3):1042-6. PubMed ID: 20028825
    [Abstract] [Full Text] [Related]

  • 15. Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
    Vennerstrom JL, Fu HN, Ellis WY, Ager AL, Wood JK, Andersen SL, Gerena L, Milhous WK.
    J Med Chem; 1992 Aug 07; 35(16):3023-7. PubMed ID: 1501229
    [Abstract] [Full Text] [Related]

  • 16. Identification of an antimalarial synthetic trioxolane drug development candidate.
    Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FC, Chollet J, Dong Y, Dorn A, Hunziker D, Matile H, McIntosh K, Padmanilayam M, Santo Tomas J, Scheurer C, Scorneaux B, Tang Y, Urwyler H, Wittlin S, Charman WN.
    Nature; 2004 Aug 19; 430(7002):900-4. PubMed ID: 15318224
    [Abstract] [Full Text] [Related]

  • 17. Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
    Dong Y, Chollet J, Matile H, Charman SA, Chiu FC, Charman WN, Scorneaux B, Urwyler H, Santo Tomas J, Scheurer C, Snyder C, Dorn A, Wang X, Karle JM, Tang Y, Wittlin S, Brun R, Vennerstrom JL.
    J Med Chem; 2005 Jul 28; 48(15):4953-61. PubMed ID: 16033274
    [Abstract] [Full Text] [Related]

  • 18. Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).
    Uhlemann AC, Wittlin S, Matile H, Bustamante LY, Krishna S.
    Antimicrob Agents Chemother; 2007 Feb 28; 51(2):667-72. PubMed ID: 17145800
    [Abstract] [Full Text] [Related]

  • 19. Infectious diseases. Source of new hope against malaria is in short supply.
    Enserink M.
    Science; 2005 Jan 07; 307(5706):33. PubMed ID: 15637249
    [No Abstract] [Full Text] [Related]

  • 20. [Artemisinin and successors].
    Holzgrabe U.
    Pharm Unserer Zeit; 2005 Jan 07; 34(2):95. PubMed ID: 15803790
    [No Abstract] [Full Text] [Related]

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