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Journal Abstract Search

167 related items for PubMed ID: 28698302

  • 1. Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds.
    Lin HL, Zhang H, Walker VJ, D'Agostino J, Hollenberg PF.
    Drug Metab Dispos; 2017 Sep; 45(9):990-999. PubMed ID: 28698302
    [Abstract] [Full Text] [Related]

  • 2. Formation of Both Heme and Apoprotein Adducts Contributes to the Mechanism-Based Inactivation of Human CYP2J2 by 17α-Ethynylestradiol.
    Lin HL, Zhang H, Hollenberg PF.
    Drug Metab Dispos; 2018 Jun; 46(6):813-822. PubMed ID: 29602797
    [Abstract] [Full Text] [Related]

  • 3. The inactivation of cytochrome P450 3A5 by 17alpha-ethynylestradiol is cytochrome b5-dependent: metabolic activation of the ethynyl moiety leads to the formation of glutathione conjugates, a heme adduct, and covalent binding to the apoprotein.
    Lin HL, Hollenberg PF.
    J Pharmacol Exp Ther; 2007 Apr; 321(1):276-87. PubMed ID: 17251390
    [Abstract] [Full Text] [Related]

  • 4. Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486).
    He K, Woolf TF, Hollenberg PF.
    J Pharmacol Exp Ther; 1999 Feb; 288(2):791-7. PubMed ID: 9918590
    [Abstract] [Full Text] [Related]

  • 5. Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein.
    Lin HL, Zhang H, Noon KR, Hollenberg PF.
    J Pharmacol Exp Ther; 2009 Nov; 331(2):392-403. PubMed ID: 19700628
    [Abstract] [Full Text] [Related]

  • 6. Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites.
    Karkhanis A, Lam HY, Venkatesan G, Koh SK, Chai CL, Zhou L, Hong Y, Kojodjojo P, Chan EC.
    Biochem Pharmacol; 2016 May 01; 107():67-80. PubMed ID: 26972388
    [Abstract] [Full Text] [Related]

  • 7. Danazol Inhibits Cytochrome P450 2J2 Activity in a Substrate-independent Manner.
    Lee E, Wu Z, Shon JC, Liu KH.
    Drug Metab Dispos; 2015 Aug 01; 43(8):1250-3. PubMed ID: 26048912
    [Abstract] [Full Text] [Related]

  • 8. Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein.
    Lin HL, Kent UM, Hollenberg PF.
    J Pharmacol Exp Ther; 2002 Apr 01; 301(1):160-7. PubMed ID: 11907170
    [Abstract] [Full Text] [Related]

  • 9. Cytochrome P450BM-3 (CYP102): regiospecificity of oxidation of omega-unsaturated fatty acids and mechanism-based inactivation.
    Shirane N, Sui Z, Peterson JA, Ortiz de Montellano PR.
    Biochemistry; 1993 Dec 14; 32(49):13732-41. PubMed ID: 8257708
    [Abstract] [Full Text] [Related]

  • 10. Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine.
    Ikemura N, Yamaori S, Kobayashi C, Kamijo S, Murayama N, Yamazaki H, Ohmori S.
    Chem Biol Interact; 2019 Jun 01; 306():1-9. PubMed ID: 30965050
    [Abstract] [Full Text] [Related]

  • 11. The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation.
    Park SH, Lee J, Shon JC, Phuc NM, Jee JG, Liu KH.
    Phytomedicine; 2018 Mar 15; 42():199-206. PubMed ID: 29655687
    [Abstract] [Full Text] [Related]

  • 12. The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5.
    Lin HL, Kent UM, Hollenberg PF.
    J Pharmacol Exp Ther; 2005 Apr 15; 313(1):154-64. PubMed ID: 15608076
    [Abstract] [Full Text] [Related]

  • 13. Identification of novel substrates for human cytochrome P450 2J2.
    Lee CA, Neul D, Clouser-Roche A, Dalvie D, Wester MR, Jiang Y, Jones JP, Freiwald S, Zientek M, Totah RA.
    Drug Metab Dispos; 2010 Feb 15; 38(2):347-56. PubMed ID: 19923256
    [Abstract] [Full Text] [Related]

  • 14. Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: characterization of reactive intermediate adducts to the heme and apoprotein.
    Blobaum AL, Kent UM, Alworth WL, Hollenberg PF.
    Chem Res Toxicol; 2002 Dec 15; 15(12):1561-71. PubMed ID: 12482238
    [Abstract] [Full Text] [Related]

  • 15. Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2.
    Xu MJ, Jiang LF, Wu T, Chu JH, Wei YD, Aa JY, Wang GJ, Hao HP, Ju WZ, Li P.
    Chem Biol Interact; 2018 Jun 01; 289():15-22. PubMed ID: 29689254
    [Abstract] [Full Text] [Related]

  • 16. The development of novel cytochrome P450 2J2 (CYP2J2) inhibitor and the underlying interaction between inhibitor and CYP2J2.
    Tian X, Zhou M, Ning J, Deng X, Feng L, Huang H, Yao D, Ma X.
    J Enzyme Inhib Med Chem; 2021 Dec 01; 36(1):737-748. PubMed ID: 33682565
    [Abstract] [Full Text] [Related]

  • 17. Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme.
    Lu J, Liu D, Zhou X, Chen A, Jiang Z, Ye X, Liu M, Wang X.
    Phytomedicine; 2018 Jan 15; 39():137-145. PubMed ID: 29433675
    [Abstract] [Full Text] [Related]

  • 18. Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6.
    Kent UM, Lin HL, Mills DE, Regal KA, Hollenberg PF.
    Chem Res Toxicol; 2006 Feb 15; 19(2):279-87. PubMed ID: 16485904
    [Abstract] [Full Text] [Related]

  • 19. Identification of the heme adduct and an active site peptide modified during mechanism-based inactivation of rat liver cytochrome P450 2B1 by secobarbital.
    He K, Falick AM, Chen B, Nilsson F, Correia MA.
    Chem Res Toxicol; 1996 Feb 15; 9(3):614-22. PubMed ID: 8728507
    [Abstract] [Full Text] [Related]

  • 20. LKY-047: First Selective Inhibitor of Cytochrome P450 2J2.
    Phuc NM, Wu Z, O Y, Lee JH, Oh S, Song GY, Liu KH.
    Drug Metab Dispos; 2017 Jul 15; 45(7):765-769. PubMed ID: 28461575
    [Abstract] [Full Text] [Related]

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