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277 related items for PubMed ID: 28768413

  • 1. Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme.
    Shisler KA, Hutcheson RU, Horitani M, Duschene KS, Crain AV, Byer AS, Shepard EM, Rasmussen A, Yang J, Broderick WE, Vey JL, Drennan CL, Hoffman BM, Broderick JB.
    J Am Chem Soc; 2017 Aug 30; 139(34):11803-11813. PubMed ID: 28768413
    [Abstract] [Full Text] [Related]

  • 2. Electron-nuclear double resonance spectroscopic evidence that S-adenosylmethionine binds in contact with the catalytically active [4Fe-4S](+) cluster of pyruvate formate-lyase activating enzyme.
    Walsby CJ, Hong W, Broderick WE, Cheek J, Ortillo D, Broderick JB, Hoffman BM.
    J Am Chem Soc; 2002 Mar 27; 124(12):3143-51. PubMed ID: 11902903
    [Abstract] [Full Text] [Related]

  • 3. Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage.
    Moody JD, Hill S, Lundahl MN, Saxton AJ, Galambas A, Broderick WE, Lawrence CM, Broderick JB.
    J Biol Chem; 2023 Jun 27; 299(6):104791. PubMed ID: 37156396
    [Abstract] [Full Text] [Related]

  • 4. Pyruvate formate-lyase and its activation by pyruvate formate-lyase activating enzyme.
    Crain AV, Broderick JB.
    J Biol Chem; 2014 Feb 28; 289(9):5723-9. PubMed ID: 24338017
    [Abstract] [Full Text] [Related]

  • 5. An anchoring role for FeS clusters: chelation of the amino acid moiety of S-adenosylmethionine to the unique iron site of the [4Fe-4S] cluster of pyruvate formate-lyase activating enzyme.
    Walsby CJ, Ortillo D, Broderick WE, Broderick JB, Hoffman BM.
    J Am Chem Soc; 2002 Sep 25; 124(38):11270-1. PubMed ID: 12236732
    [Abstract] [Full Text] [Related]

  • 6. Mechanism of Radical Initiation in the Radical S-Adenosyl-l-methionine Superfamily.
    Broderick WE, Hoffman BM, Broderick JB.
    Acc Chem Res; 2018 Nov 20; 51(11):2611-2619. PubMed ID: 30346729
    [Abstract] [Full Text] [Related]

  • 7. Coordination of adenosylmethionine to a unique iron site of the [4Fe-4S] of pyruvate formate-lyase activating enzyme: a Mössbauer spectroscopic study.
    Krebs C, Broderick WE, Henshaw TF, Broderick JB, Huynh BH.
    J Am Chem Soc; 2002 Feb 13; 124(6):912-3. PubMed ID: 11829592
    [Abstract] [Full Text] [Related]

  • 8. ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S]2+ Cluster.
    Yang H, Ho MB, Lundahl MN, Mosquera MA, Broderick WE, Broderick JB, Hoffman BM.
    J Am Chem Soc; 2024 Feb 14; 146(6):3710-3720. PubMed ID: 38308759
    [Abstract] [Full Text] [Related]

  • 9. Pyruvate formate-lyase activating enzyme: The catalytically active 5'-deoxyadenosyl radical caught in the act of H-atom abstraction.
    Lundahl MN, Yang H, Broderick WE, Hoffman BM, Broderick JB.
    Proc Natl Acad Sci U S A; 2023 Nov 21; 120(47):e2314696120. PubMed ID: 37956301
    [Abstract] [Full Text] [Related]

  • 10. The iron-sulfur cluster of pyruvate formate-lyase activating enzyme in whole cells: cluster interconversion and a valence-localized [4Fe-4S]2+ state.
    Yang J, Naik SG, Ortillo DO, García-Serres R, Li M, Broderick WE, Huynh BH, Broderick JB.
    Biochemistry; 2009 Oct 06; 48(39):9234-41. PubMed ID: 19711960
    [Abstract] [Full Text] [Related]

  • 11.
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  • 12. Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis.
    Byer AS, Yang H, McDaniel EC, Kathiresan V, Impano S, Pagnier A, Watts H, Denler C, Vagstad AL, Piel J, Duschene KS, Shepard EM, Shields TP, Scott LG, Lilla EA, Yokoyama K, Broderick WE, Hoffman BM, Broderick JB.
    J Am Chem Soc; 2018 Jul 18; 140(28):8634-8638. PubMed ID: 29954180
    [Abstract] [Full Text] [Related]

  • 13. Pyruvate formate-lyase activating enzyme: elucidation of a novel mechanism for glycyl radical formation.
    Buis JM, Broderick JB.
    Arch Biochem Biophys; 2005 Jan 01; 433(1):288-96. PubMed ID: 15581584
    [Abstract] [Full Text] [Related]

  • 14. Pyruvate formate-lyase-activating enzyme: strictly anaerobic isolation yields active enzyme containing a [3Fe-4S](+) cluster.
    Broderick JB, Henshaw TF, Cheek J, Wojtuszewski K, Smith SR, Trojan MR, McGhan RM, Kopf A, Kibbey M, Broderick WE.
    Biochem Biophys Res Commun; 2000 Mar 16; 269(2):451-6. PubMed ID: 10708574
    [Abstract] [Full Text] [Related]

  • 15. Mechanistic Studies of Radical SAM Enzymes: Pyruvate Formate-Lyase Activating Enzyme and Lysine 2,3-Aminomutase Case Studies.
    Byer AS, McDaniel EC, Impano S, Broderick WE, Broderick JB.
    Methods Enzymol; 2018 Mar 16; 606():269-318. PubMed ID: 30097096
    [Abstract] [Full Text] [Related]

  • 16. Molecular properties of pyruvate formate-lyase activating enzyme.
    Wong KK, Murray BW, Lewisch SA, Baxter MK, Ridky TW, Ulissi-DeMario L, Kozarich JW.
    Biochemistry; 1993 Dec 28; 32(51):14102-10. PubMed ID: 8260492
    [Abstract] [Full Text] [Related]

  • 17. A dehydroalanyl residue can capture the 5'-deoxyadenosyl radical generated from S-adenosylmethionine by pyruvate formate-lyase-activating enzyme.
    Wagner AF, Demand J, Schilling G, Pils T, Knappe J.
    Biochem Biophys Res Commun; 1999 Jan 19; 254(2):306-10. PubMed ID: 9918833
    [Abstract] [Full Text] [Related]

  • 18. Glycyl radical activating enzymes: structure, mechanism, and substrate interactions.
    Shisler KA, Broderick JB.
    Arch Biochem Biophys; 2014 Mar 15; 546():64-71. PubMed ID: 24486374
    [Abstract] [Full Text] [Related]

  • 19. Pyruvate formate-lyase, evidence for an open conformation favored in the presence of its activating enzyme.
    Peng Y, Veneziano SE, Gillispie GD, Broderick JB.
    J Biol Chem; 2010 Aug 27; 285(35):27224-27231. PubMed ID: 20571026
    [Abstract] [Full Text] [Related]

  • 20. Reconstitution and characterization of the polynuclear iron-sulfur cluster in pyruvate formate-lyase-activating enzyme. Molecular properties of the holoenzyme form.
    Külzer R, Pils T, Kappl R, Hüttermann J, Knappe J.
    J Biol Chem; 1998 Feb 27; 273(9):4897-903. PubMed ID: 9478932
    [Abstract] [Full Text] [Related]

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