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329 related items for PubMed ID: 2881756

  • 1. Microsomal metabolism of pyrrolizidine alkaloids from Senecio jacobaea. Isolation and quantification of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine and N-oxides by high performance liquid chromatography.
    Ramsdell HS, Kedzierski B, Buhler DR.
    Drug Metab Dispos; 1987; 15(1):32-6. PubMed ID: 2881756
    [Abstract] [Full Text] [Related]

  • 2. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.
    Wang YP, Yan J, Fu PP, Chou MW.
    Toxicol Lett; 2005 Mar 15; 155(3):411-20. PubMed ID: 15649625
    [Abstract] [Full Text] [Related]

  • 3. Two dihydropyrrolizine alkaloid metabolites isolated from mouse hepatic microsomes in vitro.
    Segall HJ, Dallas JL, Haddon WF.
    Drug Metab Dispos; 1984 Mar 15; 12(1):68-71. PubMed ID: 6141915
    [Abstract] [Full Text] [Related]

  • 4. Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine.
    Xia Q, Yan J, Chou MW, Fu PP.
    Toxicol Lett; 2008 May 05; 178(2):77-82. PubMed ID: 18395999
    [Abstract] [Full Text] [Related]

  • 5. Metabolic activation of retronecine and retronecine N-oxide - formation of DHP-derived DNA adducts.
    Yan J, Xia Q, Chou MW, Fu PP.
    Toxicol Ind Health; 2008 Apr 05; 24(3):181-8. PubMed ID: 18842697
    [Abstract] [Full Text] [Related]

  • 6. The formation of 6,7-dihydro-7-hydroxy-1-hydroxy-methyl-5H-pyrrolizine, a metabolite of pyrrolizidine alkaloids.
    Kedzierski B, Buhler DR.
    Chem Biol Interact; 1986 Feb 05; 57(2):217-22. PubMed ID: 3955792
    [Abstract] [Full Text] [Related]

  • 7. Method for determination of pyrrolizidine alkaloids and their metabolites by high-performance liquid chromatography.
    Kedzierski B, Buhler DR.
    Anal Biochem; 1986 Jan 05; 152(1):59-65. PubMed ID: 3954045
    [Abstract] [Full Text] [Related]

  • 8. A new pyrrolizidine alkaloid metabolite, 19-hydroxysenecionine isolated from mouse hepatic microsomes in vitro.
    Eastman DF, Segall HJ.
    Drug Metab Dispos; 1982 Jan 05; 10(6):696-9. PubMed ID: 6130926
    [Abstract] [Full Text] [Related]

  • 9. Metabolism of [14C]monocrotaline by isolated perfused rat liver.
    Lamé MW, Jones AD, Morin D, Segall HJ.
    Drug Metab Dispos; 1991 Jan 05; 19(2):516-24. PubMed ID: 1676664
    [Abstract] [Full Text] [Related]

  • 10. Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver.
    Williams DE, Reed RL, Kedzierski B, Dannan GA, Guengerich FP, Buhler DR.
    Drug Metab Dispos; 1989 Jan 05; 17(4):387-92. PubMed ID: 2571477
    [Abstract] [Full Text] [Related]

  • 11. The effect of spironolactone treatment on the cytochrome P450-mediated metabolism of the pyrrolizidine alkaloid senecionine by hepatic microsomes from rats and guinea pigs.
    Chung WG, Buhler DR.
    Toxicol Appl Pharmacol; 1994 Aug 05; 127(2):314-9. PubMed ID: 8048076
    [Abstract] [Full Text] [Related]

  • 12. Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine.
    Xia Q, Chou MW, Edgar JA, Doerge DR, Fu PP.
    Cancer Lett; 2006 Jan 08; 231(1):138-45. PubMed ID: 16356839
    [Abstract] [Full Text] [Related]

  • 13. Determination of pyrrolizidine alkaloid metabolites from mouse liver microsomes using tandem mass spectrometry and gas chromatography/mass spectrometry.
    Winter CK, Segall HJ, Jones AD.
    Biomed Environ Mass Spectrom; 1988 Mar 01; 15(5):265-73. PubMed ID: 3365497
    [Abstract] [Full Text] [Related]

  • 14. 9-Glutathionyl-6,7-dihydro-1-hydroxymethyl-5H-pyrrolizine Is the Major Pyrrolic Glutathione Conjugate of Retronecine-Type Pyrrolizidine Alkaloids in Liver Microsomes and in Rats.
    Chen M, Li L, Zhong D, Shen S, Zheng J, Chen X.
    Chem Res Toxicol; 2016 Feb 15; 29(2):180-9. PubMed ID: 26761523
    [Abstract] [Full Text] [Related]

  • 15. N-acetylcysteine-conjugated pyrrole identified in rat urine following administration of two pyrrolizidine alkaloids, monocrotaline and senecionine.
    Estep JE, Lamé MW, Jones AD, Segall HJ.
    Toxicol Lett; 1990 Nov 15; 54(1):61-9. PubMed ID: 2123045
    [Abstract] [Full Text] [Related]

  • 16. Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo.
    Wang YP, Yan J, Beger RD, Fu PP, Chou MW.
    Cancer Lett; 2005 Aug 08; 226(1):27-35. PubMed ID: 16004930
    [Abstract] [Full Text] [Related]

  • 17. High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of pyrrolizidine alkaloid-derived DNA adducts in vitro and in vivo.
    Fu PP, Chou MW, Churchwell M, Wang Y, Zhao Y, Xia Q, Gamboa da Costa G, Marques MM, Beland FA, Doerge DR.
    Chem Res Toxicol; 2010 Mar 15; 23(3):637-52. PubMed ID: 20078085
    [Abstract] [Full Text] [Related]

  • 18. Evaporative light scattering detection of pyrrolizidine alkaloids.
    Schaneberg BT, Molyneux RJ, Khan IA.
    Phytochem Anal; 2004 Mar 15; 15(1):36-9. PubMed ID: 14979525
    [Abstract] [Full Text] [Related]

  • 19. Dietary selenium status and pyrrolizidine alkaloid metabolism in vitro by rat liver microsomes.
    Shull LR, Buckmaster GW, Cheeke PR.
    Res Commun Chem Pathol Pharmacol; 1977 Jun 15; 17(2):337-40. PubMed ID: 877417
    [Abstract] [Full Text] [Related]

  • 20. Quantitative analysis of total retronecine esters-type pyrrolizidine alkaloids in plant by high performance liquid chromatography.
    Zhang F, Wang CH, Xiong AZ, Wang W, Yang L, Branford-White CJ, Wang ZT, Bligh SW.
    Anal Chim Acta; 2007 Dec 12; 605(1):94-101. PubMed ID: 18022416
    [Abstract] [Full Text] [Related]

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