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162 related items for PubMed ID: 28832499

  • 1. A Molecular Modeling Study of the Hydroxyflutamide Resistance Mechanism Induced by Androgen Receptor Mutations.
    Liu HL, Zhong HY, Song TQ, Li JZ.
    Int J Mol Sci; 2017 Aug 23; 18(9):. PubMed ID: 28832499
    [Abstract] [Full Text] [Related]

  • 2. Study of the impact of the T877A mutation on ligand-induced helix-12 positioning of the androgen receptor resulted in design and synthesis of novel antiandrogens.
    Zhou J, Liu B, Geng G, Wu JH.
    Proteins; 2010 Feb 15; 78(3):623-37. PubMed ID: 19787772
    [Abstract] [Full Text] [Related]

  • 3. Molecular mechanism of R-bicalutamide switching from androgen receptor antagonist to agonist induced by amino acid mutations using molecular dynamics simulations and free energy calculation.
    Liu H, Han R, Li J, Liu H, Zheng L.
    J Comput Aided Mol Des; 2016 Dec 15; 30(12):1189-1200. PubMed ID: 27848066
    [Abstract] [Full Text] [Related]

  • 4. Molecular Dynamics Studies on the Enzalutamide Resistance Mechanisms Induced by Androgen Receptor Mutations.
    Liu H, Wang L, Tian J, Li J, Liu H.
    J Cell Biochem; 2017 Sep 15; 118(9):2792-2801. PubMed ID: 28181296
    [Abstract] [Full Text] [Related]

  • 5. The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay.
    Ozers MS, Marks BD, Gowda K, Kupcho KR, Ervin KM, De Rosier T, Qadir N, Eliason HC, Riddle SM, Shekhani MS.
    Biochemistry; 2007 Jan 23; 46(3):683-95. PubMed ID: 17223690
    [Abstract] [Full Text] [Related]

  • 6. Interaction mechanism exploration of R-bicalutamide/S-1 with WT/W741L AR using molecular dynamics simulations.
    Liu H, An X, Li S, Wang Y, Li J, Liu H.
    Mol Biosyst; 2015 Dec 23; 11(12):3347-54. PubMed ID: 26442831
    [Abstract] [Full Text] [Related]

  • 7. Molecular Dynamics Simulations Revealed the Regulation of Ligands to the Interactions between Androgen Receptor and Its Coactivator.
    Liu N, Zhou W, Guo Y, Wang J, Fu W, Sun H, Li D, Duan M, Hou T.
    J Chem Inf Model; 2018 Aug 27; 58(8):1652-1661. PubMed ID: 29993249
    [Abstract] [Full Text] [Related]

  • 8. Effects of steroidal and non-steroidal antiandrogens on wild-type and mutant androgen receptors.
    Urushibara M, Ishioka J, Hyochi N, Kihara K, Hara S, Singh P, Isaacs JT, Kageyama Y.
    Prostate; 2007 Jun 01; 67(8):799-807. PubMed ID: 17373727
    [Abstract] [Full Text] [Related]

  • 9. A novel steroidal antiandrogen targeting wild type and mutant androgen receptors.
    Andrieu T, Bertolini R, Nichols SE, Setoud R, Frey FJ, Baker ME, Frey BM.
    Biochem Pharmacol; 2011 Dec 01; 82(11):1651-62. PubMed ID: 21907706
    [Abstract] [Full Text] [Related]

  • 10. Antiandrogens prevent stable DNA-binding of the androgen receptor.
    Farla P, Hersmus R, Trapman J, Houtsmuller AB.
    J Cell Sci; 2005 Sep 15; 118(Pt 18):4187-98. PubMed ID: 16141232
    [Abstract] [Full Text] [Related]

  • 11. Suppression of mutant androgen receptors by flutamide.
    Ishioka J, Hara S, Isaacs JT, Tomura A, Nishikawa K, Kageyama Y.
    Int J Urol; 2009 May 15; 16(5):516-21. PubMed ID: 19389135
    [Abstract] [Full Text] [Related]

  • 12. Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells.
    Tan J, Sharief Y, Hamil KG, Gregory CW, Zang DY, Sar M, Gumerlock PH, deVere White RW, Pretlow TG, Harris SE, Wilson EM, Mohler JL, French FS.
    Mol Endocrinol; 1997 Apr 15; 11(4):450-9. PubMed ID: 9092797
    [Abstract] [Full Text] [Related]

  • 13. Learning from estrogen receptor antagonism: structure-based identification of novel antiandrogens effective against multiple clinically relevant androgen receptor mutants.
    Liu B, Geng G, Lin R, Ren C, Wu JH.
    Chem Biol Drug Des; 2012 Mar 15; 79(3):300-12. PubMed ID: 22151347
    [Abstract] [Full Text] [Related]

  • 14. Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function.
    Buchanan G, Yang M, Harris JM, Nahm HS, Han G, Moore N, Bentel JM, Matusik RJ, Horsfall DJ, Marshall VR, Greenberg NM, Tilley WD.
    Mol Endocrinol; 2001 Jan 15; 15(1):46-56. PubMed ID: 11145738
    [Abstract] [Full Text] [Related]

  • 15. Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.
    Lee YF, Lin WJ, Huang J, Messing EM, Chan FL, Wilding G, Chang C.
    Cancer Res; 2002 Nov 01; 62(21):6039-44. PubMed ID: 12414626
    [Abstract] [Full Text] [Related]

  • 16. Impaired helix 12 dynamics due to proline 892 substitutions in the androgen receptor are associated with complete androgen insensitivity.
    Elhaji YA, Stoica I, Dennis S, Purisima EO, Lumbroso R, Beitel LK, Trifiro MA.
    Hum Mol Genet; 2006 Mar 15; 15(6):921-31. PubMed ID: 16449235
    [Abstract] [Full Text] [Related]

  • 17. Communication between the Ligand-Binding Pocket and the Activation Function-2 Domain of Androgen Receptor Revealed by Molecular Dynamics Simulations.
    Jin Y, Duan M, Wang X, Kong X, Zhou W, Sun H, Liu H, Li D, Yu H, Li Y, Hou T.
    J Chem Inf Model; 2019 Feb 25; 59(2):842-857. PubMed ID: 30658039
    [Abstract] [Full Text] [Related]

  • 18. New Insights into the Binding Mechanism of Co-regulator BUD31 to AR AF2 Site: Structural Determination and Analysis of the Mutation Effect.
    Song T, Li J.
    Curr Comput Aided Drug Des; 2020 Feb 25; 16(1):45-53. PubMed ID: 31057123
    [Abstract] [Full Text] [Related]

  • 19. Isolation and characterization of the androgen receptor mutants with divergent transcriptional activity in response to hydroxyflutamide.
    Wang C, Young WJ, Chang C.
    Endocrine; 2000 Feb 25; 12(1):69-76. PubMed ID: 10855693
    [Abstract] [Full Text] [Related]

  • 20. Antiandrogens act as selective androgen receptor modulators at the proteome level in prostate cancer cells.
    Brooke GN, Gamble SC, Hough MA, Begum S, Dart DA, Odontiadis M, Powell SM, Fioretti FM, Bryan RA, Waxman J, Wait R, Bevan CL.
    Mol Cell Proteomics; 2015 May 25; 14(5):1201-16. PubMed ID: 25693800
    [Abstract] [Full Text] [Related]

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